164 Matching Annotations
  1. Last 7 days
    1. This research supports the idea that the more fruit and veg you eat the better – at least, up to 10 portions (800g) a day.
    1. Many countries - including Germany, the Netherlands and New Zealand - recommend five portions a day. Some others - including Canada and Japan - recommend seven or more. France goes as far as recommending 10 portions of fruit and vegetables a day. In Australia, they say the emphasis should be on eating more vegetables than fruit and recommend five portions of vegetables and two of fruit per day.
    1. In his letter, Sir Tim outlined three specific areas of "dysfunction" that he said were harming the web today: malicious activity such as hacking and harassment problematic system design such as business models that reward clickbait unintended consequences, such as aggressive or polarised discussions

      If this is resolved, I believe that many individuals can be helped to feel a lot better.

    1. is a waterborne bacterial disease, caused by the leptospiro bacteria. It rarely spreads from person to person and can be treated with common antib

      The bacteria is found in the urine of rodents.

  2. Mar 2019
    1. Now, as part of my regular practice, I spend about five minutes out of each hour exercising with this package. This almost always reveals things to me that change at least the slant of my approach during the next hour, and often stimulates a relatively significant change in my short-range plans.

      Also starting to think about health/exercise monitoring software here.

  3. Feb 2019
  4. Jan 2019
    1. I used to be comforted by their cheering words, by the hours they spent at my bedside, and by their conversation.

      Chicken soup for the self-writer's soul? Jk.

      Yet another thing words can do: heal.

    1. So if you are tired during the day, check that you’re giving yourself the opportunity to get 7 to 9 hours.

      This is super helpful. Bold

    2. So if you are tired during the day, check that you’re giving yourself the opportunity to get 7 to 9 hours.

      This is super helpful.

  5. Dec 2018
  6. Nov 2018
    1. Davis and col-leagues (3) provide useful new data that enhance our un-derstanding of the effects of hospitalists on health sys-tems. In their study of a voluntary hospitalist system at alarge rural nonteaching hospital in Mississippi, theyfound that patients cared for by hospitalists had adjustedhospital stays that were 25% shorter, and costs that were12% less, than patients cared for by nonhospitalist inter-nists. For patients in the highest severity group, these sav-ings were even greater. Annualized, the authors extrapo-late that the hospitalists would have saved $2.5 millionhad they cared for all of the internists’ patients. As withprior studies that found similar reductions in resourceuse (4 –7), these substantial savings were achieved with-out diminishing quality or patient satisfaction. Nor wasthere evidence of cost shifting: hospitalists’ patients wereno less likely to be discharged to home (instead of anotherinstitution such as a skilled nursing facility) than werepatients of primary care internists. We can now state withconsiderable confidence that hospitalists markedly de-crease inpatient costs and lengths of stay with no compro-mise in quality or patient satisfaction.
    1. Meditation can not only provide a welcome counterweight to this work with abstractions, it also cultives 10 qualities of character (Pali: paramis) that are useful during the practice of programming.

      Generosity Morality Renunciation Understanding Effort Patience/tolerance Truthfulness Loving-kindness Equanimity

    1. Polls show that doctors are trusted by the public more than politicians, which means it’s hard for public policy to shape the healthcare system unless medical associations sign off on it.
    1. “It’s about embracing the inscrutable nature of human interactions,” says Chang. Evidence-based medicine was a massive improvement over intuition-based medicine, he says, but it only covers traditionally quantifiable data, or those things that are easy to measure. But we’re now quantifying information that was considered qualitative a generation ago.

      Biggest challenges to redesigning the health care system in a way that would work better for patients and improve health

    2. “Our biggest opportunity is leaning into that. It’s either embracing the qualitative nature of that and designing systems that can act just on the qualitative nature of their experience, or figuring how to quantitate some of those qualitative measures,” says Chang. “That’ll get us much further, because the real value in health care systems is in the human interactions. My relationship with you as a doctor and a patient is far more valuable than the evidence that some trial suggests.”

