2 Matching Annotations
  1. Jan 2020
    1. RESULTS: In the hypothyroid state, the plasma volume measured by dilution of 125I-albumin (APV) was higher than the calculated plasma volume (CPV) from packed red cell mass, suggesting an extravascular escape of albumin. After substitutive therapy, the CPV showed a statistical increase (P < 0.05), whereas APV remained unchanged. Both ERPF and GFR increased after thyroxine therapy (p < 0.05). In the subclinical group, blood volumes and renal function were similar to those found in the other group of patients when in the euthyroid state.

      If this holds true, I'd expect rapid blood volume expansion from thyroid hormone. I'm also interested in whether thyroid hormone stimulates the production of albumin, given its anabolic properties.

  2. Jan 2019
    1. Given parenterally in dosages sufficient to produce clear-cut increases in the metabolic balances, neither norethandrolone nor nandrolone produced any significant effects on independently measured synthesis or degradation of albumin.

      That is rather unfortunate. It appears rather dificult to have in impact on albumin metabolism.