7 Matching Annotations
  1. Feb 2019
    1. Despite the fact that some environmentally induced changes are heritable, these effects are not stable [30Becker C. Weigel D. Epigenetic variation: origin and transgenerational inheritance.Curr. Opin. Plant Biol. 2012; 15: 562-567Crossref PubMed Scopus (62) Google Scholar]. Specifically, it has been shown that in large populations of Arabidopsis most ‘epi-mutations’ are labile — after only a few generations, these base-pair methylations revert to their original state. Hence, epigenetic modifications in plants are of very limited significance for evolutionary processes. Accordingly, neo-Lamarckian (including Lysenkoist) concepts have been experimentally refuted by these trans-generational epigenetic analyses [30Becker C. Weigel D. Epigenetic variation: origin and transgenerational inheritance.Curr. Opin. Plant Biol. 2012; 15: 562-567Crossref PubMed Scopus (62) Google Scholar].

      Just one citation and that to an opinion article? Interesting...

  2. Jun 2018
    1. Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs

      Queuosine metabolite necessary for DNMT2-induced tRNA modification; salvaged from bacteria of microbiome

  3. Jan 2018
  4. Dec 2017
  5. Nov 2017
  6. Apr 2017
    1. while those that had been moved to 25 degrees had largely lost the methylation tags. Importantly, they still maintained this reduced histone methylation when moved back to the cooler temperature, suggesting that it is playing an important role in locking the memory into the transgenes.

      Could it be that the genetic background (or importantly surrounding environment or cross talk among cells) in the first generation that were exposed to 25 C temp might have changed, and conditioned subsequent generations?

      After 14 generations, secondary changes in the propoagated genetic makeup (including cross talk) could have reverted phenotype and reset histone marks to repress gene expression.

      See if how often c.elegans mutate or show CN changes, i.e., background vs stress induced by temp changes?

    2. Worms are very short-lived, so perhaps they are transmitting memories of past conditions to help their descendants predict what their environment might be like in the future,

      ? as long as cost, e.g., energy consumption for propagating such beneficial features is not higher than needed for one's survival.