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  1. Nov 2024
    1. how some lives are made small so thatothers may grow.

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    1. Eine neue Studie bestätigt, dass die Hauptursache des immer schnelleren Anstiegs des Methan-Gehalts der Atmosphäre die Aktivität von Mikroaorganismen ist, die durch die globale Erhitzung zunimmt. Damit handelt es sich um einen Feedback-Mechanismus, durch den sich die globale Erhitzung selbst verstärkt. https://taz.de/Zu-viel-Methan-in-der-Atmosphaere/!6045201/

      Studie: https://www.pnas.org/doi/10.1073/pnas.2411212121

      Vorangehende Studien: https://www.nature.com/articles/s41558-023-01629-0, https://www.nature.com/articles/s41558-022-01296-7.epdf?sharing_token=CDMa5-ti34UNBqv3kfuCB9RgN0jAjWel9jnR3ZoTv0NZRKXEI-7kyXEEvNI7duu65JLcZpmhGxWTeSfYcMCqxqYk5nUrdR60izmjToMNw56RgBqIcn3JXKxSjx13vmB9ZYndGTUMt-52Vs7HT_T6K9Oth4QFRyP51eOpz8pV8l65HFDo2VSfQ6xDXklMtmvt-HGwltAINb_2xgmtAR-V4g%3D%3D&tracking_referrer=taz.de

  2. Oct 2024
    1. The research finds

      for - stats - green growth - 2024 - Global South vs Global North

      stats - green growth - 2024 - Global South has - 60% of world population - 20% of fossil fuel production - fossil fuel production in decline - 70% of global renewable resource potential - In 2024, 87% of capex of electricity generation is renewable - From 2019 to 2024, renewable energy has grown 23% annually and now supplies 9% of its electricity - 17% of Global South has already overtaken Global North in % of renewable electricty generation

    2. for - Report - Powering Up the Global South - Rocky Mountain Institute - RMI - 2024 - Vikram Singh - Kingsmill Bond

      Summary - This report shows that the Global South is adopting cleantech faster than the Global North

  3. Aug 2024
  4. Jul 2024
    1. The trees with deep roots are the ones that grow tall. — Frédéric Mistral

      original source?


      This quote works well for individuals, but looking at tree stands in Alaska only thousands of years from glaciation, one sees incredibly tall trees that have shallow root systems, but they utilize each others' root systems to keep groups of trees strong and tall. This apparently even extends to groups of trees looking out for each other to keep the group strong.

      via https://www.saschafast.de/

    1. After relevance comes the "plateau period" where a lot of practice is being done with a lot of mistakes; there seems to be little progress. Most people give up here.

      You need a growth mindset and just continue.

    1. for - economic growth - physical limits to - reductio ad absurdum - physical absurdity of continuing current energy and waste heat trends into the near future

      paper details - title - Limits to Economic Growth - author - Thomas W. Murphy Jr. - date - 21 July, 2022 - publication - Nature Physics, comment, online - https://doi.org/10.1038/s41567-022-01652-6

      summary - Physicist Thomas W. Murphy employs reductio ab adsurdium logic to prove the fallacy of the assumptions of his argument - In this case, the argument is that we can indefinitely continue to sustain economic growth at rates that have held steady at about 2-3% per annum since the early 1900s. - Using both idealistic and simplified energy and waste heat calculations of energy and waste heat compounding at 2-3% per annum (or 10x per century), Murphy shows the absurd conclusions of continuing these current trends of energy and waste heat emissions on a global scale. - The implications are that physics and thermodynamics will naturally constrain us to plateau to a steady state economy in which the majority of economic activity needs to not depend on physically intensive

      from - Planet Critical podcast - 6th Mass Extinction - interview with science journalist Peter Brannen - https://hyp.is/66oSJD-AEe-rN08IjlMu5A/docdrop.org/video/cP8FXbPrEiI/

    2. An examplein the energy domain demonstrates theabsurdity of indefinite growth in the physicalrealm.

      for - absurdity of indefinite economic growth - energy projection example of recent energy trends

      -absurdity of indefinite economic growth - energy projections - Energy growth has typically been 2–3% per year since early 1900's. - This is approximately equivalent to 10x each century - Present-day energy output is 18 TW and extrapolates to - - approx.100 TW in 2100, - approx. 1,000 TW in 2200, etc. - In 400 years, from today, we would exceed the total solar power incident on Earth - In 1300 years from today, we would exceed the entire output of the Sun in all directions - In 2400 years from today, we would exceed the energy output of all 100 billion stars in the Milky Way galaxy - This last jump is made impossible by the fact that even light cannot cross the galaxy in fewer than 100,000 years. - Hence, physics puts a hard limit on how long our energy growth enterprise could possibly continue

    3. Continued economic growth in the faceof steady-state physical resources wouldrequire all growth to be effectively in thenon-physical sector, possibly assisted bymodest efficiency improvements in howwe use physical resources.

      for - decoupling - economic growth from - physical resources

    4. Given that assumptions of quantitativegrowth are pervasive in our society andhave been present for many generations,it is perhaps not surprising that growth isnot widely understood to be a transientphenomenon. Early thinkers on the physicaleconomy, such as Adam Smith, ThomasMalthus, David Ricardo and John Stuart Millsaw the growth phase as just that: a phase9

      for - quote - economic growth - pioneering economists saw growth not as permanent, but as just a temporary phase

      quote - economic growth - pioneering economists saw growth not as permanent, but as just a temporary phase - (see below) - Given that - assumptions of quantitative growth are pervasive in our society and - have been present for many generations, - it is perhaps not surprising that growth is not widely understood to be a transient phenomenon. - Early thinkers on the physical economy, such as - Adam Smith, <br /> - Thomas Malthus, - David Ricardo and - John Stuart Mill - saw the growth phase as just that: a phase

    5. Another way to frame physicallimitations to growth is in terms of wasteheat, which is the end product of nearlyall energetic utilization on Earth.

      for - absurdity of indefinite economic growth - waste heat projection example of recent waste heat trends

      absurdity of indefinite economic growth - waste heat projection example of recent waste heat trends - At present, the waste heat term is about four orders of magnitude smaller than the solar term. - But at a growth factor of ten per century, they would reach parity in roughly 400 years. - Indeed, the surface temperature of Earth would reach the boiling point of water (373 K) in just over 400 years under this relentless prescription.

