the token used to send push notifications isn't immediately invalidated when an app is deleted. And since the server has no way of knowing whether the app is still installed after the last notification it sent
令人惊讶的是：用于发送推送通知的令牌在应用被删除后并不会立即失效。由于服务器无法知道应用是否仍在安装，它可能会继续推送通知，而iPhone则决定是否显示这些通知。这一机制为执法机构提供了在应用被删除后仍可能获取消息的技术可能性，而大多数普通用户对此毫不知情。
The proband
Case#:case 1 II:4
DiseaseAssertion: Stargardt disease (STGD1)
FamilyInfo: mother has identical phenotype as proband, dad and sister asymptomatic, brother was symptomatic at 8 years old, other brother symptomatic at 15 years old.
CasePresentingHPOs: HP:0000007
CaseHPOFreeText: at age 50, with central visual imparement in right eye, 20/40 right, 20/20 left, linear and branching hyperautofluorescent subretinal deposits and extrafoveal RPE atrophy in both eyes,
CaseNotHPOs: n/a
CaseNotHPOFreeText: n/a
Genotyping Method:
PreviouslyPublished: n/a
Variant: c.6031_6044delins18M/p.(Ile2003LeufsTer41)
ClinVar: not found
CAID: not found
SupplementalData:
Phenotype–genotype correlations in a pseudodominant Stargardt disease pedigree due to a novel ABCA4 deletion–insertion variant causing a splicing defect
PMID: 32627976
Gene: ABCA4
HGNC ID: 34
Disease: Von-willebrand Disease (Type 2A)
Patient: 50 yo female
Variant: VWF NM_000552.5 c:4232_4249del p.(Val411_Ile416del), Exon 28, heterozygous variant
According to this paper, ACMG-AMP guidelines for interpreting this variant resulted in classification of likely pathogenic
Phenotypes: increased bruising, fatigue, recurrent sinusitis, menorrhagia, neutropenia, anaemia. Reduction in high-molecular-weight multimers
Family: segregation analysis showed two affected family members had the variant and two unaffected family members did not have variant.
Note: Patient also has diagnosed Acute Myeloid Leukaemia (AML) NM_000546.6(TP53):c704A>G p.(Asn235Ser), listed as VUS and found by NGS
Disease: Von Willebrand Disease (VWD)
Patient: 18 yo, Male, heterozygote
Variant: VWF NM_000552.5: c.5456_5842del p.(R1819_C1948delinsS)
Was not present in gnomAD when searched
Dominant negative effect
Phenotypes:
lower collagen-binding capacity
History of bleeding (epistaxis)
gum bleeding
cutaneous bruises
ADAMTS13 resistant
Family: Mother, father, sister are asymptomatic
Suggested as de novo, no picture found in patient's relative of the deletion, loss of A3 loop
Ironically, data brokers need to collect additional info to verify your identity and ensure they’re deleting the right person’s data.
What if I don’t live in California?Only California residents have the right to data deletion under CCPA. (Why companies have the right to your data and you do not is another story. And here’s another. And another.)But some companies have said they’ll honor deletion requests no matter where you live. Spotify, Uber and Twitter said they treat deletion requests from any geographic location the same. Netflix, Microsoft, Starbucks and UPS have also said they’ll extend CCPA rights to all Americans.
The company will probably ask for you to send over additional information or set up an appointment to verify your identity — that’s so no one can pretend to be you and steal or delete your data. To verify, you may need to confirm your account username and password, provide a piece of data like your phone number for the company to cross-check, or, rarely, show your government-issued ID. You should never be required to set up an account to get your data deleted, according to CCPA.
People have to verify their identities before companies can delete data, which poses an extra obstacle.
Nobody can see deleted accounts - not even developers. Deleted accounts are fully deleted. There's nothing to see basically by definition.
There is no active user with that ID, so you cannot search by it. The whole point of deleting an account is to make it inaccessible, unreferenced, and unlinked. We're not going to implement "soft" account deletion.
You cannot. And you're not supposed to. When an account is deleted, it is disassociated from all existing posts by design.
The industry’s first standard for handling user data deletion requests
notify any third party, or service provider to which the covered entity transferred such covered data of the individual’s deletion request
Deletion requests propagate?
GeneName: DICER1 syndrome (pleuropulmonary blastoma familial tumor susceptibility syndrome), PMID (PubMed ID): 29762508, HGNCID: 17098, Inheritance pattern: autosomal-dominant disease, Disease entity: Plueropulomary Blastoma, Mutation: Somatic, Zygosity: heterozygous, Variant: multiple variants, Family information: NA, Case: young children, CasePresentingHPO: N/A, CasePreviousTesting: N/A, Gnomade #: N/A , Mutation type: deletion
Individuals who harbor germline pathogenic variants in DICER1 (MIM #601200) have an increased risk for a variety of benign and malignant tumors.
GENENAME: DICER1 PMID: 31952842 HGNCID: NONE DISEASE ENTITY: THYROID DISEASE AND OVARIAN TUMORS ZYGOSITY: HETEROZYGOUS VARIANT: NONE CASE PRESENTING HPOS: cervical embryonal rhabdomyosarcoma CASE PREVIOUS TESTING: GYNECOLOGIC HISTORY MUTATION: DELETION
The NFS version 3 protocol is designed to allow servers to be as simple and general as possible. Sometimes the simplicity of the server can be a problem, if the client implements complicated file system semantics. For example, some operating systems allow removal of open files. A process can open a file and, while it is open, remove it from the directory. The file can be read and Callaghan, el al Informational [Page 96] RFC 1813 NFS Version 3 Protocol June 1995 written as long as the process keeps it open, even though the file has no name in the file system. It is impossible for a stateless server to implement these semantics. The client can do some tricks such as renaming the file on remove (to a hidden name), and only physically deleting it on close. The NFS version 3 protocol provides sufficient functionality to implement most file system semantics on a client.
El síndrome de deleción 22q11.2 es un síndrome de genes contiguos con una incidencia de un caso por cada 4.000-6.000 recién nacidos. Posee una amplia variabilidad clínica y sus características clínicas más frecuentes son cardiopatía conotruncal, anomalías palatinas, hipocalcemia, problemas de inmunidad y de aprendizaje, y un fenotipo facial característico. El objetivo de este estudio es revisar las formas de presentación y las manifestaciones clínicas de los niños con deleción 22q11.2 como guía para su diagnóstico precoz.
Incidencia 4000 q 6000 RN