      Biggest challenges to redesigning the health care system in a way that would work better for patients and improve health

    3. Duffy points to the increase in health care interactions online and adds that he would like to see a pervasive culture of in-person care as last resort. “If every organizational decision, technology decision, process decision — assuming all the payment stuff, that’s kind of ticket of entry, transpires — if you view in-person as last resort, that will help pull systems across the country to a more consumer-forward Uber-like experience,” he says

      Biggest challenges to redesigning the health care system in a way that would work better for patients and improve health

    1. As with other forms of value-based health care, patient-centered care requires a shift in the way provider practices and health systems are designed, managed, and reimbursed. In keeping with the tenets of patient-centeredness, this shift neither happens in a vacuum, it driven by traditional hierarchies in which providers or clinicians are the lone authority. Everyone, from the parking valet and environmental services staff to c-suite members, are engaged in the process, which impacts hiring, training, leadership style, and organizational culture. Patient-centered care also represents a shift in the traditional roles of patients and their families from one of passive “order taker” to one of active “team member.” One of the country’s leading proponents of patient-centered care, Dr. James Rickert, has stated that one of the basic tenets of patient-centered care is that “patients know best how well their health providers are meeting their needs.” To that end, many providers are implementing patient satisfaction surveys, patient and family advisory councils, and focus groups, and using the resulting information to continuously improve the way health care facilities and provider practices are designed, managed, and maintained from both a physical and operational perspective so they become centered more on the individual person than on a checklist of services provided. As the popularity of patient- and family-centered health care increases, it is expected that patients will become more engaged and satisfied with the delivery of their care, and evidence of its clinical efficacy should continue to mount.

      Cultural shift to patient-centered care

    1. Poor health literacy is a silent and ubiquitous health care issue, and the field of neurosurgery is particularly prone to the consequent adverse effects. Failure to address low health literacy has several detrimental health and economic consequences, and numerous policies have been initiated to address these. Better facilitating patient understanding of neurosurgical disease, treatment options, and care surrounding the operative period may have a positive impact on the health care economy and ultimately achieve improved outcomes for patients.

      Certain disciplines are particularly prone to consequent adverse effects of poor health literacy.

    2. Deyo et al. (8) demonstrated a reduction in the adverse impact of inadequate health literacy in the neurosurgical field. The impact of an interactive videodisc program that informs patients of their treatment options for back surgery on patient outcome and surgical choices was evaluated. The program helped facilitate decision making and ensured informed consent. It also reduced surgery rates for patients with herniated disks. The authors of this study also implemented the use of patient-oriented multimedia to augment comprehension and advocated a similar strategy for other clinicians. Further commitment is needed to put health literacy at the forefront of improving health care and reducing health expenditures, especially in neurosurgery.
    3. Paasche-Orlow et al. (18) suggested 3 principles to ameliorate health literacy disparities. The first is to promote productive interactions. Clinicians need to develop better communication abilities and take appropriate measures to ensure adequate comprehension of health information. Educating youth and establishing health literacy standards in the educational system can help improve existing and future health literacy rates. Incorporating health literacy classes as a component of training for health professionals and in studies of preventive services can increase awareness among providers, facilitating better communication and quality of care (19). Additionally, transmitting complex ideas can be aided with the use of technology platforms. Yin et al. (25) investigated the plausibility of a pictogram-based intervention program to reduce medication administration errors. The authors found that when the intervention was used as part of medication counseling, there was a decrease in medication dosage errors compared with standard medication counseling.The second principle is concerned with addressing the organization of health care. Paasche-Orlow et al. advocated patient-centered care, streamlined access to health care, and incentives to promote collaboration to address the needs of the health illiterate population. The U.S. government created and enacted several major policies that address this principle to diminish the adverse effects of poor health literacy. The first is the Affordable Care Act, which stipulates that health plans and insurers must provide understandable and clear health information regarding coverage and benefits (11). Because most Americans receiving coverage through the new legislative act have limited health literacy, standardized information about health care would greatly assist these Americans in making better-informed health decisions (15). Another policy is the National Action Plan to Improve Health Literacy (22). This is the first plan of its kind to create health literacy goals for the entire country. It intends to provide all Americans with access to accurate health information, deliver patient-focused services, and support learning and skills that improve health. All of these acts and policies have the potential to improve 3 keys to health care: access, quality, and cost.The third principle from the study by Paasche-Orlaw et al. involves establishing an objective and sincere voice for better delivery of health information to the community. Individuals may have appropriate health literacy levels, but other personal or environmental factors can contribute to a lower understanding of vital health information. Ito (9) analyzed Vietnamese refugees who tested positive for inactive tuberculosis and their response to prophylactic tuberculosis treatment. Ito found that the immigrants were more hesitant to complete the medication regimen because the side effects were too “hot.” Instead, the immigrants preferred Asian herbal medications as they were considered “cooling.” Von Goeler et al. (23) investigated diabetes self-management among Puerto Rican adults with type 2 diabetes and found that the participants regularly self-monitored their blood glucose levels. However, they did not use that information to control their diabetes properly because of financial and social barriers such as competing family concerns. Situations such as these call for a voice, a cultural broker, who understands the environmental obstacles to comprehending and using health information fully.