    1. this very elegant uh argument made by this I think he is a uh he's a physicist I 00:46:11 think at UC San Diego Tom Murphy where he's like even even if you take the most conservative relationship between energy use and economic growth and you plot it out a couple hundred years from now then 00:46:26 the economy is producing so much waste heat that the oceans will be boiling off and in in a thousand years you're like the economy is producing so much waste heat that it's more energy than is put 00:46:38 out in the sun in all directions

      for - limits to economic growth - physics calculations - by Tom Murphy show absurdity of continual growth - energy and waste heat perspective

      to - Nature Physics - LImits to Economic Growth - Tom Murphy - https://hyp.is/CM3Grj9_Ee-obTc6jrPBRA/tmurphy.physics.ucsd.edu/papers/limits-econ-final.pdf

  5. Jun 2024
    1. this is where we can see the doubling time of the global economy in years from 1903 it's been 15 years but after super intelligence what happens is it going to be every 3 years is it going be every five is it going to 00:33:22 be every year is it going to be every 6 months I mean how crazy is the growth going to be

      for - progress trap - AI triggering massive economic growth - planetary boundaries

      progress trap - AI triggering massive economic growth - planetary boundaries - The podcaster does not consider the ramifications of the potential disastrous impact of such economic growth if not managed properly

    1. Achieving net-zero carbon emissions by 2050 will require a whopping 460% increase in copper production, which will require 194 new large-scale mines to be brought online over the next 32 years.

      for - green growth - mineral and metal shortages

      green growth - mineral and metal shortages

      • Achieving net-zero carbon emissions by 2050 will require
        • a whopping 460% increase in copper production,
        • which will require 194 new large-scale mines to be brought online over the next 32 years.
    1. The worry most people have with this suggestion is that children are going to get discouraged if they fail. But that is not necessarily the case, and I think teachers, parents, and other adults have a great opportunity to help prevent this. If we demonstrate that needing to put down a book for awhile is not a failure, then we can help children become more willing to experiment and to try things which are currently just out of reach.

      This is the concept of growth mindset; and we need to teach that to our children in any way possible. It has been shown in studies that growth mindset has a positive causal influence on academic and financial success (I cannot state sources, but I know I've come across this)

      Note to self: Research this later.

  6. May 2024
    1. on a vraiment de quoi au niveau 00:20:48 scientifique on a de quoi prouver que agir sur l'état d'esprit de développement c'est possible et ça a des effets sur la réussite scolaire des élèves
    2. deuxième point très important c'est le déficit de ces compétences parmi les élèves français alors là je vais parler que des élèves 00:09:59 mais sachez puisque nous sommes des adultes que ça vaut aussi pour nous les adultes les enquêtes auprès des adultes qui sont menées notamment l'enquête PIAC qui est mené par l'OCDE également auprès des adultes montre à peu près exactement 00:10:11 les mêmes déficites he il y a pas de miracle à 18 ans on devient pas complètement différent de ce qu'on de ce qu'on voit chez les adolescents donc par exemple sur l'état d'esprit de développement euh ici ce que je vais représenter donc la la ligne noire c'est 00:10:25 la moyenne de tous les pays de l'OCDE d'accord donc on a standardisé et en fait chaque bâton représente un pays et le pays qui est en gras et la France donc ce qu'on voit c'est que la France 00:10:37 est en dessous de la moyenne des pays de l'OCDE concernant le score d'état d'esprit de développement donc la croyance que l'intelligence c'est quelque chose qui peut évoluer et qui peut s'entraîner et se développer en 00:10:50 fait donc justement c'est important qu'on sache que c'est vrai que l'intelligence peut se développer pour que en fait normalement 100 % des gens g devrai répondre oui d'accord devrait avoir un score d'état d'esprit de 00:11:02 développement vous pourriez vous dire bah oui mais en fait les élèves français ils ont raison ils sont beaucoup plus lucid que les autres non ce n'est pas le cas en fait quand on a un état d'esprit de développement qui n'est enfin quand on ne pense pas que l'intelligence pe 00:11:15 peut se développer on a tort scientifiquement parlant et donc donc la France est plutôt du côté des pays déficitaires
    1. "The great books are the inexhaustible books. The books that can sustain a lifetime of reading."

    2. "The great books are the books that never have to be written again. They are so good no-one can try to write them again."

    3. "The great books are the books that everyone wants to have read but no-one wants to read."

    4. What did not stand out to me before while reading the book, but does now when watching this, is the fact that the greatest books are subjective to each individual... Meaning my list might not be the same for others.

    5. Very fascinating thought experiment. Out of the 140+ books I have read so far only a few, less than a handful, would fit the list of "growth" books; the greatest, that I would take to the deserted island for 10 years...

      1. The Bible
      2. Antonin Sertillanges' The Intellectual Life: Its Spirit, Method, Conditions
      3. Marcus Aurelius' Meditations

      No other book, to my mind, that I have read so far would cut it to my list.

  7. Apr 2024
  8. Mar 2024
    1. for - liberalism - economic growth - adjacency - liberalism - economic growth

      Adjacency - between - growth - liberalism - adjacency statement - Since researching the work of Christopher Shaw, and especially his book - Liberalism and the Challenge of Climate Change - I can see the adjacency between liberalism and economic growth - Laws are a cap on one type of behavioral liberty, and yet, there is no cap on consumptive liberty, which is what is causing us to collectively exceed natural limits

    1. It is a specific set of social relations resulting from capitalist accumulation, which not only drive the reproduction of capitalism but act as a central stabilizing mechanism in modern society.
  9. Jan 2024
    1. the mining operations on Halmahera are now penetrating deep into the rainforest of the Hongana Manyawa.” Vast areas of rainforest on Halmahera island are due to be logged and then mined for nickel. Companies including Tesla are investing billions in Indonesia’s plan to become a major nickel producer for the electric car battery market. French, German, Indonesian and Chinese companies are involved in mining in Halmahera.
      • for: progress trap - green growth - nickel mining - evicting uncontacted tribe

      • progress trap: green growth - mining

        • Capitalist logic justifies this violence
        • We destroy the earth in order to save the earth
        • Question
          • Is this really the way we should be doing things?
          • Is the green growth agenda really going to keep humanity safe? Or will the unintended consequences, the progress trap be worse than the problem it is attempting to solve?
      • for: green growth - ethics - indigenous violence, Indonesia - violence against indigenous people, progress trap - green growth - nickel mining - eviction of indigenous people
  10. Dec 2023
    1. we have enough of these minerals in the 01:16:25 world to run a world transportation system off electricity using batteries but we don't have enough if we need batteries to stabilize our grids because we've got intermittent power from solar 01:16:39 and wind
      • for: green growth - shortage of batteries
    1. Why do some societies successfully adapt while others do not? I concluded that a central characteristic of societies that successfully adapt is their ability to produce and deliver useful ideas (or what I call “ingenuity”) to meet the demands placed on them by worsening environmental problems.
    1. normal crisis in the system for most people is degrowth like 00:22:22 most people's living standards don't rise that's so it's it's divorced from the experience that that most people have in in in the UK you know where we're where we're speaking from wages at 00:22:36 the same level they were in 2005 rents aren't bills aren't your groceries aren't but your pay is so um you know most people have been experiencing 00:22:49 degrowth that's the comms reason why it's bad
      • for: degrowth - criticism - bad communication, suggestion - growth and degrowth simultaneously

