33 Matching Annotations
  1. Jan 2024
    1. for - Rainbow body - Deep Humanity - superorganism - multi-level communication - adjacency between - contemplative practice - direct experience of body's cellular activity

      summary - Father Tiso and his catholic lineage combined with scholarship in Tibetan studies places him in a unique position for interfaith dialogue - His research interest in investigating the extraordinary and unexplained Tibetan meditation phenomena of Rainbow Body manifested by the greatest practitioners at the time of death (including contemporary ones) sheds light on the Rainbow Body phenomena in many spiritual traditions and challenges the scientific community to come up with an explanation for it. - If scientifically proven true, it offers an extraordinary possibility of human potential - Contemplation could be the practice technique that could directly bridge normal human consciousness with the microscopic world around us, which to date, is only accessible through scientific instrumentation.

      question - Does deep contemplative practice offers a direct access to the microscopic reality? - If so, how does it accomplish this direct communication with human cells, and indeed, even the universe itself? - Father Tiso shares centuries old recorded visual drawings of experiences reported by Rainbow Body practitioners and speculates whether these drawings represent direct experience of the cellular scale of our human form - Indeed, could it even be at the quantum level of experience, since rainbows are an optical phenomenal?

  2. Sep 2023
    1. It is hard to maintain the I-you distinction, and cooperation is massively favored. This is not because the agents have become less selfish, but because the size of the self (to which they are committed) has grown. For properly coupled cells, it is impossible to hide information from each other (from yourself) and it is impossible to do anything injurious to your neighbor because the same effects (consequences) will affect you within seconds.
      • for: cellular collaboration, gap junction, bioelectrical networks, bioelectric network

      • interesting fact: multicellular mechanisms to create coherence in competent constituent subunit cells

      • more research
        • very interesting mechanisms that mediate benefits of collective behavior of competent subunits within the biological body.
  3. Jul 2023
    1. Review coordinated by Life Science Editors Foundation

      Reviewed by: Dr. Angela Andersen, Life Science Editors Foundation

      Potential Conflicts of Interest: None

      Punch line: Activation of the yeast AMP-activated protein kinase (AMPK) negatively regulates MAGIC, inhibits the import of misfolded proteins into mitochondria & promotes mitochondrial biogenesis and fitness.

      Why is this interesting? Maybe all those healthy things like caloric restriction, intermittent fasting, exercise etc that activate AMPK & extend lifespan do so by inhibiting MAGIC & preventing mitochondrial damage from misfolded proteins.

      Background: Metabolic imbalance & loss of proteostasis are interconnected hallmarks of aging and age-related diseases. A mitochondria-mediated proteostasis mechanism called MAGIC (mitochondria as guardian in cytosol) concentrates cytosolic misfolded protein at the surface of mitochondria, where they are disaggregated by molecular chaperones, and then imported for degradation by mitochondrial proteases. Inhibition of this pathway prolongs protein aggregation in cytosol after proteotoxic stress, but excessive misfolded proteins in mitochondria can lead to mitochondrial damage.

      Results: • Genetic screen for MAGIC regulators uncovered 145 genes. Loss of Snf1 (AMPK homolog) led to increased mitochondrial import even without proteotoxic stress. In contrast indirect, constitutive activation of Snf1 (e.g. low glucose) prevented the import of misfolded proteins in mitochondria.

      • The data suggest that the reduced accumulation of misfolded proteins in mitochondria of Snf1-active cells is not due to enhanced intramitochondrial degradation nor to reduced levels of the misfolded protein, but rather due to blocked mitochondrial import.

      • Deletion of HAP4 counteracted Snf1 activation and overexpression of Hap4 alone recapitulated Snf1 activation. The Hap2/3/4/5 complex activates the expression of nuclear encoded mitochondrial proteins. Their data suggest that high expression of mitochondrial preproteins due to an elevated Snf1-Hap4 axis compete with misfolded proteins for mitochondrial import.

      • Proteotoxic stress led to a reduced growth rate & reduced mitochondrial fitness in high glucose medium but not under glucose limitation. The data suggest that low glucose, activation of Snf1 & prevention of misfolded protein import into mitochondria prevent the growth defect.

