Autoantibodies (AABs) have been identified in advanced Covid, laboratory models of Covid-19 utilizing S-protein fragments. The concept that addressing the AABs is a therapeutic target is reasonable, but falls short of addressing the host-targets, the ubiquitous and critical neuroreceptors that have been rendered dysfunctional by these AABs. The a7 nicotinic acetylcholine receptors (a7Rs) rendered dysfunctional are no longer capable of stabilizing the cholinergic anti-inflammatory pathway. In our clinical experience, supported with laboratory collaborations, re-establishing a7R function plays a significant role in both acute COVID-19 as well as Post-Acute Sequelae of Covid. Focusing on therapeutics for Abs 1 or Abs2 appears to be just as short-sighted for PASC as it was for using Monoclonal Abs, IL-6 inhibitors, antivirals for acute COVID-19. The focus should be entirely on the host - targets, the a7Rs and enabling the host's CAP. Ref: doi: 10.1016/biocel.2024.106519

Anthes, E. (2021, August 19). What to Know About Boosters if You Got the Johnson & Johnson Vaccine. The New York Times. https://www.nytimes.com/2021/08/19/health/coronavirus-johnson-vaccine-booster.html

Feldman, J. (2021, September 25). All the Ways That “1 in 5,000 per Day” Breakthrough Infection Stat Is Nonsense. Slate. https://slate.com/technology/2021/09/breakthrough-infections-one-in-five-thousand-nonsense.html

Kinderimpfstoff gegen Corona: Stiko-Chef Mertens würde eigene Kinder jetzt nicht impfen lassen. (2021, December 2). FAZ.NET. https://www.faz.net/aktuell/politik/inland/stiko-chef-mertens-wuerde-eigene-kinder-nicht-gegen-corona-impfen-17662194.html

Jones, B., Wardman, L., & Tinkler, L. (2021, September 3). Coronavirus vaccine hesitancy in younger adults—Office for National Statistics. https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/healthandwellbeing/articles/coronavirusvaccinehesitancyinyoungeradults/june2021

Hawthorn, A. (2021, September 26). Like polio, the long-term impact of COVID will be measured in disability | CBC News. CBC. https://www.cbc.ca/news/canada/newfoundland-labrador/apocalypse-then-disability-1.6187990

Sample, I. (2022, January 25). Long Covid: Doctors find ‘antibody signature’ for patients most at risk. The Guardian. https://www.theguardian.com/society/2022/jan/25/doctors-find-antibody-signature-long-covid

Huang, L., & Cao, B. (2021). Post-acute conditions of patients with COVID-19 not requiring hospital admission. The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(21)00225-5

Koerth, M. (2021, November 3). The Science You Need To Make Your COVID-19 Decisions. FiveThirtyEight. https://projects.fivethirtyeight.com/covid-19-updates/

Caspersen, I. H., Magnus, P., & Trogstad, L. (2021). Excess risk and clusters of symptoms after COVID-19 in a large Norwegian cohort (p. 2021.10.15.21265038). https://doi.org/10.1101/2021.10.15.21265038

Kirby, B. J. (2022, February 9). UK is ‘past the point’ where vaccinating young children against Covid would help. https://www.standard.co.uk/news/uk/england-children-bbc-radio-europe-pfizer-b981546.html

Marsh, S. (2021, December 1). Severe Covid infection doubles chances of dying in following year, study finds. The Guardian. https://www.theguardian.com/world/2021/dec/01/severe-covid-infection-doubles-chances-of-dying-in-following-year-study

Five biggest myths about the COVID-19 vaccines, debunked. (n.d.). Fortune. Retrieved April 29, 2022, from https://fortune.com/2021/10/02/five-biggest-myths-covid-19-vaccines/

Dr Nisreen Alwan 🌻 [@Dr2NisreenAlwan]. (2021, November 4). Where is the money for ventilation in schools? Well said @GeorgeMonbiot https://t.co/DjG9Rntz0x [Tweet]. Twitter. https://twitter.com/Dr2NisreenAlwan/status/1456174302001258497

Imperial News. ‘“Issue of Inequalities” for Long COVID Patients Needs to Be Addressed | Imperial News | Imperial College London’. Accessed 22 April 2022. https://www.imperial.ac.uk/news/232234/issue-inequalities-long-covid-patients-needs/.

indie_SAGE. (2021, November 26). Indie_SAGE 26.11.21. https://www.youtube.com/watch?v=_2qSZksPdeM