      Ameliorate health literacy disparities

    4. Koh et al. (11) detailed a cycle of crisis care elaborating the nature of high medical costs, possibly resulting from fear and denial. First, an individual is in need of medical help, so he or she goes to a physician's office where the staff asks the individual to fill out a complex and confusing form. The physician examines the patient and explains the condition and treatment options using medical jargon. Numerous prescriptions, laboratory tests, and referrals are given without confirmation of the patient's comprehension. The staff sends the patient home with complicated instructions. Inevitably, the patient may consume medication incorrectly or miss follow-up appointments, and his or her condition worsens. Eventually, the patient presents to the emergency department, and the hospital staff develops a new treatment plan. Again, no one confirms the patient's understanding. When the patient is discharged, he or she is likely to get sick again and repeat the cycle (11)
  7. Oct 2018
    1. Silvia’s father went to prison when she was a baby, and served 10 years for selling drugs. Without his support, her mother struggled to provide financially for her and her brother. Her mother also suffered from a mental disorder for which she received SSI. While Silvia was growing up, the family relied on public assistance and ate mostly cheap food such as canned ravioli and Ramen noodles. Silvia remembers being hungry often and recalls that her mother often ignored Silvia and her brother.

      Pienso que esto es Pathway effect en cuanto a que Silvia de alguna manera reprodujo lo que vio en su hogar porque ya tenia un escenario predispuesto. El health behavior que quiero destacar es el comportamiento en cuanto a la dieta ya que eran pobres y comía comida enlatada no saludable y no tenían seguridad alimentaria.

    1. They found that an hour after being released in a room at a relative humidity of 23% or less, 70-77% of viral particles retained their infectious capacity, but when humidity was increased to about 43%, only 14% of the virus particles were capable of infecting cells. Most of this inactivation occurred within the first fifteen minutes of the viral particles being released in the high-humidity condition. The study concludes that maintaining indoor relative humidity at levels greater than 40% can significantly reduce the infectious capacity of aerosolized flu virus.
    1. A review of the health effects of relative humidity in indoor environments suggests that relative humidity can affect the incidence of respiratory infections and allergies. Experimental studies on airborne-transmitted infectious bacteria and viruses have shown that the survival or infectivity of these organisms is minimized by exposure to relative humidities between 40 and 70%. Nine epidemiological studies examined the relationship between the number of respiratory infections or absenteeism and the relative humidity of the office, residence, or school. The incidence of absenteeism or respiratory infections was found to be lower among people working or living in environments with mid-range versus low or high relative humidities. The indoor size of allergenic mite and fungal populations is directly dependent upon the relative humidity. Mite populations are minimized when the relative humidity is below 50% and reach a maximum size at 80% relative humidity. Most species of fungi cannot grow unless the relative humidity exceeds 60%. Relative humidity also affects the rate of offgassing of formaldehyde from indoor building materials, the rate of formation of acids and salts from sulfur and nitrogen dioxide, and the rate of formation of ozone. The influence of relative humidity on the abundance of allergens, pathogens, and noxious chemicals suggests that indoor relative humidity levels should be considered as a factor of indoor air quality. The majority of adverse health effects caused by relative humidity would be minimized by maintaining indoor levels between 40 and 60%. This would require humidification during winter in areas with cold winter climates. Humidification should preferably use evaporative or steam humidifiers, as cool mist humidifiers can disseminate aerosols contaminated with allergens.
  8. Sep 2018
    1. So a weighted blanket it is. “We’re not understanding how to deal with [mental health]. Instead, we’re throwing products at it,” says Beautiful Voyager’s Arthur. “It’s very American.”

      Or: we are making certain tools, which used to be niche and therefore expensive and hard to find, widely available.

