THC-piperine-PNL which resulted in a 9.3-fold increase in AUC as compared to THC solution.
While this is impressive, it doesn't mean ten times the effect given that the active metabolite is being limited by the piperine. It does, however, suggest that oral bioavailability of THC can potentially be on par with or superior to pulmonary administration.
Here we use piperine, curcumin and resveratrol to formulate the Advanced-PNL formulations.
I'll need to read up on why they used curcumin and resveratrol. I was also planning to use curcumin because it stimulates bile release. That may be their reason as well. They used piperine because it inhibits p450 enzymes. I'm not sure why they might have used resveratrol, though I do recall hearing that it is a bioenhancer.
What gets u high in marijuana is called THC.
Marijuana kills cancer cells in proportion to its dose and duration of treatment, researchers found, and whole plant cannabis rich in THC was more efficacious than pure, lab-grade THC alone.
We clearly have a lot to learn about cannabinoids and terpenes. There are maybe medical breakthroughs to be made here, breakthroughs that have been delayed for decades by reactionary, draconian drug laws.