BBC Radio 4—Woman’s Hour, Helena Merriman, Bus driver Tracey Scholes, Pardons for women tried as witches. (n.d.). BBC. Retrieved April 20, 2022, from https://www.bbc.co.uk/programmes/m00138g0

Nick Brown [@sTeamTraen]. (2022, January 7). RT with a better screenshot. Https://t.co/kYVXpmAC3t [Tweet]. Twitter. https://twitter.com/sTeamTraen/status/1479417464157093888

ReconfigBehSci. (2022, January 28). RT @chrischirp: BA.2 & BA.1.1 (Omicron variants) are growing in many countries. Quite what this means in terms of cases, hospitalisation… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1487066966363934720

Dr Greg Kelly. (2021, July 5). #COVID19 & kids “Doctors say Australia needs to better protect school kids from #COVID19 through measures incl masks & vaccination” Thanks @sophiescott2 & @leonie_thorne @abcnews for informed & non alarmist article feat me & @NjbBari3 Thread🧵👇 #LongCovid #LongCovidKids [Tweet]. @drgregkelly. https://twitter.com/drgregkelly/status/1412160336497561604

ReconfigBehSci. (2021, January 29). RT @IndependentSage: 3.7 million infected with #COVID19 in the UK. An estimated 5-10% will develop #LongCovid. We can’t afford to ignore th… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1355097550529945607

(1) ReconfigBehSci on Twitter: ‘RT @ahandvanish: New paper on 10,024 breakthrough infections shows that vaccination does not prevent #LongCovid. Https://t.co/8WurrqXRwy…’ / Twitter. (n.d.). Retrieved 29 October 2021, from https://twitter.com/SciBeh/status/1453638123624226822

What do we know about Covid’s impact on the brain? (2022, March 9). The Guardian. https://www.theguardian.com/commentisfree/2022/mar/09/covid-coronavirus-brain-study-eric-topol

Study finds brain changes similarly to Alzheimer’s after COVID-19. (n.d.). The Jerusalem Post | JPost.Com. Retrieved March 31, 2022, from https://www.jpost.com/health-and-wellness/coronavirus/article-696565

Singh, I., Joseph, P., Heerdt, P. M., Cullinan, M., Lutchmansingh, D. D., Gulati, M., Possick, J. D., Systrom, D. M., & Waxman, A. B. (2022). Persistent Exertional Intolerance After COVID-19: Insights From Invasive Cardiopulmonary Exercise Testing. CHEST, 161(1), 54–63. https://doi.org/10.1016/j.chest.2021.08.010

Lehnen, N., Glasauer, S., Schröder, L., Regnath, F., Biersack, K., Bergh, O. V. den, & Werder, D. von. (2022). Post-COVID symptoms in the absence of organic deficit—Lessons from diseases we know. PsyArXiv. https://doi.org/10.31234/osf.io/yqar2

Health & Veritas: Is Long COVID One Disease or Many? (Ep. 19). (n.d.). Yale Insights. Retrieved 21 March 2022, from https://insights.som.yale.edu/insights/health-veritas-is-long-covid-one-disease-or-many-ep-19

Lopez-Leon, S., Wegman-Ostrosky, T., Valle, N. C. A. del, Perelman, C., Sepulveda, R., Rebolledo, P. A., Cuapio, A., & Villapol, S. (2022). Long COVID in Children and Adolescents: A Systematic Review and Meta-analyses. (p. 2022.03.10.22272237). medRxiv. https://doi.org/10.1101/2022.03.10.22272237

ReconfigBehSci. (2022, February 20). RT @Gemma_clark14: Great video of @dgurdasani1 discussing the Covid stats and the effect on children #LongCovidKids https://t.co/T8t4G3Rfpw [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1495705778044510214

Tapper, J. (2022, March 5). Covid pandemic sparks steep rise in number of people in UK with long-term illness. The Observer. https://www.theguardian.com/society/2022/mar/05/covid-pandemic-sparks-steep-rise-in-number-of-people-in-uk-with-long-term-illness

Cox, D. (n.d.). How children are being affected by long Covid. Retrieved March 7, 2022, from https://www.bbc.com/future/article/20220225-are-children-at-risk-of-long-covid

Bromwich, Kathryn. ‘How Long Covid Forced Me to Confront My Past and My Identity’. The Observer, 8 November 2020, sec. World news. https://www.theguardian.com/world/2020/nov/08/how-long-covid-forced-me-to-confront-my-past-and-my-identity.

