In fact, only 2.3% of the serous and none of 24 mucinous carcinomas harbored somatic PIK3CA mutations compared with 20% of the endometrioid and clear cell ovarian cancers indicating that the major histologic subtypes such as serous, endometrioid, clear cell and mucinous may arise through different pathways.

Individuals who harbor germline pathogenic variants in DICER1 (MIM #601200) have an increased risk for a variety of benign and malignant tumors.

Of 64 females aged 2–72 years, fifteen underwent treatment for pleuropulmonary blastoma as children and three were treated for cervical embryonal rhabdomyosarcoma.