    2. So, yes, meditation apps may help us meditate, and meditation may reduce anxiety. Weighted blankets may calm us down long enough to fall and stay asleep, which will help us feel better the next day. And fidget devices can distract us so that instead of ruminating on negative thoughts, we’re expending mental energy on something physical.

      Products that are designed for people with disabilities often have benefits even for those without that disability. That does mean the product cures or treats an underlying condition. It's just a tool.

    3. There are plenty of places to point fingers: your phone, the president, climate change, the recession, FOMO, divorce, social media, student debt, terrorism, the 24-hour news cycle, the economy, “the economy,” living farther from family, toxins in your gut, too many choices, too little sleep, too little sex. Or maybe we’re just overdiagnosing anxiety and actually, everything’s fine.

      Or maybe reduced stigma against mental health combined with wider access to health insurance under the Affordable Care Act has allowed more people to seek help. I don't think anxiety is any more prevalent than it was before; I think more of us are talking about it.

    1. mental health and addiction services

      Assess the prevalence and incidence of mental health issues and addictions and establish sufficient services for caring and prevention. This phenomena affect workers, their families and communities.

    2. medical care

      Improve medical care infrastructure and inter-provincial agreements to be able to cover LC-LD workers and their families in source, host and hub communities in a timely manner. the improvement of such services should be flexible enough to adapt to the ups and downs of the predominant industries.

    1. Matthew Mayer, a professor of educational psychology at Rutgers’ Graduate School of Education, says that among experts the best solutions to school shootings are not really in dispute: basic gun control, more and better mental-health services and a robust national threat-assessment program. We also need to help educators create an atmosphere where students who hear about a potential threat feel comfortable sharing that information with adults. (Many student shooters, including Gabe Parker at Marshall County, hint about their plans to at least one other person or tell them outright. Getting those others to inform teachers is one of our best options for preventing shootings from happening in the first place.) In February, Mayer and his colleagues circulated an eight-point document titled “A Call for Action to Prevent Gun Violence in the United States of America,” which summarized these and other key actions needed to reduce the risk of school shootings. So far, 4,400 educators and public-health experts have signed it. But political will is still missing. “We keep revisiting the same conversations every five or six years without learning or changing much of anything,” Mayer says. “Armed guards and metal detectors make it look like you’re doing something. You get far fewer points for talking about school climate and mental health.”
  9. Aug 2018
    1. Anomie (/ˈænəˌmi/) is a "condition in which society provides little moral guidance to individuals".[1] It is the breakdown of social bonds between an individual and the community, e.g., under unruly scenarios resulting in fragmentation of social identity and rejection of self-regulatory values.

      I can't help but see this definition and think it needs to be applied to economics immediately. In particular I can think of a few quick examples of economic anomie which are artificially covering up a free market and causing issues within individual communities.

      College Textbooks: Here publishers are marketing to professors who assign particular textbooks and subverting students which are the actual market and consumers of those textbooks. This causes an inflated market and has allowed textbook prices to spiral out of control.

      The American Health Care Market In this example, the health care providers (doctors, hospitals, etc.) have been segmented away from their consumers (patients) by intermediary insurance companies which are driving the market to their own good rather than a free-er set of smaller (and importantly local) markets that would be composed of just the sellers and the buyers. As a result, the consumer of health care has no ability to put a particular price on what they're receiving (and typically they rarely ever ask, even more so when they have insurance). This type of economic anomie is causing terrific havoc within the area.

      (Aside: while the majority of health care markets is very small in size (by distance), I will submit that the advent of medical tourism does a bit to widen potential markets, but this segment of the market is tiny and very privileged in comparison.)

    1. The technical and theoretical details underlying clinical informatics are beyond the scope of this chapter. What follows is a concise introduction to topics and resources of general interest in this field, presented to help clinicians use information technology for the benefit of patient care.

      This is interesting!

    1. She reached behind her to her bookshelf, which held about a dozen blue bottles of something called Real Water, which is not stripped of “valuable electrons,” which supposedly creates free radicals something something from the body’s cells.

      I question her credibility to market claims like this. I suspect she has no staff scientist or people with the sort of background to make such claims. Even snake oil salesmen like Dr. Oz are pointedly putting us in hands way too make a buck.

  10. Jul 2018
    1. A 2016 Lancet study found that universal breast-feeding would prevent 800,000 child deaths a year across the globe and yield $300 billion in savings from reduced health care costs and improved economic outcomes for those reared on breast milk.