Anthony J Leonardi, PhD, MS. (2022, February 28). Damn, nice find https://t.co/cJRhB2k4zH [Tweet]. @fitterhappierAJ. https://twitter.com/fitterhappierAJ/status/1498113886846914567

Dr. Deepti Gurdasani. (2022, February 21). Did anyone hear any mention of long COVID, an illness affecting 1.3 million people, of whom 500,000 have had this for more than a year during the briefing? Are we just going to pretend it doesn’t exist? [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1495839416262311938

indie_SAGE. (2022, February 11). Indie_SAGE 11.02.2022. https://www.youtube.com/watch?v=0GC9QsKfrNc

Schreiber, M. (2022, February 18). Covid infection increases risk of mental health disorders, study finds. The Guardian. https://www.theguardian.com/world/2022/feb/18/covid-infection-increases-risk-mental-health-disorder-study

Dr Ellie Murray, ScD 🇨🇦. (2022, February 18). If you have a little one who’s getting a vaccine soon but feeling a bit scared, this new book from @JanZauzmer is quite cute & might help them preview the experience. #VaccinesSaveLives https://t.co/MRngUYWsOJ [Tweet]. @EpiEllie. https://twitter.com/EpiEllie/status/1494695602248200198

https://ukhsa.koha-ptfs.co.uk/cgi-bin/koha/opac-retrieve-file.pl?id=fe4f10cd3cd509fe045ad4f72ae0dfff

Spinney, L. (2022). Pandemics disable people—The history lesson that policymakers ignore. Nature, 602(7897), 383–385. https://doi.org/10.1038/d41586-022-00414-x

APPG on Coronavirus. (2022, January 18). 🗣Dr.Claire Steves continued: “Looking in the national core studies, from cohort studies across the UK we’ve looked at 10 different longitudinal studies. Our best estimates are that about 5% of middle aged people are experiencing long term.. 27/ #APPGCoronavirus #LongCovid [Tweet]. @AppgCoronavirus. https://twitter.com/AppgCoronavirus/status/1483453895061999618

Deepti Gurdasani. (2022, February 8). Exactly this 👇 We never talk about the huge benefits mitigations have had in reducing other respiratory illnesses... Which means deaths from other causes have reduced. Excess deaths are not a good indicator of COVID-19 deaths—Which we should be doing a lot more to prevent! [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1491123632349024256

ReconfigBehSci on Twitter: ‘RT @T2Fox61: .@YaleMed immunobiologist @VirusesImmunity leading research into long #COVID19. @FOX61News https://t.co/oyZSGwRNcS’ / Twitter. (n.d.). Retrieved 13 February 2022, from https://twitter.com/SciBeh/status/1484805325886832640

Su, Y., Yuan, D., Chen, D. G., Ng, R. H., Wang, K., Choi, J., Li, S., Hong, S., Zhang, R., Xie, J., Kornilov, S. A., Scherler, K., Pavlovitch-Bedzyk, A. J., Dong, S., Lausted, C., Lee, I., Fallen, S., Dai, C. L., Baloni, P., … Heath, J. R. (2022). Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae. Cell, 0(0). https://doi.org/10.1016/j.cell.2022.01.014

COVID-19 takes serious toll on heart health—A full year after recovery. (n.d.). Retrieved February 11, 2022, from https://www.science.org/content/article/covid-19-takes-serious-toll-heart-health-full-year-after-recovery

Jetelina, K. (2022, January 13). State of Affairs: Pediatrics and Omicron [Substack newsletter]. Your Local Epidemiologist. https://yourlocalepidemiologist.substack.com/p/state-of-affairs-pediatrics-and-omicron

AbScent. (2022, February 7). ⁦the study quoted here looked at an 18 month time interval. In our Covid19 FB group of 34.5k, we have reports of recovery after 18 months—2 years is not unknown @Dr_Ellie⁩ ⁦@MailOnline⁩ https://t.co/5DdXDWLBSQ [Tweet]. @AbScentUK. https://twitter.com/AbScentUK/status/1490636119322644484

Yaneer Bar-Yam on Twitter. (n.d.). Twitter. Retrieved February 7, 2022, from https://twitter.com/yaneerbaryam/status/1474091037861761026

Trisha Greenhalgh. (2022, January 8). Apart from (e.g.): 1. Severe disease in clinically vulnerable (they are people too); 2. Long covid in many; 3. Strokes / heart attacks / kidney failure from micro-clots; 4. New-onset diabetes and MIS-C in children; 5. High potential for recombinant mutations. [Tweet]. @trishgreenhalgh. https://twitter.com/trishgreenhalgh/status/1479738523511136258