      • Many neurodegenerative disease-associated aggregation-prone proteins (α-synuclein, FUSP525L, TDP-43, amyloid beta, C9ORF72-associated poly(GR) dipeptide) are detected in mitochondria of human patients or disease models and impair mitochondrial functions. Their data suggest that the import of α-synuclein & associated reduction in mitochondrial fitness can be counteracted by indirect AMPK/Snf1 activation (i.e. glucose limitation).

      • Show data in yeast & human cells.

      Discussion: This paper revealed an unexpected link between cellular metabolism and proteostasis through MAGIC/mitochondria.

      • Snf1/AMPK is a key regulator of MAGIC & of misfolded protein import into mitochondria.

      • Snf1/AMPK balances the mitochondrial metabolic and proteostatic functions in response to glucose availability and protects mitochondrial fitness under proteotoxic stress.

      • The authors speculate that in high glucose, cells rely on glycolysis for ATP production and mitochondria ‘moonlighting’ in cellular proteostasis through MAGIC, but when glucose is limited and cells rely on oxidative phosphorylation for ATP generation, AMPK is activated and shuts down MAGIC, prioritizing the import of essential mitochondrial preproteins to ensure mitochondrial fitness and energy production.

      • Acknowledge limitations: Snf1/Hap4 activation elevates the expression of hundreds of mitochondrial preproteins, not clear whether specific preproteins or cytosolic factors directly involved in inhibiting mitochondrial import, & that more details on mechanisms will be of interest.

      • Caloric restriction & AMPK activation might contribute to lifespan extension by inhibiting MAGIC. In human, AMPK activity is elevated during health-benefitting activities such as exercise. Their data suggest that elevating AMPK activity may be beneficial in alleviating proteotoxicity associated with degenerative diseases - but hyperactivated AMPK has also been reported in several neurodegenerative diseases with proteostasis decline (Ang wonders- maybe AMPK is overwhelmed?).


      Future work - I can't wait to see the characterization of the ribosome biogenesis genes that they also pulled out as MAGIC regulators. Anticipating a translation, misfolded protein, mitochondria, aging axis :)

  4. Aug 2022
    1. Munro, A. P. S., Janani, L., Cornelius, V., Aley, P. K., Babbage, G., Baxter, D., Bula, M., Cathie, K., Chatterjee, K., Dodd, K., Enever, Y., Gokani, K., Goodman, A. L., Green, C. A., Harndahl, L., Haughney, J., Hicks, A., van der Klaauw, A. A., Kwok, J., … Appleby, K. (2021). Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): A blinded, multicentre, randomised, controlled, phase 2 trial. The Lancet, S0140673621027173. https://doi.org/10.1016/S0140-6736(21)02717-3 s

    1. Thuluva, S., Paradkar, V., Turaga, K., Gunneri, S., Yerroju, V., Mogulla, R., Kyasani, M., Manoharan, S. K., Medigeshi, G., Singh, J., Shaman, H., Singh, C., & Rao, A. V. (2022). Selection of optimum formulation of RBD-based protein sub-unit covid19 vaccine (Corbevax) based on safety and immunogenicity in an open-label, randomized Phase-1 and 2 clinical studies (p. 2022.03.08.22271822). medRxiv. https://doi.org/10.1101/2022.03.08.22271822

  5. Nov 2021
    1. Each new layer of Life is the result of what scientists call a major evolutionary transition? What was the cause of these transitions the answer is? Cooperation a Major Transition starts when free living creatures team up to form a cooperative group in the early stages of cooperation Participants are free to come and go as they [please] [if] a group sticks together long enough however 00:04:51 Division of labor will often evolve different participants begin specializing in different tasks as time goes on Individuals may become so specialized that they can no longer survive on their own [if] the entire group becomes locked into cooperation Depending fully on one another to survive and reproduce a new super organism has been forged and they made your evolutionary transition is complete 00:05:16 From this point on the entire group will evolve together as one Models describing natural situations that might promote the evolution of major transitions have been put forth by scientists such as John Maynard Smith [fior] Sonck Mary stuart West and w d hamilton using these models Researchers have been able to Mimic natural scenarios in the lab Allowing us to directly witness the beginnings of major transitions [evolved]

      This is the key to Major Evolutionary Transition - a population of free living individual creatures discover that in teaming up, there is a greater resultant evolutionary fitness, mutualism symbiotic relationship emerges. It becomes so strong over time that the many become a self-replicating one.

      The biological self is always defined by a boundary between inner and outer, but in this act of mutualism, the many biological selves join to form a new higher order biological self.