      • suggestion

        • evolution / transition / transformation are better terms as it indicates something is dying at the same time diverging is being born
        • it is highly misleading to think one dimensionally as there are many things that have to degrow and many things that have to grow simultaneously
          • degrowth of carbon emissions, which implies pragmatically in the short time scale noe available a significant degrowth of fossil fuels
        • growth of a new energy system to replace much of it
        • degrowth of unnecessary and harmful consumption accompanied
          • growth of holistic network of root level wellbeing activities and the low carbon infrastructure to support it
    2. why do we need 00:24:19 to have economic expansion because there's 300 trillion dollar of debt based on future expansion so if we don't have future expansion that's $300 trillion 00:24:33 worth of debt which isn't going to be repaid entirely which means total financial crisis and so on and so right I say it is baked into the system
      • for: adjacency - debt - growth

      • adjacency between

        • debt
        • growth
      • adjacency statement
        • in the current different of endless growth, debt requires growth to pay off the debt
        • we borrow money to open a new business and have to GROW our market shares to service the debt
        • multiplier millions and billions of times the world over, we have too brief our markets and sell more stuff too post back our loans
  11. Nov 2023
    1. Globally, 70% of today’s urban growth (PDF) occurs outside the formal planning process.
      • for: interesting fact - urban growth and slums, quote - urban growth and slums

      • interesting fact: urban growth and slums

      • quote: urban growth and slums

        • globally, 70% of today's urban growth occurs outside the formal planning process
      • comment

        • this is definitely a unique urban planning problem of large metros, especially in the Global South
    1. we're in a position as a modern techno-industrial culture this is my view that it's false to say what the oil 00:29:32 companies are saying that we can keep producing oil and gas we'll get the society to pay for carbon capture and storage and and other stuff but it's going to be a technological salvation 00:29:44 and then we can keep on with our life that's one version the the other version is the environmentalist version which the federal government has bought into and that is we'll go green and then we 00:29:57 can keep everything
      • for: false dichotomy of sustaining modernity

      • paraphrase

        • The pace of modernity can neither be sustained in a high carbon nor a low carbon green economy
        • No matter what the political party, they all subscribe to a view of sustaining the same or greater pace of modernity
      • comment

        • libertarians want no constraints
        • but nature herself imposes limits
        • populations collapse if resources are overused
        • human populations who adopt a Libertarian approach eventually encounter a limit anyways
  12. Oct 2023
    1. Acinetobacter baylyi ADP1 (30) and ADP1-ISx (11) were grown at 30°C in LB-Miller (10 g NaCl, 10 g tryptone and 5 g yeast extract per liter) or ABMS minimal medium (40)

      Reference for ADP1-ISx strain

      1. Suárez G.A., Renda B.A., Dasgupta A., Barrick J.E.. Reduced mutation rate and increased transformability of transposon-free Acinetobacter baylyi ADP1-ISx. Appl. Environ. Microbiol. 2017; 83:e01025-17. [PMC free article] [PubMed] [Google Scholar] [Ref list]
    1. Television, radio, and all the sources of amusement andinformation that surround us in our daily lives are also artificialprops. They can give us the impression that our minds are active, because we are required to react to stimuli from outside.But the power of those external stimuli to keep us going islimited. They are like drugs. We grow used to them, and wecontinuously need more and more of them. Eventually, theyhave little or no effect. Then, if we lack resources within ourselves, we cease to grow intellectually, morally, and spiritually.And when we cease to grow, we begin to die.

      One could argue that Adler and Van Doren would lump social media into the sources of amusement category.

    1. 04:00 shame as feedback and driving growth (most powerful emotion)

      • also see how anxiety can be used and leveraged for growth (as a whisper that aids, rather than destroying)
  13. Sep 2023
  14. nonprofit.ventures nonprofit.ventures
    1. Nonprofit Ventures is dedicated to supporting the Post-Growth Entrepreneurial community.

      Post Growth Entrepreneurship website

    1. better health, better security, better economy, secure job, better... Simply a more modern, attractive life.
      • for: Johan Rockstrom - wellbeing economy, wellbeing economy, green growth, degrowth, question, question - Johan Rockstrom - green growth or degrowth?
      • question
        • Does Johan Rockstrom advocate for a green economy or degrowth?
        • He would seem to be arguing for green growth as degrowth, if not done extremely carefully, can result in a drop in wellbeing.
        • How does he see this taking place when the elites perceive that they have the most (at least materially) to give up? Is there a contradiction here?
  15. Aug 2023
    1. This month's Museletter kicks off with a short response to the latest IPCC report and why we're failing to curb carbon emissions despite the dire warnings. The second article looks at recent data from China on declining population and slowing economic growth rates and why, contrary to most analysis, this may not all be bad news.

      Curbing growth and emissions

    1. there's no uh uh catastrophe even if things plug along as they're going and there's no mass die off of humans or anything like that 00:36:47 the population is set to decline i don't know when the peak is supposed to come but uh the peak is supposed to come at you know within the next 10 20 years or so 00:36:59 and after that the world population will start to decline how is how is this growth capitalism model growth-based capitalism model how is that going to 00:37:12 function when the world is shrinking
      • for: population decline, economic growth vs population decline
      • comment
        • John makes a good point
        • how will humans negotiate a growth economy when population is shrinking?
        • it may be that AI automation may lessen the need for human capacity, but the future is unknown how these forces will balance out
  16. Jul 2023
    1. one of the things I think Civil Society has to be aware of is that there's been 00:09:33 a deliberate misuse of the prospects of technology
      • for: net zero, kick the can down the road, green growth, degrowth, NET, negative emissions technology
      • Title
        • Corporations can't be greened
      • Author Erin Remblance

      • Description

        • The author argues that corporations cannot be greened.
        • In other words, by definition, they cannot put nature ahead of profit and this inherent flaw means they will never do enough, and will never transcend greenwashing
        • The real question then is this
          • Can we transition to a green capitalist economy within planetary boundaries in time to avoid planetary tipping points?
  17. Jun 2023
  18. Apr 2023
    1. Only a handful have been set up this century: University of California Merced (2005), Ave Maria University (2003) and Soka University of America (2001). Just five U.S. colleges founded in the past 50 years make it into the Times’s top 25 “Young Universities”: University of Alabama at Birmingham (founded 1969), University of Texas at Dallas (1969), George Mason (1957), University of Texas at San Antonio (1969) and Florida International (1969). Each is (or originated as) part of a state university system.

      How does he focus on the dearth of new universities, particularly in populations which have only been growing? No mention of the growing number of colleges which have gone bankrupt and disappeared? Given population growth, with appropriately commensurate funding (a political football), we should have seen a huge number of new institutions just from that.