      Pure corruption here. Protectionism to prop up profits of approximately 630 million versus major benefits and savings of 300 billion. Even if you look at the calculus of the entire industry of 70 billion it becomes a no brainer.

  11. May 2018
    1. There are many resources available to help you and your health care proxy develop a care plan. These are merely suggestions to get you thinking about possible scenarios and topics to discuss. I hope you found this blog informative, and urge you to share it with anyone who does not have a health care proxy. We always think it will never happen to us, but what if it does? It's best to be prepared!

      The article highlights the importance of what a good health proxy looks like and how they go about helping a patient in their most sensitive moments of health and later on in their lives. Potentially, this could be a good chance for a client's wishes to be fully respected by someone who knows of their values and preferences. It also encourages the reader to be prepared incase they are faced with this decision some day. Many members of the elder population are asked about healthcare proxies during the beginning of any hospitalization. More awareness of what a health proxy is and what social supports a patient can count on helps to assure quality care and dignity in health and death.

    2. Further, a doctor, medical center, hospital, EMT, and even assisted living staff can make decisions regarding your healthcare, treatment methods and type of medical care to provide you if you are not married, over 18 years old, and do not have a health care proxy in place

      Medical decision making has very specific in rules to protect the rights of the patient. The rules can vary according to a patient's age, marital status, and wether or not they signed a health care proxy document in the first place.

    3. Who would decide what was best for you? Who would advocate on your behalf?

      This is a scary question that most people in the United States have to consider at one point in their life. Trust in the person in charge of making medical decisions is essential.

    4. Health care proxy: An advance medical directive in the form of a legal document that designates another person (a proxy) to make health care decisions in case a person is rendered incapable of making his or her wishes known.

      The medical definition of a health care proxy- a legal medical document that transfers power of medical decision making from a patient to a trusted person.

    1. The question each proxy should ask when making decisions on behalf of others is, who am I truly serving — the patient or myself?

      This article really high lights the potential negatives of the concept of healthcare proxies and provides real life scenarios to help the reader relate.

    2. When the patient is unwilling or unable to make medical decisions, the health care proxy is activated and he or she is obligated to make all health choices on behalf of the patient. These may be related to withdrawing or withholding life support, instituting artificial liquid feeding, attempting resuscitation and even whether or not to participate in autopsy and organ donation.

      Any decisions regarding the care and body of the patient are headed over to their health proxy, who assumes any medical decision making responsibilities from there.

  12. Mar 2018
    1. Many lives have been saved by parents doing something simple. Beginning in the 1960s American military doctors and researchers in Dhaka developed a therapy for acute diarrhoea—a sweet, salty oral rehydration solution. This is now dirt cheap and widely available. At the last count, fully 84% of Bangladeshi parents with stricken children fed it to them (only a third saw a doctor). Thinly populated African countries are struggling to match that. One promising idea is to distribute the sachets along with Coca-Cola—which gets everywhere.

      amazing the reach of Coca-Cola!

    2. many Indians continue to defecate in the open. Bangladesh’s government and charities have built latrines, too, but they have worked harder to stigmatise open defecation. Often they install latrines for the poor and then prod richer folk into following their example. A new, surprising, finding is that this works better than expecting people to copy their social superiors.
    1. have been selectively bred

      There's a difference between selective breeding and altering via genetic engineering. I believe that genetic modification falls into the second category, always.

  13. Feb 2018
    1. Cow Milk Benefits many and in multiple ways. Cow Milk Benefits those looking to lose some weight. It works as a healthy snack in one's diet and adds a great appetizer to their diet. One of the other milk benefits for health from cow milk is that it is great stress buster and it helps in better concentration and focus.

  14. Jan 2018
    1. Milk is the primary source of nutrition to the new born babies. It is consumed by people of every age. Milk Benefits For Health by its contents like Vitamin D, Vitamin B12, Vitamin A, riboflavin, protein, phosphorous, calcium and potassium.

  15. Dec 2017
    1. The domain of personalised medicine, in particular, is overflowing with possibilities for innovation [3].

      Learn more about this.

  16. Nov 2017
    1. Government announces it has secured a major strategic investment into UK by MSD ahead of this morning’s publication of its flagship Industrial Strategy Landmark investment comes as a huge vote of confidence in the government’s approach to industrial strategy, with the global healthcare company committing to open a new world-class hub in the UK
    1. The five conditions with the highest burden are (in order) depression, bipolar disorder, alcohol use disorders, social phobia and schizophrenia.

      it the order from least to most?