      In this way, a multi-cellular species like ours is somewhat like one of those nested Russian dolls.

      Indeed, Amanda Robins hypothesizes


      that our species has undergone what she and Peter Nonacs calls Major System Transition (MST). The cultural artifact of inscribed language has made possible a superorganism / supraorganism that has spread across the globe.

    2. Today we tend to shrug this off as common knowledge, but think how amazing this is you are a Colony

      This is a great vid for showing how we are a multi-level being. Within this human body, we embed 4 different stages of Major Evolutionary Transitions (MET).

      Our human body is the product of billions of years of evolution, embodying various outputs from each major stage of a Major Evolutionary Transition (MET). We are a multi-cellular being, a colony. Yet,at the same time, we have living elements that at one time in history, were independent living beings which were NOT part of a multi-cellular colony!

      We have genes, that were once autonomous living entities, mitochondria within cells, which at one time were autonomous entities, and cells, which were also once autonomously existent eukaryotes. All three exist in transmuted form that is now integrated into our body.

  6. Sep 2021
  7. Jul 2021
  8. May 2021
  9. Mar 2021
    1. Technological advances have reduced the footprint of communications equipment, making it possible to fit cellular and satellite components into one device, which keeps equipment costs down
  10. Nov 2020
    1. ATP

      ATP better known as Adenosine triphosphate is an energy carrying molecule found in all living things cells. ATP takes the chemical energy from the process of breaking down food molecules to releases it as fuel for cellular processes.

  11. Sep 2020
  12. Aug 2020
    1. Ferretti, A. P., Kula, T., Wang, Y., Nguyen, D. M., Weinheimer, A., Dunlap, G. S., Xu, Q., Nabilsi, N., Perullo, C. R., Cristofaro, A. W., Whitton, H. J., Virbasius, A., Olivier, K. J., Baiamonte, L. B., Alistar, A. T., Whitman, E. D., Bertino, S. A., Chattopadhyay, S., & MacBeath, G. (2020). COVID-19 Patients Form Memory CD8+ T Cells that Recognize a Small Set of Shared Immunodominant Epitopes in SARS-CoV-2. MedRxiv, 2020.07.24.20161653. https://doi.org/10.1101/2020.07.24.20161653

    1. Glasgow, A., Glasgow, J., Limonta, D., Solomon, P., Lui, I., Zhang, Y., Nix, M. A., Rettko, N. J., Lim, S. A., Zha, S., Yamin, R., Kao, K., Rosenberg, O. S., Ravetch, J. V., Wiita, A. P., Leung, K. K., Zhou, X. X., Hobman, T. C., Kortemme, T., & Wells, J. A. (2020). Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. BioRxiv, 2020.07.31.231746. https://doi.org/10.1101/2020.07.31.231746

    1. Clausen, T. M., Sandoval, D. R., Spliid, C. B., Pihl, J., Painter, C. D., Thacker, B. E., Glass, C. A., Narayanan, A., Majowicz, S. A., Zhang, Y., Torres, J. L., Golden, G. J., Porell, R., Garretson, A. F., Laubach, L., Feldman, J., Yin, X., Pu, Y., Hauser, B., … Esko, J. D. (2020). SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. BioRxiv, 2020.07.14.201616. https://doi.org/10.1101/2020.07.14.201616

  13. Jul 2020
    1. Yurkovetskiy, L., Wang, X., Pascal, K. E., Tomkins-Tinch, C., Nyalile, T., Wang, Y., Baum, A., Diehl, W. E., Dauphin, A., Carbone, C., Veinotte, K., Egri, S. B., Schaffner, S. F., Lemieux, J. E., Munro, J., Rafique, A., Barve, A., Sabeti, P. C., Kyratsous, C. A., … Luban, J. (2020). Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant. BioRxiv, 2020.07.04.187757. https://doi.org/10.1101/2020.07.04.187757

  14. Jun 2020
  15. Oct 2019
  16. Jan 2018
    1. The lower the frequency of the band the further it can travel, so the 800MHz band is the most adept of the three at travelling over long distances, which means users can get a 4G signal even when they’re a long way from a mast. This becomes particularly useful in rural areas where masts are likely to be quite spread out.

      Hmm? I assumed 4G was lower range than 3G. From what I read here, 4G can work at a longer range, with lower capacity, scenarios and work at shorter range, high capacity scenarios.

      But only if the cell phone provider has both low frequencies and high frequencies