  19. Mar 2023
    1. Fig. 3. Remaining carbon budget and millionaire emission growth, 2022–2050*.

      Graph - millionaire emission growth vs remaining carbon budget - Note the year 2037 on this graph - This is when millionaire emissions exceeds remaining carbon budget

    2. 5245 superyachts with lengths of 30–180 m in 2021, a five-fold increase from 1090 yachts in 1990

      yacht stats - 2021: 5245 superyachts of lengths 30-180m - 1990: 1090 superyachts of lengths 30-180m - stats - yachts - quote - yachts

    1. Ads, Andrew and James discuss where the the climate movement is right now, how deep time plays into the effects we are having on the planet, when good people do bad things because of poor systems and what happens next if 1.5C fails.
      • 21:52 Carbon credits, carbon markets
        • it's a scam designed to perpetuate fossil fuel use, in a phoney war against the climate crisis
        • Offsets were designed to allow polluters to pay others to create schemes that would compensate or "offset" that pollution. The classic example WAS afforestation, the planting of trees that can sequester that carbon.
        • Carbon neutrality comes from this idea that you can keep polluting if you offset it and become "carbon neutral"
        • A company may decarbonize a lot of their supply chain but may struggle to get rid of airflights around the world. In that case, they use offsets. When companies analyze the very difficult choices, they take the easy way out and use carbon offsets
        • However, there is so much offsets for afforestation now that there isn't enough land on earth
        • Carbon markets are a recipe for grifting and fraud or zero impacts
        • This is the current state of offsets

      31:00 Shell oil carbon offset greenwashing scam - the sky zero proposal - Shell claims they can offset all the O+G emissions out of the ground - it is preposterous - there's not enough land on earth when you tally up all the carbon offset afforestation schemes

      • 32:30 Neo-colonialism

        • rich white man can offset his emissions by buying land from a developing nation. Now the indigenous people cannot use that land for any reason.
        • also, will require huge amount of water to grow those trees
        • we don't have enough land and we don't have 100 years, only 5 years.
        • nature-based solutions are an industrial, myopic approach
      • 37:00 Deferred Emission Reduction

        • a lot of carbon credits are called deferred emission reduction credits.
        • this is avoided emissions - ie. trees in a forest with 100 ton of sequestering potential
        • this is promise to not destroy the biosphere any further so it's not removing any existing carbon
        • maybe multiple people might own the same forest, or someone might come along and burn it down
        • Trees are vulnerable to climate impacts - ie. Microsoft bought a large forest in California that later burned down in a climate change intensified wildfire
      • 40:00 can we do anything within the extractive capitalist system?

        • some people claim that as long as extractivist capitalism still persists, we cannot have system change
        • also a neocolonialist element - global north exploited the global south to create most of the emissions in the atmospheric commons
        • a number of people are beginning to see that an extractivist capitalist system is not in line with effectively addressing the climate crisis
        • wind, solar, etc has displaced electricity generation in a number of countries like in the UK. However, these are only a few countries.Renewables are helping increase overall energy production
      • 44:22: Stop burning fossil fuels

        • t doesn't matter if investments in renewables triple. It won't make a difference if we don't significantly stop burning fossil fuels at the same time.
      • 47:00 economic growth prevents real change

        • Insisting on 1, 2 or 3% growth, will limit the response to the climate threat to render it irrelevant
        • Climate change is still mostly an optimization problem. They are more concerned with economic damage.
        • Economists believe that anything that threatens economic growth cannot be accepted
      • 51:00 Degrowth making headway

        • Degrowth scholars are getting more attention on the need to decouple economic grwoth from climate policies
      • 52:10 Is there a positive future scenario - The role of solidarity

        • Solidarity is the greatest strength we can harness.
        • The success of Doughnut Economics gives me hope
        • The richest 1% must reign in their impacts and redistribute to allow the impoverished to live humane lives
        • We can all have good lives and we don't have to manufacture that wonder
        • This is what it is to be human
  20. Feb 2023
    1. Autobibliographie annotée (2018-2022) <br /> by Arthur Perret on 2023-02-20 (accessed:: 2023-02-24 11:30:20)

      Perret looks back at several years of blogposts and comments on his growth over the intervening years. This sort of practice and providing indicators of best posts is an interesting means of digital gardening.

    1. Categories mean determination of internal structure less flexibility, especially “in the long run“ of knowledgemanagement and storage

      The fact that Luhmann changed the structure of his zettelkasten with respect to the longer history of note taking and note accumulation allowed him several useful affordances.

      In older commonplacing and slip box methods, one would often store their notes by topic category or perhaps by project. This mean that after collection one had to do additional work of laying them out into some sort of outline to create arguments and then write them out for publication. This also meant that one was faced with the problem of multiple storage or copying out notes multiple times to file under various different subject headings.

      Luhmann overcame both of these problems by eliminating categories and placing ideas closest to their most relevant neighbor and numbering them in a branching fashion. Doing this front loads some of the thinking and outlining work which would often be done later, though it's likely easier to do when one has the fullest context of a note after they've made it when it is still freshest in their mind. It also means that each note is linked to at least one other note in the system. This helps notes from being lost and allows a simpler indexing structure whereby one only needs to use a few index entries to get close to the neighborhood of an idea as most other related ideas are likely to be nearby within a handful or more of index cards.

      Going from index to branches on the tree is relatively easy and also serves the function of reminding one of interesting prior reading and ideas as one either searches for specific notes or searches for placing future notes.

      When it comes to ultimately producing papers, one's notes already have a pre-arranged sort of outline which can then be more easily copied over for publication, though one can certainly still use other cross-links and further rearranging if one wishes.

      Older methods focused on broad accretion of materials into subject ordered piles while Luhmann's practice not only aggregated them, but slowly and assuredly grew them into more orderly trains of thought as he collected.

      Link to: The description in Technik des wissenschaftlichen Arbeitens (section 1.2 Die Kartei) at https://hypothes.is/a/-qiwyiNbEe2yPmPOIojH1g which heavily highlights all the downsides, though it doesn't frame them that way.

  21. Nov 2022
    1. locally-based staff and carries out its programs in conjunction with local partners. Teams of international instructors and volunteers support the programs through projects year-round.

      So many good features in your project!

      Employing local staff that know the setting and can be role models for the kids.

      Supporting mentoring by volunteers to scale.

      Working with bodies to get a visceral experience that change is possible.

      Mentoring in groups to build a community.

      Spotlighting diversity and building bridges beyond the local community.

