7 Matching Annotations
  1. Dec 2018
    1. The Heads Up Health web app is designed specifically to help you track ketones alongside all of your other vital health data.
    2. urine strips test for unused acetoacetate rather than the main ketone that our body does use, B-hydroxybutyrate.
    3. Why Measuring Ketones MattersBeing able to frequently and accurately measure the level of ketosis can be important for those following the ketogenic diet for clinical purposes as well as for overall health and performance. Due to individual variability in response to different types of food, having frequent feedback will aid individuals towards improving their understanding of how their body responds while increasing motivation and adherence.
    4. Zhou, W., Mukherjee, P., Kiebish, M. A., Markis, W. T., Mantis, J. G., & Seyfried, T. N. (2007). The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer. Nutrition & metabolism, 4(1), 5.
    5. More specific for those following a ketogenic diet, to date, six studies have compared breath acetone levels with blood b-hydroxybutyrate levels and have found a strong correlation (R2= 0.77) (8). One study in particular directly compared blood, breath, and urine samples of 12 healthy individuals undergoing an experimental protocol designed to induce a state of ketosis. The results demonstrated that plasma acetoacetate was best predicted by breath acetone (6). Therefore, it appears that breath acetone assessments are a fast and accurate way to test for the degree of ketosis.
    6. When following a ketogenic diet, acetyl-CoA is produced in the liver from the breakdown of fat and is used to produce acetoacetate, one of three ketone bodies.  From there, acetoacetate can be converted to the other two “ketone bodies”, b-hydroxybutyrate and acetone.  While b-hydroxybutyrate is tested via blood meters, acetone actually diffuses into the lungs and can be measured by testing exhaled breath (7)! Acetone is a byproduct of fat metabolism and is present in the breath of all humans but in different concentrations.
    1. To reduce the urinary loss of these important metabolicfuels, which furnish a significant amount of the caloric re-quirements during fasting, the kidney is capable of reab-sorbing a portion of the increased filtered load of ketoacids.A linear correlation has been found between the urinaryexcretion of acetoacetate and the plasma concentration, oncethe renal threshold has been exceeded.

      This seems to indicate that when the body no longer needs ketones it will excrete the excess via the urine.