28 Matching Annotations
  1. Sep 2022
    1. Also be aware of how Ruby handles aliases and inheritance: an alias references the method that was resolved at the time the alias was defined; it is not dispatched dynamically.
    1. an increasing share of adaptive information is stored in culture compared with genes.

      !- feature : culture-driven human inheritance - more adaptive information is being stored in culture than in genes

    2. It follows, then, that humans are experiencing an evolutionary transition in individuality from single human to cultural group because culture is replacing genes as the primary human inheritance system, and cultural adaptations are heavily group structured.

      !- Question : culture-driven human inheritance - How do progress traps fit into this, as opposed to genetic-driven inheritance?

    3. culture is gradually replacing genetics as the primary human system of inheritance. This hypothesis helps clarify the human ETI.

      !- conclusion : GCC - very important finding - nobody knows the implications of such a profound shift - it means we are profoundly dependent on culture, on artificial human-created adaptations for our survival !- in other words : GCC - we no longer genetically evolve to adapt, but rather cognitive create solutions to adapt!

  2. Aug 2022
  3. Jul 2022
    1. These directives are inherited from the previous configuration level if and only if there are no proxy_set_header directives defined on the current level.

      This conditional rule for inheritance is different than most other apps/contexts. Usually it just always inherits, and any local config at the current level gets merged with or overrides what is inherited.

  4. May 2022
    1. DICER1 syndrome is a rare genetic condition predisposing to hereditary cancer and caused by variants in the DICER1

      GeneName: DICER1 PMCID: PMC7859642 HGNCID: Unavailable Inheritance Pattern: Autosomal dominant. Disease Entity: Familial pleuropulmonary blastoma (PPB), cervix embryonal rhabdomyosarcoma, multinodular goiter, nasal chondromesenchymal hemartoma, Ciliary body medulloepithelioma, Sertoli-Leydig Cell Tumor (SLCT), differentiated thyroid carcinoma, pituitary blastoma, pineoblastoma, cystic nephroma, Wilm's tumor and sarcomas of different sites including, amongst others, the uterine cervix, kidney and brain. Mutation: Germline Zygosity: Heterozygose Variant: No ClinVarID present. Family Information: No family outline Case: No specified information of patients included. CasePresentingHPO's: n/a CasePrevious Testing: n/a gnomAD: n/a Mutation Type: nonsense, frameshift, or splice affected.

    1. Pathogenic germline variants in DICER1 underlie an autosomal dominant, pleiotropic tumor-predisposition disorder.

      gene name: DICER 1 PMID (PubMed ID): 33570641 HGNCID: n/a Inheritance Pattern: autosomal dominant Disease Entity: benign and malignant tumor mutation Mutation: somatic Zygosity: heterozygous Variant: n/a Family Information: n/a Case: people of all sexes, ages, ethnicities and races participated CasePresentingHPOs: individuals with DICER1-associated tumors or pathogenic germline DICER1 variants were recruited to participate CasePreviousTesting: n/a gnomAD: n/a

    1. DICER1 syndrome is an autosomal-dominant,pleiotropic, tumor-predisposition disorder arisingfrom pathogenic germline variants in DICER1, whichencodes an endoribonuclease integral to processingmicroRNAs

      DICER1 is the gene name. PubMed ID, HGCNCID, and Variant: I can't find Inheritance Pattern: autosomal-dominant The disease entity: DICER1 syndrome The type of mutation: germline. Zygosity: not known. Family Information: a family was used, DICER1 carriers, and non DICER1 variant used, some of the family members had tumors from DICER1 Case Information: mean age is 34, the range of age is 18.6 to 43 years, male, and female used, ethnicity can't find Case Presenting HPO: cancer testing, chemotherapy, radiotherapy gnomeAD: 9.2,8.3.2 Mutation type: Pleiotropic, loss of function, missense

  5. Apr 2022
    1. DICER1 syndrome is a rare genetic condition predisposing to hereditary cancer and caused by variants in the DICER1 gene.

      Gene Name: DICER1 PMID:33552988 HGNCID: Unavailable Inheritance Pattern:Autosomal Dominant Disease Entity: familial pleuropulmonary blastoma (PPB),cystic nephroma, ovarian Sertoli-Leydig cell tumor (SLCT), multinodular goiter, cervix embryonal rhabdomyosarcoma, Wilms’ tumor, nasal chondromesenchymal hamartoma, ciliary body medulloepithelioma, differentiated thyroid carcinoma, pituitary blastoma, pineoblastoma, and sarcomas of different sites. Mutation: Nonsense, Frameshift<br /> Zygosity: Heterosygosity Variant:No ClinVar ID present Family Information:no diseases mentioned in family Case: no specified case in this article gnomAD: n/a Mutation type: Nonsense. frameshift

    1. The DICER1 syndrome is an autosomal dominant tumor‐predisposi-tion disorder associated with pleuropulmonary blastoma, a rare pediatric lung cancer

      GeneName:DICER1 PMID (PubMed ID): PMCID: PMC6418698 PMID: 30672147 HGNCID: NOT LISTED<br /> Inheritance Pattern: Autosomal Dominant Disease Entity: Cancer; benign and malignant tumors including pleuropulmonary blastoma, cystic nephroma, Sertoli-Leydig cell tumors, multinodular goiter, Thryoid cancer, rhabdomyosarcoma, and pineoblastoma. Mutation: Somatic missense variation Mutation type: missense Zygosity: None stated Variant: unregistered…. Family Information: Characterize germline variants in familial early-onset clorectal cancer patients; The observation of germline DICER1 variation with uterine corpus endometrial carcinoma merits additional investigation. CasePresentingHPOs: uterine and rectal cancers in germline mutation

  6. Oct 2021
  7. Jul 2021
  8. Apr 2021
  9. Mar 2021
    1. Internally, it creates and returns a fresh, subclassed activity (via patching) whilst replacing the step for given :id. Be advised that this does not change the original activity class.
  10. Feb 2021
    1. In order to customize the latter one and add another step tidy_storage, you’d normally have to subclass all three activities and override steps.
  11. Jan 2021
    1. To many people, polymorphism is synonymous with inheritance. But it’s actually a more general concept that refers to code that can work with data of multiple types. For inheritance, those types are generally subclasses. Rust instead uses generics to abstract over different possible types and trait bounds to impose constraints on what those types must provide. This is sometimes called bounded parametric polymorphism.
  12. Oct 2020
    1. Informative data about objects that are considered prototypes for the role. Base concept is similar to type, but without inheritance of limitations and properties. Base concepts are designed as a substitute for inheritance for external concepts. A base concept is like a related concept except that the base concept is almost identical to the role definition.
  13. Oct 2019
  14. Jun 2018
    1. Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs

      Queuosine metabolite necessary for DNMT2-induced tRNA modification; salvaged from bacteria of microbiome

  15. Oct 2015
    1. We Inherit Our Ample Patrimony

      by the power of development or maldevelopment in a respect to the resource consumption and destruction of the natural world through means of an unadulterated truth: Patrimony exists without problems. Recurring/self perpetuating lineage

  16. Feb 2014
    1. The conservative influence of property does not, however, depend on primogeniture or even inheritance -- features that gave property a valuable role in Burke's political system as well as in the political theories advanced by Hegel and Plato. n11 Within a single lifetime, property tends to make the property owner more risk-averse. This aversion applies both to public decisions [*291] affecting property, such as taxes, and to personal decisions that might diminish one's property, such as investment strategies and career choices. Inheritance and capital appreciation are only additional characteristics of traditional notions of property that tend to stabilize social stratification.