      Some related resources: Ballet dancer from Kibera

      Fighting poverty and gang violence in Rio's favelas with ballet

  22. Sep 2022
    1. here are those same numbers compared 00:41:21 against reported global reserves so there's the amount of metal we need and there is the global reserves this column is the proportion of metals required to 00:41:33 phase out fossil fuels as a percentage that is of all the copper we need to make one generation of units current global reserves will get us 19.23 00:41:45 of the way there we don't have enough copper for one generation

      !- for : metals for energy transition - only have 19% of metals required for the first generation of phase out

    2. we used to have 500 years ago a small human system a big pile of natural resources and a small pollution plume 00:46:47 an industrial ecosystem of unprecedented size and complexity that took more than a century to build with support of the highest calorifically dense source of cheap energy the world has ever known that would be oil 00:46:59 in abundant quantities with easily available credit and unlimited mineral resources and now we've got a system that's a human system that's really large 00:47:10 a depleted natural resources [Music] portfolio compared to what we had but we've now got a massive pollution stream so now we seek to build an even more complex system with very expensive 00:47:24 energy a fragile finance system saturated in debt not enough minerals with an unprecedented number of human population embedded in a deteriorating environment 00:47:35 so at this point i'm going to say this is probably not going to go as planned

      !- key finding : green growth is not likely to be feasible - Simple diagram that illustrates the problem

    3. it also is summed together so everything we need is summed together per metal and that gives us this column here total metal required to produce one generation of technology units to phase 00:40:15 out fossil fuels and so that the that we've got these numbers here the next column is global metal production as it was from mining in 2019 00:40:28 so this is all from the usgs and the bgo the final column is how many years of production at the 2019 rate um would be needed to hit the actual 00:40:42 volumes needed so 2019's the last year before covert is the last year of stable data that's why i've used it so you might notice some of these numbers are rather large 00:40:55 like we will need seven thousand one hundred and one years of production to produce the needed number of volume of vanadium that's your uh your redox batteries

      !- for : metals for energy transition - unfeasible numbers

    4. the idea that we're going to do this in seven or eight years is very amusing so then the question is oh we'll just open more mines it's simple right

      !- for : metals for energy transition - not feasible

    5. let's put the electrical power systems together these electrical power 00:22:29 systems that this is actually on the low side because most industrial action happens with the consumption of coal and gas on site and then it's converted to energy on site this is what's just been drawn off the power grid 00:22:42 so there's a vast amount of energy associated with manufacturing that is not included here and that is actually a huge piece of work to include that so these numbers i'm showing you are very much on the low side 00:22:55 so we're going to put it all together we need 36 000 terawatt hours all there abouts that's a that's a very low estimate

      !- key insight : minimum power of energy transition, excluding the large amount of energy for industrial processes ! - for : energy transition, degrowth, green growth

    6. current plans are not large enough in scope the task before us is much larger than the current paradigm allows for

      !- key insight : not enough mineral capacity to buildout replacement green growth, renewable energy system !- for : degrowth vs green growth

    7. assessment of extra capacity required of alternative energy electrical power systems to completely replace fossil fuels

      Title: Assessment of extra capacity required of alternative energy electrical power systems to completely replace fossil fuels Author: Prof. Simon Michaux, Geological Survey of Finland (GTK) Year: 2022

  23. Aug 2022
    1. If you’re VC funded, then you “need” to spend the money you raised in 18–24 months, and grow 3–5X in that time, which means a base rate of 10+% MoM
    1. Successful SaaS startups grow their MRR at a rate between 10% and 25% monthly growth rate (MoM). You can use these benchmarks as sanity checks for your model but don’t use these numbers to project your growth
    1. John Burn-Murdoch. (2021, November 25). Five quick tweets on the new variant B.1.1.529 Caveat first: Data here is very preliminary, so everything could change. Nonetheless, better safe than sorry. 1) Based on the data we have, this variant is out-competing others far faster than Beta and even Delta did 🚩🚩 https://t.co/R2Ac4e4N6s [Tweet]. @jburnmurdoch. https://twitter.com/jburnmurdoch/status/1463956686075580421

    1. freelyextendableor changeableatanypoint;so thatthewaywillalwaysbeclearforgrowth,onanymatter.

      clear for growth on any matter

    Tags

    Annotators

  24. Jul 2022
    1. The debate might seem too trivial to care about, but as authors Simon Lewis and Mark A. Maslin demonstrate, the stakes are very high indeed. They show that scientists since the 18th century have recognized human influence on the face of the earth. What we have learned since then, and especially in the past 50 years, shows our influence has grown only greater; we just don’t want to admit it, because then we’d have to try to clean up the mess we’ve made.

      Ever since Limits to Growth was released, incumbent power has been in a continuous state of denial.

  25. Jun 2022
    1. Numerous studies have shown thatthe fiscal state’s rise in power made a major contribution to the pro-cess of economic development. The new receipts did in fact make itpossible to finance expenditures that proved indispensable not onlyfor reducing inequalities but also for encouraging growth. These ex-penditures included a massive and relatively egalitarian investmentin education and health care (or, at least, a much more massive andegalitarian investment than any previous); expansion of transporta-tion and other community infrastructure; the replacement income,such as retirement pensions, necessary for supporting an aging popu-lation; and reserves, such as unemployment insurance, for stabilizingthe economy and society in the event of a recession.1

      See especially P. Lindert, Growing Public: Social Spending and Economic Growth since the Eighteenth Century (Cambridge: Cambridge University Press, 2004).

      Ample evidence has shown that increasing taxes in Western countries along with the states' power to use it during the majority of the 1900s not only reduced inequalities but encouraged growth.

    Tags

    Annotators

    1. In contrast to the unhelpful but common argument about whether ‘the problem’ is population growth or consumption, it is not novel to argue that the problem is both—plus waste. Because of ongoing need for progress on all three, this point of intervention is nonetheless key. Unlike research on impact as a function of population, affluence and technology (1 = PAT), we point to strong opportunities to decouple affluence from material consumption [leverage point 1]. We also side with those who argue that more efficient production is insufficient, and that volumes of production and consumption are key variables

      All three variables - population growth, consumption and waste must be minimized simultaneously in order to bend the curve back to a safe operating safe for humanity

  26. Apr 2022
    1. ReconfigBehSci. (2022, January 23). RT @LauraMiers: BA.2’s growth advantage over BA.1 is jarring. Meanwhile, we are operating under the assumption that “Omicron will end the p… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1485519516914302980

  27. Mar 2022
  28. Feb 2022
    1. Cornelius Roemer. (2022, February 12). Fantastic work by @UKHSA comparing serial intervals of BA.1, BA.2 and Delta as published in the most recent technical briefing. BA.2 seems to have even shorter serial interval than BA.1 This could help explain different relative growth rates of BA.2 vs BA.1 in different countries https://t.co/Gch94Ew8CX [Tweet]. @CorneliusRoemer. https://twitter.com/CorneliusRoemer/status/1492434232664375304

    1. Dweck shows convincingly thatthe most reliable predictor for long-term success is having a “growthmindset.” To actively seek and welcome feedback, be it positive ornegative, is one of the most important factors for success (andhappiness) in the long run. Conversely, nothing is a bigger hindranceto personal growth than having a “fixed mindset.” Those who fearand avoid feedback because it might damage their cherishedpositive self-image might feel better in the short term, but will quicklyfall behind in actual performance (Dweck 2006; 2013).

