fresh perspective

• cancer can be interpreted as a breakdown in the bodies multiscale competency architecture causing cancerous cells to lose their higher level synchronizing signals and revert to their more evolutionarily primitive forms as individuals that see the body as simply an external environment

adjacency between

• gap junction coupling
• cancer
• healthy tissue coherence
• multiscale competency architecture

• gap junction coupling appears to be an evolutionary means of cohering individuals together to form a larger group
• hence, they seem to play a critical role in the continued evolution of more complex multicellular organisms
• their pathologies within multicellular beings destroy multicellular structures and create disease, reverting the organism, or competent multicellular structures of the organism such as tissues and organs back to individualistic behavior, as in cancers

paraphrase

• The multiscale competency architecture of life is a hypothesis about the scaling of cognition, seeing complex system-level behaviors in any space as the
  • within-level and
  • across-level
• competition and
• cooperation
• among the various
  • subunits and
  • partitions
• of composite agents (i.e., all agents).
• The generalization of problem spaces beyond the traditional 3D space of “behavior” into other, virtual problem spaces is essential for understanding evolution of basal cognition.
• Living things
  • first solved problems in metabolic space, and evolution then pivoted the same kinds of strategies to
  • solve problems in
    • physiological,
    • transcriptional, and
    • anatomical space,
  • before speed-optimizing these dynamics to enable rapid behavior in 3D space.
• Since every cognitive agent is made of parts, it is essential to have a theory about how
  • numerous goal-seeking agents link together into
  • a new, larger cognitive system that is novel and not present in any of the subunits.

comment

• multiscale competency architecture
• superorganism

adjacency statement

• The concept of multiscale competency architecture is a useful one for considering and organizing the effects of Major Evolutionary Transitions (METs) over evolutionary timescales.
• It links and locates the normative scale in which human consciousness exists to the lower scales of cells and subcellular life below, and to society as a social superorganism above.
• it shows that each human INTERbeing / INTERbeCOMing is not isolated, but is part of a multiscale nexus / gestalt
• I've incorporated this into my SRG presentation.

question

• is there research on signaling mechanisms exist between different levels?
  • in another part of the paper, there is discussion of gap junctions as a way to cohere individual cells into group functionality
  • in particular, is there a way for humans consciousness to communicate with lower levels of its body? ie. to tissues, cells or subcellular structures?
• Could the Bodhisattva vow be extended not only at the level of the social superorganism of groups of individual multicellular beings, but also downwards in the multiscale competency architecture to all the trillions of cells and microbes that inhabit each multicellular planetary body?
  • if it can, it can be interpreted as taking care of your body through
    • healthy exercise
    • healthy sleep
    • healthy diet
    • healthy thoughts and emotions
    • no self-harm
    • self love but not conceit
• what are the exact biological and evolutionary mechanisms that allow for coherence of individual organisms at the various levels of the multiscale competency architecture and can they be extended to apply to the scale of humans within a social superorganism scale?
• could love be another word for care drive that applies to all the different scales of the multiscale competency architecture?
• do feelings of love and compassion propagate downwards through the multiscale competency architecture and find analogous expression in the appropriate spaces?

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988303/

source: https://www.mdpi.com/1099-4300/24/5/710/htm

summary

• a trans-disciplinary attempt to develop a framework to deal with a diversity of emerging non-traditional intelligence from new bio-engineered species to AI based on the Buddhist conception of care and compassion for the other.
• very thought-provoking and some of the explanations and comparisons to evolution actually help to cast a new light on old Buddhist ideas.
• this is a trans-disciplinary paper synthesizing Buddhist concepts with evolutionary biology