Elaine Maxwell. (2022, February 3). In the latest @ONS estimates of #LongCovid (up to 2nd Jan 2022), only 87 thousand of the 1.33 million cases were admitted to hospital with their acute Covid19 infection. [Tweet]. @maxwele2. https://twitter.com/maxwele2/status/1489179055412989953

A cause of America’s labor shortage: Millions with long COVID. (n.d.). Retrieved February 2, 2022, from https://www.cbsnews.com/news/long-covid-labor-market-missing-workers/

Deepti Gurdasani. (2022, January 29). Going to say this again because it’s important. Case-control studies to determine prevalence of long COVID are completely flawed science, but are often presented as being scientifically robust. This is not how we can define clinical syndromes or their prevalence! A thread. [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1487366920508694529

Deepti Gurdasani. (2022, January 30). Have tried to now visually illustrate an earlier thread I wrote about why prevalence estimates based on comparisons of “any symptom” between infected cases, and matched controls will yield underestimates for long COVID. I’ve done a toy example below here, to show this 🧵 [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1487578265187405828

ScienceUpFirst, LaScienced’Abord. (2022, February 1). Got Omicron? You are not alone! See our thread on what we know so far 👇 🧵 [1/11] #ScienceUpFirst https://t.co/7Hi3lHo5LS [Tweet]. @ScienceUpFirst. https://twitter.com/ScienceUpFirst/status/1488601396421316613

Tayag, Y. (2022, January 31). What causes long Covid? Scientists are zeroing in on the answer. Vox. https://www.vox.com/22906853/omicron-long-covid-vaccinated-symptoms-cause

Routen, A., O’Mahoney, L., Ayoubkhani, D., Banerjee, A., Brightling, C., Calvert, M., Chaturvedi, N., Diamond, I., Eggo, R., Elliott, P., Evans, R. A., Haroon, S., Herret, E., O’Hara, M. E., Shafran, R., Stanborough, J., Stephenson, T., Sterne, J., Ward, H., & Khunti, K. (2022). Understanding and tracking the impact of long COVID in the United Kingdom. Nature Medicine, 28(1), 11–15. https://doi.org/10.1038/s41591-021-01591-4

ReconfigBehSci. (2022, January 21). RT @IndependentSage: Today at 1.30pm, Independent SAGE will discuss shaping policy to help Long Covid sufferers, with special guests includ… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1484475503394406402

Coronavirus: Inside a long COVID clinic as patient who was “fit and healthy” can now “barely do anything.” (n.d.). Sky News. Retrieved January 25, 2022, from https://news.sky.com/story/coronavirus-inside-a-long-covid-clinic-as-patient-who-was-fit-and-healthy-can-now-barely-do-anything-12522619

WHO/Europe. (2022, January 24). 732 days of #COVID19 in the WHO European Region – in 15 figures 👉 https://bit.ly/3rHKfAB Find out more in the thread 👇 https://t.co/3QGLeQ4jsO [Tweet]. @WHO_Europe. https://twitter.com/WHO_Europe/status/1485650319489052674

Zhao, S., Shibata, K., Hellyer, P. J., Trender, W., Manohar, S., Hampshire, A., & Husain, M. (2022). Rapid vigilance and episodic memory decrements in COVID-19 survivors. Brain Communications, 4(1), fcab295. https://doi.org/10.1093/braincomms/fcab295

Frere, J. J., Serafini, R. A., Pryce, K. D., Zazhytska, M., Oishi, K., Golynker, I., Panis, M., Zimering, J., Horiuchi, S., Hoagland, D. A., Moller, R., Ruiz, A., Overdevest, J. B., Kodra, A., Canoll, P. D., Goldman, J. E., Borczuk, A. C., Chandar, V., Bram, Y., … tenOever, B. (2022). SARS-CoV-2 infection results in lasting and systemic perturbations post recovery (p. 2022.01.18.476786). https://doi.org/10.1101/2022.01.18.476786

Townsend, L., Dyer, A. H., Naughton, A., Kiersey, R., Holden, D., Gardiner, M., Dowds, J., O’Brien, K., Bannan, C., Nadarajan, P., Dunne, J., Martin-Loeches, I., Fallon, P. G., Bergin, C., O’Farrelly, C., Cheallaigh, C. N., Bourke, N. M., & Conlon, N. (2021). Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health. Frontiers in Immunology, 12. https://www.frontiersin.org/article/10.3389/fimmu.2021.676932