      Carol Dweck shows that the most reliable predictor for long-term success is what she calls having a "growth mindset" or the ability to take feedback and change.


      This seems related to the idea of endergonic reactions and the growth of complexity as well as the idea of the meaning of life.

      What do these systems all have in common? What are their differences? What abstractions can we make from them?

      Relate this to https://hypothes.is/a/pdWppIX5EeyhR0NR19OjCQ

    1. Trevor Bedford. (2022, January 28). Omicron viruses can be divided into two major groups, referred to as PANGO lineages BA.1 and BA.2 or @nextstrain clades 21K and 21L. The vast majority of globally sequenced Omicron have been 21K (~630k) compared a small minority of 21L (~18k), but 21L is gaining ground. 1/15 [Tweet]. @trvrb. https://twitter.com/trvrb/status/1487105396879679488

    1. In crowded housing markets in large cities, house flipping is often viewed as a driver of inequality.

      If house flipping is viewed as a driver of inequality in crowded housing markets in larger cities, what spurs it on? What do the economics look like and how can the trend be combatted?

      What effect does economic speculation have?

    2. So to attract newcomers, towns have attempted a dizzying array of stunts and initiatives.

      Have they considered consolidation? Abandon three or four cities to aggregate into one?

    3. “When I moved to Kansas,” Roberts said, “I was like, ‘holy shit, they’re giving stuff away.’”

      This sounds great, but what are the "costs" on the other side? How does one balance out the economics of this sort of housing situation versus amenities supplied by a community in terms of culture, health, health care, interaction, etc.? Is there a maximum on a curve to be found here? Certainly in some places one is going to overpay for this basket of goods (perhaps San Francisco?) where in others one may underpay. Does it have anything to do with the lifecycle of cities and their governments? If so, how much?

  29. Jan 2022
  30. Dec 2021
    1. Elsewhere, I have critiqued this ideology on the grounds that there are other stakeholders besides shareholders who, through the provision of capital or labor, make contributions to the business enterprise that help to generate future returns but without a guaranteed share of these returns.101 Through government investments and subsidies, taxpayers regularly pro-vide finance to companies without a guaranteed return. As risk bearers, therefore, taxpayers have a claim on corporate profits if and when they are generated. In addition, through the exercise of skill and effort beyond those levels required to lay claim to their current pay, workers regularly make productive contributions to the companies for which they work without a guaranteed return, but with an expectation of future profits in the forms of higher wages and benefits, more secure employment, and better work conditions. Confronting agency theory with what I call “in-novation theory,” I argue that sharing corporate profits with these other risk-bearers (taxpayers and workers) is essential not only for equitable distribution, but also for sustainable productivity gains that make higher standards of living possible.1

      william lazonick's 'innovation theory', an alternative to 'agency theory'/MSV which argues that if the logic justifying shareholder's rights to profits (they take on risk) is true, workers and taxpayers also have a right to profits

    2. employment generated by ongo-ing government spending, particularly on higher education, healthcare, advanced technology, and physical infrastructure (for example, the inter-state highway system), complemented the employment opportunities provided by the business sector.

      infrastructure and the resulting economic gains can only happen once

    1. In her book Meaning in Life and Why it Matters (2010), the US philosopher Susan Wolf has argued, against Taylor, that even if Sisyphus is feeling fulfilled, owing to the nature of the activity in which he is engaged, his feeling fulfilled is not reasonable. She argues that the object of an agent’s feeling of fulfilment is represented in the mind of the agent as being something that is objectively good. In the case of Sisyphus, even if he is fulfilled, he misrepresents the source of his fulfilment as good. So Wolf argues that the meaningfulness of an activity or goal is a function not only of one’s being fulfilled in engaging in it/pursuing it, but the feeling of fulfilment also needs to be a fitting response to the activity or goal. And it is only a fitting response if the activity or goal is objectively pursuit-worthy. What would render an activity or goal objectively pursuit-worthy? Objective pursuit-worthiness is in part owing to the value of the end or activity coming from outside of oneself. Wolf admits that determining objective pursuit-worthiness is not easy, and involves a process of discovery. A possibility not explicitly endorsed by Wolf (but not rejected by her, either) is that an activity or goal is objectively pursuit-worthy if engaging in that activity is conducive to the cultivation of virtues. My suggestion is that, so long as an activity is generally conducive to developing character traits and intellectual traits that will enhance and not impede the flourishing of both an agent and those with whom they interact, it is objectively pursuit-worthy.

      Intellectual and character growth holistically, in a positive manner. That is the objective worthiness of any task. These goals, must be outlined in any activity undertaken, and their worth must be scaled according to our own standards. Because time is limited, it serves us well to maximise the objective worthiness that we extract from any task/activity/job/career. Thus time frames must also be defined. A multifaceted growth mindset requires a constant reexamination of all these aspect- i.e.- objective worthiness and time frame. An unexamined life is not worth living, and this shall be applied ona daily basis. One must recognise where they lose time, fill those holes, and proceed to extract some meaning from it.

  31. Nov 2021
    1. When they do that, they are whole because Anchored Self living is holistic living… paradoxes are resolved and the shadow is embraced, forgiven, and transmuted.

      Resolve my paradoxes, embrace my shadow...forgiveness and transmutation.

    1. Prof. Christina Pagel. (2021, November 3). Good @NatGeo article by @Ecquis on the growing AY.4.2 variant in the UK with lots of great experts explaining it. And a little bit of me too! At its current growth rate, it will probably become dominant in UK by the end of the year. Https://t.co/X9O9kbew2L [Tweet]. @chrischirp. https://twitter.com/chrischirp/status/1455899379475361795

  32. Oct 2021
    1. Over the course of this super link-laden journey, we’d consider the alarmingly hypocritical possibility that it’s been overlooked by mainstream conversations only because it has so long operated in the precise manner we claim is so hopelessly absent from its neighbors in its deliberate, principled, and innovative journey towards a transparent, progressive vision.

      In retrospect, the dynamic I'm addressing here is bascially My Whole Shit. That is - one of (if not the) primary forces that have compelled The Psalms.

  33. Sep 2021
    1. c. 19, s. 700

      Jobs, Growth and Long-term Prosperity Act, SC 2012, c 19, s. 700:

      • removed the previous s. 2(2)
      • replaced it with: "(2) Unless otherwise indicated, references in this Act to “this Act” include regulations made under it and instructions given under subsection 14.1(1)."
    1. Since about 70% of water delivered from the Colorado River goes to growing crops, not to people in cities, the next step will likely be to demand large-scale reductions for farmers and ranchers across millions of acres of land, forcing wrenching choices about which crops to grow and for whom — an omen that many of America’s food-generating regions might ultimately have to shift someplace else as the climate warms.

