8 Matching Annotations
  1. Nov 2021
    1. So to sum things up what caused life's major evolutionary transitions the answer is cooperation major transitions begin when a group of organisms join forces to better survive and reproduce if cooperation continues long enough a new super organism may Emerge one that can then go [on] to reproduce and evolve as a whole and 00:07:42 The pathway that led [to] animals along with humankind [at] least three major transitions have been identified resulting in four layers of Life within your own body

      Within this human body, we embed 4 different stages of Major Evolutionary Transitions (MET).

      Our human body is the product of billions of years of evolution, embodying various outputs from each major stage of a Major Evolutionary Transition (MET). We are a multi-cellular being, a colony. Yet,at the same time, we have living elements that at one time in history, were independent living beings which were NOT part of a multi-cellular colony!

      In the deep history of the evolution of the human body, genes, mitochondria, eukaryotes were all once autonomous living entities, each a biological self with its own boundary separating inner from outer. Virus's helped to catalyze their mutualism over deep time.

      Now, over billions of years of evolution, they are all integrated together by the extra-cellular matrix and laminin protein into our multi-cellular human body, replicating as one super, super, super organism.

      Finally, inscribed language has allowed us to undergo another kind of transition, a major system transition (MST) where human beings now dominate the entire biosphere, for better and for worse.

  2. Jul 2019
  3. Jun 2019
    1. KMO is located in the outer mitochondrial membrane.

      So, this entire pathway, or segment, is dependent on mitochondria

    2. targets is PPARγ, presumably being a major signalling pathway involved in neuroinflammation

      All of the above is great info and there are many suspects, the main current is PPARgamma. TheNrf pathways hold quite a bit of niftiness in the translation regulation, cap dependent, independent proteins and folding. Seeking some connection to, causative agent to the age related and stress related cascade hinges on mitochodria in some, (it certainly has its finger in the pie-- but so do many root level processes) Part of my diligence in the mito domain is the Anti-Streetlight effect. That is, we have looked everywhere else and, yes, tehre are constantly new revelations, but these areas of mitochondria gentics, translational regulation and defects(both-not all "errors" are errors), and ribosomal and tRNA changes have been excluded from research and thought to be mechanistis and stable non-changing variables.And now, that they are known to be ariable...muchwill have to be reevaluated

    1. In 99.3% of the time under unstressed conditions,

      Danism: A cell in a diseased state does not respond the same way as a cell in a non-diseased state. This is essential and has many roots. Translation Regulation being the most controversial.

    2. PRDX5 being present in the mitochondrion,
    3. CysP sulfhydryl

      keep track of this sulfur molecule. It has turned up in other areas.

  4. Nov 2013