35 Matching Annotations
  1. Sep 2024
    1. functional assays

      Chemiluminescence assays (measuring binding capacity)

      VWF-collagen binding assay (CBA)

      Electrophoresis (Western blot)

      Bidirectional direct sequencing of PCR products

      Paternity test

      PCR and restriction assays to detect SNVs

      in vitro expression of recombinant WT and p.P1127S VWF variants in HEK293 cells

      Platelet aggregation studies

      DDAVP test

      Binding assays

      Proteolysis assays

      in silico modeling

  2. Oct 2023
    1. Desire for an idea is like bait.When you’re fishing, you have to havepatience. You bait your hook, and then you wait.The desire is thebait that pulls those fish in—those ideas.The beautiful thing is that when you catch one fish that you love,even if it’s a little fish—a fragment of an idea—that fish will draw inother fish, and they’ll hook onto it.Then you’re on your way. Soonthere are more and more and more fragments, and the whole thingemerges. But it starts with desire.
    2. You fall in love with the first idea, that little tiny piece. And onceyou’ve got it, the rest will come in time.

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  3. Mar 2023
  4. Feb 2023
    1. Categories mean determination of internal structure less flexibility, especially “in the long run“ of knowledgemanagement and storage

      The fact that Luhmann changed the structure of his zettelkasten with respect to the longer history of note taking and note accumulation allowed him several useful affordances.

      In older commonplacing and slip box methods, one would often store their notes by topic category or perhaps by project. This mean that after collection one had to do additional work of laying them out into some sort of outline to create arguments and then write them out for publication. This also meant that one was faced with the problem of multiple storage or copying out notes multiple times to file under various different subject headings.

      Luhmann overcame both of these problems by eliminating categories and placing ideas closest to their most relevant neighbor and numbering them in a branching fashion. Doing this front loads some of the thinking and outlining work which would often be done later, though it's likely easier to do when one has the fullest context of a note after they've made it when it is still freshest in their mind. It also means that each note is linked to at least one other note in the system. This helps notes from being lost and allows a simpler indexing structure whereby one only needs to use a few index entries to get close to the neighborhood of an idea as most other related ideas are likely to be nearby within a handful or more of index cards.

      Going from index to branches on the tree is relatively easy and also serves the function of reminding one of interesting prior reading and ideas as one either searches for specific notes or searches for placing future notes.

      When it comes to ultimately producing papers, one's notes already have a pre-arranged sort of outline which can then be more easily copied over for publication, though one can certainly still use other cross-links and further rearranging if one wishes.

      Older methods focused on broad accretion of materials into subject ordered piles while Luhmann's practice not only aggregated them, but slowly and assuredly grew them into more orderly trains of thought as he collected.

      Link to: The description in Technik des wissenschaftlichen Arbeitens (section 1.2 Die Kartei) at https://hypothes.is/a/-qiwyiNbEe2yPmPOIojH1g which heavily highlights all the downsides, though it doesn't frame them that way.

  5. Aug 2022
    1. limitintegerThe maximum number of items to return. Default: 20. Minimum: 1. Maximum: 50.>= 0<= 50Default value:20Example value:10

      I find it hilariously telling that Spotify's official, very-credentialed own Web API will not retrieve more than 50 fucking tracks from a playlist lmao.

      (I lied to you just then. I find it makes me want to commit systematic acts of violence on myself.) - WTF

  6. Jul 2022
  7. bafybeibbaxootewsjtggkv7vpuu5yluatzsk6l7x5yzmko6rivxzh6qna4.ipfs.dweb.link bafybeibbaxootewsjtggkv7vpuu5yluatzsk6l7x5yzmko6rivxzh6qna4.ipfs.dweb.link
    1. coordination can be defined as the arrangement of actions across people,places and times so as maximize synergy and minimize friction. In earlier work (Heylighen, 2012b),we have analyzed coordination into four components: alignment, division of labor, workflow andaggregation.

      Definition: Coordination is the arrangement of actions across people, places and times so as maximize synergy and minimize friction. It can be analyzed into four components: 1. Alignment 2. Division of Labor 3. Workflow 4. Aggregation

  8. Aug 2021
  9. Jun 2021
  10. Apr 2021
    1. This post articulates a lot of what I've been thinking about for the past 18 months or so, but it adds the additional concept of community integration.

      Interestingly, this aligns with the early, tentative ideas around what the future of In Beta might look like as a learning community, rather than a repository of content.

  11. Mar 2021
  12. Oct 2020
    1. A more active stance by librarians, journalists, educators, and others who convey truth-seeking habits is essential.

      In some sense these people can also be viewed as aggregators and curators of sorts. How can their work be aggregated and be used to compete with the poor algorithms of social media?

    1. One thing that using this tool has highlighted for me is that there are a lot of things happening in our community every day, between news, announcements, events and other stuff. If you only rely on what your social media service of choice has decided is worth knowing because it’s generating clicks or discussion, you’re likely to miss something important. Also, do you really want to get your news crammed in between cat videos and political rants from distant acquaintances?
  13. Sep 2020
    1. Bavadekar, Shailesh, Andrew Dai, John Davis, Damien Desfontaines, Ilya Eckstein, Katie Everett, Alex Fabrikant, et al. ‘Google COVID-19 Search Trends Symptoms Dataset: Anonymization Process Description (Version 1.0)’. ArXiv:2009.01265 [Cs], 2 September 2020. http://arxiv.org/abs/2009.01265.

  14. Aug 2020
  15. Jul 2020
  16. Jun 2020
  17. Apr 2020
  18. Jul 2019
    1. Every time your child opens the email, that person knows generally where they are (or specifically, if they have other info to triangulate against).
  19. Feb 2019
  20. Jan 2019
    1. If one object is part of another object, then we use a diamond at the start of the arrow (next to the containing object), and a normal arrow at the end.

      Another way of thinking of this is, if the original owner (source) object and the owned (target) object share the same life cycle -- that is, the owned exists only when the owner does -- we say that the owner aggregates owned object(s). They share a whole-part relationship.

      What I did like very much about the video, was when the instructor pointed out that there's a small fallacy: aggregation, in OOD, does not really imply that owned object(s) must be a list.

  21. Jun 2018
    1. there have always been far more users/consumers than suppliers, which means that in a world where transactions are costly owning the supplier relationship provides significantly more leverage.
    2. The value chain for any given consumer market is divided into three parts: suppliers, distributors, and consumers/users. The best way to make outsize profits in any of these markets is to either gain a horizontal monopoly in one of the three parts or to integrate two of the parts such that you have a competitive advantage in delivering a vertical solution. In the pre-Internet era the latter depended on controlling distribution.
  22. Nov 2017
    1. And that, in fact, is a pretty good description of the IMS standard in development called Caliper, which is why I am so interested in it. In my recent post about walled gardens from the series that Jonathan mentions in his own post, I tried to spell out how Caliper could enable either a better LMS, a better world without an LMS, or both simultaneously.
    2. Stephen Downes built gRSShopper ages ago
    3. Jim Groom's ds106 uses a WordPress-based aggregation system, the current generation of which was built by Alan Levine
    4. Jim Groom's ds106 uses a WordPress-based aggregation system
  23. Aug 2015
    1. Quality (DRG) 1.2675 0.61

      It seems there is no statistically significant differences in the Quality measured between the two aggregation levels.

    2. Hospital quality and, in some cases, its relationship with effi-ciency differs depending on aggregations.

      They are talking about diagnosis (procedures) //activity// aggregation.

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