      Deep Concept: The US Government, in the 1960's/70's provided a crystal ball glimpse into the future by defining climate change (man-made global warming) as a national security concern. Various reports warned of "exponential" growth (population) and related man-made factors (technology etc.) that would contribute to climate change and specifically discussed the possibility of irreconcilable damage to "finite" natural resources.

  34. Aug 2021
    1. A baby grows to adult size, after which growth goes to maintaining stability, homeostasis, balance. Growth much beyond that leads to obesity. For a baby to grow endlessly bigger would be first monstrous, then fatal.

      Growth has a limit dependent on the nature of the system

    1. According to Brian Balfour, "The fastest growing products are better represented as a system of loops, not funnels. Loops are closed systems where the inputs through some process generates more of an output that can be reinvested in the input. There are growth loops that serve different value creation including new users, returning users, defensibility, or efficiency."

      Treat product growth as loops not funnels.

  35. Jul 2021
  36. Jun 2021
    1. Bolze, A., Cirulli, E. T., Luo, S., White, S., Cassens, T., Jacobs, S., Nguyen, J., Ramirez, J. M., Sandoval, E., Wang, X., Wong, D., Becker, D., Laurent, M., Lu, J. T., Isaksson, M., Washington, N. L., & Lee, W. (2021). Rapid displacement of SARS-CoV-2 variant B.1.1.7 by B.1.617.2 and P.1 in the United States [Preprint]. Infectious Diseases (except HIV/AIDS). https://doi.org/10.1101/2021.06.20.21259195

  37. May 2021
  38. Apr 2021
  39. Mar 2021
  40. Feb 2021
    1. So which seems likelier: that we're no better off than we were a quarter century ago, or that Shadow Stats is total bunk?

      Great Question

      This is an easy question to answer from my perspective. For me (age 62) and most of my peers, their kids and their peers, we are NO better off than we were a quarter century ago! A large part is the change from Industrial/Manufacturing to Technology and the outsourced labor and manufacturing. America has changed, this is FACT

    1. A second trap is thinking that you just need to work on yourself in order to grow your career. For example, "To progress, I just need to get better at [insert skill.]" But you are only one part of the equation.There is a whole other part of the equation, which is your environment. Your environment either limits or amplifies your own ability to get better at a skill.
      • Trap: "I just need to work on myself more"
      • Assumption: You need to focus on improving X
      • Impact: You need to consider the environment. if you don't, you could end up in a place that limits your ability to work on that skill instead of amplify it.
    2. "Should I leave my current role?""How do I compare or choose between two or more opportunities?""What is preventing me from moving forward?"
      • do we switch projects?
      • teams?
      • career paths?
      • what projects do we take on, vs not, and why?
    1. Il s’agit en fait plu­tôt d’une inca­pa­ci­té de pen­ser vrai­ment avec cette pos­si­bi­li­té que quelque chose vienne enrayer la nor­ma­li­té des choses, la rou­tine de la crois­sance…
  41. Jan 2021
    1. “Different from natural science and social science, Dataology and Data Science takes data in cyberspace as its research object. It is a new science.”

      Computer engineering and coding has been rapidly growing at this point and the internet is becoming more available to everyone which helps keep the innovation driving and is a large reason in the expansion of data science.

    1. Long before there was the Internet, there was the commonplace book — a creative and intellectual ledger of fragmentary inspirations, which a writer would collect from other books and copy into a notebook, often alongside his or her reflections and riffs. These borrowed ideas are in dialogue with the writer’s own imagination and foment it into original thinking. Over long enough a period of time — years, decades, often a lifetime — the commonplace book, while composed primarily of copied passages, comes to radiate the singular sensibility of its keeper: beliefs are refined, ideas incubated, intellectual fixations fleshed out, and the outlines of a personhood revealed. (Brain Pickings is, in an unshakable sense, a commonplace book.)
  42. Dec 2020
  43. Nov 2020
    1. V. natriegens grows rapidly in BHIN complex medium with a μ of up to 4.43 h−1 (doubling time of 9.4 min) as well as in minimal medium supplemented with various industrially relevant substrates.
  44. Oct 2020
    1. ​Institutions that were primarily online before the pandemic are also doing well. At colleges where more than 90 percent of students took courses solely online pre-pandemic, enrollments are growing for both undergraduate (6.8 percent) and graduate students (7.2 percent).
    1. Learning & Development Best Practices from the Top Silicon Valley Companies

      Interesting read about what top tech companies are doing to promote a growth mindset within their company. From Google to Amazon each company has a different approach that is working for them.

      7/10

  45. Aug 2020
    1. moving from emissions to concentrations in the context of forecasting long-term economic growth, the likelihood that CO2 concentrations will exceed those assumed in RCP8.5 by 2100 is at least 35%

      This means that the CO2 emissions caused by use of fossile fuels should be understood as a component of all emissions caused by continued economic growth.

    1. Altig, D., Baker, S. R., Barrero, J. M., Bloom, N., Bunn, P., Chen, S., Davis, S. J., Leather, J., Meyer, B. H., Mihaylov, E., Mizen, P., Parker, N. B., Renault, T., Smietanka, P., & Thwaites, G. (2020). Economic Uncertainty Before and During the COVID-19 Pandemic (Working Paper No. 27418; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w27418

    1. Dave, D. M., Friedson, A. I., Matsuzawa, K., Sabia, J. J., & Safford, S. (2020). Were Urban Cowboys Enough to Control COVID-19? Local Shelter-in-Place Orders and Coronavirus Case Growth (Working Paper No. 27229; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w27229

  46. Jul 2020
  47. Jun 2020
  48. May 2020
  49. Apr 2020
    1. Chronic wounds, in general, behave differently in relation to bacterial growth when compared to acute wounds. Chronic wounds develop bacterial growth that is resistant to invasion by antibiotics and is protected from the host immune defenses.
    2. Disappointingly, a recent meta-analysis failed to demonstrate any value for autologous platelet-rich plasma in the treatment of chronic wounds
    3. This approach allows treatment with patient-specific factors at an apparently physiologic ratio of growth factor concentrations.
    4. Autologous growth factors are harvested from the patient’s own platelets, yielding an unpredictable combination and concentration of factors, which are then applied to the wound.
    5. Fibroblasts stimulated by growth factors can produce type I collagen and glycosaminoglycans (e.g., chondroitin sulfates), which adhere to the wound surface to permit epithelial cell migration, as well as adhesive ligands (e.g., the matrix protein fibronectin), which promote cell adhesion.
  50. Dec 2019
    1. “death phase,” where at least 99% of the cells in the culture lose viability

      So the 'death' in death phase is only loss of viability?

      I thought the cells lyse and are eaten up by neighbours; while reducing the OD (due to cell lysis)

  51. Nov 2019
    1. An emotional intelligence course initiated by Google became a tool to improve mindfulness, productivity, and emotional IQ. The course has since expanded into other businesses which report that employees are coping better with stressors and challenges. Rating: 7/10 Key questions...what is the format of the course, tools etc?