    2. Lots of great video resources surrounding Mental Health (PSAs, one-on-one interviews, etc).

    1. Then Dan Bloomfield reviews what makes nature-based interventions in mental health successful. Follow-ing this there are two accounts of using green spaces in mental health services, from Australia and the UK.

      This is interesting.

  17. Oct 2017
    1. Leave a Reply

      This comment was submitted but has not yet been approved:

      “However government data says that 28% people in India use one of more kind of AYUSH treatments.”

      and

      “The WHO states that Homeopathy is the second most used medical system internationally,”

      Can you say where that comes from? I can’t find the second on in that WHO reports.

  18. Sep 2017
    1. Large computer networks (and their associated users) may “wake up” as superhumanly intelligent entities.

      The author refers to both the computer network and its user when he refers to them "waking up." This may be a prediction of a soon to be symbiotic relation to us and technology. We are already using technology to mange our social life, our infrastructure, and even our health with pacemaker. We are already living in a world where we are inseparable from technology, but will we one day be completely be inseparable?

  19. May 2017
    1. Section 139A of the Internal Revenue Code of 1986 is amended by adding at the end the following new sentence: “This section shall not be taken into account for purposes of determining whether any deduction is allowable with respect to any cost taken into account in determining such payment.”.

      This is important.

    1. American Industrial Health Council

      This may be a front group. Investigate, find additional sources, and leave research notes in the comments.

    2. American Industrial Health Council

      This may be a front group. Investigate, find additional sources, and leave research notes in the comments.

    1. American Industrial Health Council

      This may be a front group. Investigate, find additional sources, and leave research notes in the comments.

    2. American Industrial Health Council

      This may be a front group. Investigate, find additional sources, and leave research notes in the comments.

    1. American Industrial Health Council

      This may be a front group. Investigate, find additional sources, and leave research notes in the comments.

    2. American Industrial Health Council

      This may be a front group. Investigate, find additional sources, and leave research notes in the comments.

    1. American Industrial Health Council

      This may be a front group. Investigate, find additional sources, and leave research notes in the comments.

    2. American Industrial Health Council

      This may be a front group. Investigate, find additional sources, and leave research notes in the comments.

    1. American Industrial Health Council

      This may be a front group. Investigate, find additional sources, and leave research notes in the comments.

    2. American Industrial Health Council

      This may be a front group. Investigate, find additional sources, and leave research notes in the comments.

    1. American Industrial Health Council

      This may be a front group. Investigate, find additional sources, and leave research notes in the comments.

    2. American Industrial Health Council

      This may be a front group. Investigate, find additional sources, and leave research notes in the comments.

    1. American Industrial Health Council

      This may be a front group. Investigate, find additional sources, and leave research notes in the comments.

    2. American Industrial Health Council

      This may be a front group. Investigate, find additional sources, and leave research notes in the comments.

  20. Apr 2017
    1. I like this article, but it’s odd that the site uses a ‘reading list’ style with multiple articles in one huge list.

  21. Mar 2017
    1. Exercise is often positioned as something that always lowers blood glucose; however, high-intensity exercise, such as sprinting or weight lifting, can sometimes raise blood glucose. This stems from the adrenaline response, which tells the body to release stored glucose. Often, I find this happens when I’m exercising in the morning on an empty stomach. But this is not a reason to avoid high intensity exercise – studies show it can improve blood glucose for one to three days post-exercise! Note that in some cases high-intensity exercise can also drop blood glucose very rapidly (2-3 mg/dl per minute), especially if you have insulin on board in your pump. The best way to see how individual exercise sessions affect your blood glucose is to test prior and after activity. “The Impact of brief, high-intensity exercise on blood glucose levels” (Diabetes Metab Syndr Obes 2013)
    1. “It may sound like an incredibly bold statement, however, Dr. Bergman will discuss exactly how 97% of diseases can be prevented and cured.