James 💙 Neill - 😷 🇪🇺🇮🇪🇬🇧🔶. (2022, January 4). I hate it when I have to keep increasing the y-axis... #Omicron is #NotMild #LongCovidKids #SpotCovid https://t.co/rRBQveLqFa [Tweet]. @jneill. https://twitter.com/jneill/status/1478514263882932235

Up the line to death: Covid-19 has revealed a mortal betrayal of the world’s healthcare workers. (2021, January 29). The BMJ. https://blogs.bmj.com/bmj/2021/01/29/up-the-line-to-death-covid-19-has-revealed-a-mortal-betrayal-of-the-worlds-healthcare-workers/

Banerjee, A. (2022, January 12). I’m leading a long Covid trial – it’s clear Britain has underestimated its impact. The Guardian. https://www.theguardian.com/commentisfree/2022/jan/12/long-covid-trial-britain-short-term-virus

Fernandez-Castaneda, A., Lu, P., Geraghty, A. C., Song, E., Lee, M.-H., Wood, J., Yalcin, B., Taylor, K. R., Dutton, S., Acosta-Alvarez, L., Ni, L., Contreras-Esquivel, D., Gehlhausen, J. R., Klein, J., Lucas, C., Mao, T., Silva, J., Pena-Hernandez, M., Tabachnikova, A., … Monje, M. (2022). Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain (p. 2022.01.07.475453). https://doi.org/10.1101/2022.01.07.475453

Herman, J. (2021, December 22). More than a million of us are suffering with long Covid – yet still it’s not taken seriously. The Guardian. https://www.theguardian.com/commentisfree/2021/dec/22/long-covid-pandemic-support-funding

Simon, M. A., Luginbuhl, R. D., & Parker, R. (2021). Reduced Incidence of Long-COVID Symptoms Related to Administration of COVID-19 Vaccines Both Before COVID-19 Diagnosis and Up to 12 Weeks After (p. 2021.11.17.21263608). https://doi.org/10.1101/2021.11.17.21263608

New Study Finds Vaccine Dose Timing Reduces Risk of Long-COVID in Unvaccinated Patients. (2021, December 15). Arcadia.Io. https://arcadia.io/press-release-vaccine-dose-timing-reduces-long-covid-risk/

Lubell, M. (2021, December 9). Doctors weigh COVID-19 impact on children as vaccine drives ramp up. Reuters. https://www.reuters.com/business/healthcare-pharmaceuticals/doctors-weigh-covid-19-impact-children-vaccine-drives-ramp-up-2021-12-09/

Ayoubkhani, D., Bermingham, C., Pouwels, K. B., Glickman, M., Nafilyan, V., Zaccardi, F., Khunti, K., Alwan, N. A., & Walker, A. S. (2021). Changes in the trajectory of Long Covid symptoms following COVID-19 vaccination: Community-based cohort study (p. 2021.12.09.21267516). https://doi.org/10.1101/2021.12.09.21267516

West Country Bylines. ‘Covid-19: 2 Months since “Freedom Day”, but Where Are We Now?’, 1 October 2021. https://westcountrybylines.co.uk/covid-19-2-months-since-freedom-day-but-where-are-we-now/.

Scott, Jake, Aaron Richterman, and Muge Cevik. ‘Covid-19 Vaccination: Evidence of Waning Immunity Is Overstated’. BMJ 374 (23 September 2021): n2320. https://doi.org/10.1136/bmj.n2320.

Otte, J. (2021, November 11). ‘No jab, no job’: Care home workers in England on the Covid vaccine mandate. The Guardian. https://www.theguardian.com/society/2021/nov/11/england-care-home-workers-on-mandatory-covid-vaccines

Gurdasani, D., Bhatt, S., Costello, A., Denaxas, S., Flaxman, S., Greenhalgh, T., Griffin, S., Hyde, Z., Katzourakis, A., McKee, M., Michie, S., Ratmann, O., Reicher, S., Scally, G., Tomlinson, C., Yates, C., Ziauddeen, H., & Pagel, C. (2021). Vaccinating adolescents against SARS-CoV-2 in England: A risk–benefit analysis. Journal of the Royal Society of Medicine, 01410768211052589. https://doi.org/10.1177/01410768211052589

Alwan, N. A. (2021). We must call out childism in covid-19 policies. BMJ, 375, n2641. https://doi.org/10.1136/bmj.n2641