  52. Oct 2019
    1. Cengage’s own research forecast that the use of OER as primary courseware was poised to triple within five years.

      Useful info, which I'm not above using.

  53. Jul 2019
    1. Given a dataset of transactions, the first step of FP-growth is to calculate item frequencies and identify frequent items. Different from Apriori-like algorithms designed for the same purpose, the second step of FP-growth uses a suffix tree (FP-tree) structure to encode transactions without generating candidate sets explicitly, which are usually expensive to generate. After the second step, the frequent itemsets can be extracted from the FP-tree.
    1. The state’s population grew by 14.4 percent over the past eight years, faster than any other state, according to Census Bureau population estimates. And that’s increasingly because of migration, which contributed 43 percent to the state’s population growth between 2015 and 2018, compared to 16 percent in the previous four-year period

      Utah's highest population growth across the nation is one factor that contributes to housing shortage. The drastic increase in migration over the past 4 years indicates there is a great chance that this trend will continue which can worsen the current housing crisis in Utah.

  54. Apr 2019
    1. Personality development, if done right, inevitably sets us on a collision course with the unjust world in which we live, and with everything that is primitive, unevolved and destructive within ourselves.  One of the major developmental dynamisms—i.e, the internal forces guiding our individual growth as described in TPD—is positive maladjustment: a lack of adjustment to the world as is, guided by our vision of what ought to be which turns us into eternal misfits, “guests of reality,” to use the title of Par Lagerkvist’s story. Positive maladjustment is always rooted in universal human values embedded in our conscience and gives rise to our protest, internal and external, against the inhumane status quo. Sometimes this protest can take a form of non-cooperation or silence, or even mental illness, but it is still positive and expressive of better mental health than unreflective adjustment to what is. Jiddu Krishnamurti reminded us that “[i]t is no measure of health to be well adjusted to a profoundly sick society.”  This maladjustment in turn awakens other developmental dynamisms such as guilt, shame, astonishment with oneself, disquietude with oneself, subject-object in oneself, and others that create the basis for transcending our biological and social limitations through personality growth.
    2. His clinical experience led him to develop the theory of positive disintegration (TPD), which posits that, far from being destructive and undesirable, many forms of psychological suffering—anxiety, depression, doubts, inner conflicts, even psychosis—are positive and necessary for emotional and personality development. More often than not, they are expressive of the emerging understanding of the multilevel nature of reality, inner and external, and, related, an objectively existing hierarchy of human values. This understanding becomes a basis of personality growth through positive disintegration
    1. “The primary goal of our recommendation systems today is to create a trusted and positive experience for our users,” the document reads. “The YouTube company-wide goal is framed not just as ‘Growth’, but as ‘Responsible Growth.’”
    1. Klotho-deficient mice have accelerated aging phenotypes, whereas overexpression of Klotho in mice extends lifespan. Klotho is an anti-aging single-pass membrane protein predominantly produced in the kidney, with shedding of the amino-terminal extracellular domain into the systemic circulation. Circulating levels of soluble Klotho decrease with age, and the klotho gene is associated with increased risk of age-related diseases. The three forms of Klotho protein have distinct functions. Membrane Klotho forms a complex with fibroblast growth factor (FGF) receptors, functions as an obligatory co-receptor for FGF23, which is involved in aging and the development of chronic diseases via regulation of Pi and vitamin D metabolism. Secreted Klotho functions as a humoral factor with pleiotropic activities including regulation of oxidative stress, growth factor signaling, and ion homeostasis. Secreted Klotho is also involved in organ protection. The intracellular form of Klotho suppresses inflammation-mediated cellular senescence and mineral metabolism. Herein we provide a brief overview of the structure and function and recent research about Klotho.
  55. Feb 2019
    1. Work with what you have, to support the people around you and together you'll create a community that has a defined shape and form only in hindsight. Instead of worrying about having enough onboarding ramps, I say we make a future space that is so exciting, so fun, that is such a cool party with lights so bright that everyone wants to build their own methods to get here and join in. And I thought: what's the coolest, most party thing in the world? Reading.
    1. The summation of human experience is being expanded at a prodigious rate

      The prodigious rate itself is expanding, is it a scale even conceivable at this time? (insert the usual stats of YouTube content growing at 300 hours a minute).

      I'm anxious to read if he anticipates the notion of turning to automation to try and handle this organization- it always seemed that Bush's vision was human focused.

  56. Jan 2019
    1. This central focus meant that the arcs were perpetually shifting position and overlapping one another. Such shifting is what Ramus hated the most: "For arts ought to consist of subjects that are constant, perpetual, and unchanging, and they should consider only those concepts which Plato says are archetypal and eternal" (99).

      Although uniformity within a discipline can be beneficial, "shifting" and "overlapping" combat stagnation. Without this constant movement, would disciplines be able to grow and develop?

  57. Nov 2018
    1. Hospitalists need to continue to take C-suite positions at hospitals and policy roles at think tanks and governmental agencies. They need to continue to master technology, clinical care, and the ever-growing importance of where those two intersect. Most of all, the field can’t get lazy. Otherwise, the “better mousetrap” of HM might one day be replaced by the next group of physicians willing to work harder to implement their great idea. “If we continue to be the vanguard of innovation, the vanguard of making the system work better than it ever has before,” Dr. Wachter says, “the field that creates new models of care, that integrates technology in new ways, and that has this can-do attitude and optimism, then the sky is the limit.”
    2. At a time of once-in-a-generation reform to healthcare in this country, the leaders of HM can’t afford to rest on their laurels, says Dr. Goldman. Three years ago, he wrote a paper for the Journal of Hospital Medicine titled “An Intellectual Agenda for Hospitalists.” In short, Dr. Goldman would like to see hospitalists move more into advancing science themselves rather than implementing the scientific discoveries of others. He cautions anyone against taking that as criticism of the field. “If hospitalists are going to be the people who implement what other people have found, they run the risk of being the ones who make sure everybody gets perioperative beta-blockers even if they don’t really work,” he says. “If you want to take it to the illogical extreme, you could have people who were experts in how most efficiently to do bloodletting. “The future for hospitalists, if they’re going to get to the next level—I think they can and will—is that they have to be in the discovery zone as well as the implementation zone.” Dr. Wachter says it’s about staying ahead of the curve. For 20 years, the field has been on the cutting edge of how hospitals treat patients. To grow even more, it will be crucial to keep that focus.

      Hospitalists can learn these skills through residency and fellowship training. In addition, through mentorship models that create evergrowing

    3. 2003 amid the push for quality and safety. And while the specialty’s early adoption of those initiatives clearly was a major reason for the exponential growth of hospitalists, Dr. Gorman doesn’t want people to forget that the cost of care was what motivated community facilities.