      Dr. John Bergman

    1. Findings In a meta-regression analysis of 49 clinical trials with 312 175 participants, each 1-mmol/L (38.7-mg/dL) reduction in LDL-C level was associated with a relative risk (RR) of major vascular events of 0.77 (95% CI, 0.71-0.84; P < .001) for statins and 0.75 (95% CI, 0.66-0.86; P = .002) for established nonstatin interventions that act primarily via upregulation of LDL receptor expression.Meaning These data suggest statins and nonstatin therapies that act through upregulation of LDL receptor expression are associated with similar cardiovascular risk reduction per decrease in LDL-C. The clinical value of adding specific nonstatin interventions to lower LDL-C to background statin therapy should be confirmed in appropriately powered clinical trials.
    1. In addition, the vast majority of animal studies have shown that oral administration of PS reduces the progression atherosclerosis. However, it has been recently suggested that an increase in PS plasma concentrations may increase CV risk. Evidence to support this hypothesis come mainly from observations in sitosterolemic patients who hyperabsorb PS and cholesterol and display very high levels of PS, which may be associated with a premature atherosclerosis. Some epidemiological studies in non-sitosterolemic subjects have shown a positive correlation between PS plasma levels and coronary heart disease. However, these are observational studies and some of them present major methodological bias. In addition, recent studies with a larger number of subjects have indicated, either an absence or a negative relationship between PS and the incidence of CV disease.
    1. One way exercise can protect against atherosclerosis (and therefore heart disease) is by increasing shear stress on the arterial walls, which causes the endothelium to become less permeable (less accepting of oxidized LDL particles) and produce more nitric oxide (a potent inhibitor of LDL oxidation). You can think of exercise, then, not just as training for your muscles, but also for your arterial walls. It’s enough of an inflammatory stressor to induce an adaptive response. Of course, too much shear stress can be too inflammatory and might actually cause atherosclerosis to progress.
    1. The most effective approach has been minimizing fat stores located inside the abdominal cavity (visceral body fat) in addition to minimizing total body fat.[46] Visceral fat, which is more metabolically active than subcutaneous fat, has been found to produce many enzymatic signals, e.g. resistin, which increase insulin resistance and circulating VLDL particle concentrations, thus both increasing LDL particle concentrations and accelerating the development of diabetes mellitus.
    1. In summary, reducing dietary saturated fat is associated with an increase in LDL-receptor abundance of magnitude similar to the decrease in serum LDL-cholesterol. Thus, an important mechanism by which reductions in dietary saturated fatty acids decrease LDL-cholesterol in humans is through an increase in LDL-receptor number.
    1. In line with data in humans [8], feeding of dietary monounsaturated fat to nonhuman primates reduced LDL without lowering HDL, and in comparison to saturated and polyunsaturated fat, provided the lowest LDL to HDL ratio [9•]. On the other hand, replacement of some of the saturated fat with monounsaturated fat was associated with an even greater enrichment of LDL particles with cholesteryl oleate, a change in LDL particle composition that has been shown to confer atherogenicity [9•]. However, caution is needed in applying the results from animal experiments to humans.
  22. Feb 2017
    1. Request permission

      but you will have to pay in order to read the results.

      Except if you are working in science + in a university + which pays the subscription to this journal.

      Hence, a huge percentage of concerned people won't read more that these lines – full of jargon.

    2. AbstractThe main objective of this prospective longitudinal study was to investigate bidirectional associations between adolescent cannabis use (CU) and neurocognitive performance in a community sample of 294 young men from ages 13 to 20 years.

      The result of this study is of main interest for:

      • doctors
      • teachers
      • popular education associations
      • families
      • you
  23. Jan 2017
    1. The study also shows that staying up an extra hour, even if followed by a full night’s sleep, is correlated with slower performance the next day. Going to bed an hour earlier than normal, however, has a negligible effect.
    2. For example, the study shows that people who sleep less than six hours for two consecutive nights are sluggish for the next six days
  24. Nov 2016
  25. Oct 2016
  26. Sep 2016
    1. In terms of hardware, before Apple Watch debuted in 2014, there were a lot of rumors about the wearable including a multitude of health sensors that could track things like blood glucose or blood oxygen.

      A lot of these rumours appeared on 9to5mac, of course…

  27. Jul 2016
    1. The more vulnerable part of higher ed is professional master’s and certificate programs, which are long and expensive and provide more than someone needs to get the job, said Selingo, the “There Is Life After College” author.

      Speaking of PhD attrition

  28. Jun 2016
    1. What is development? How does it happen? How have ideas on development changed since the Second World War? This study guide to International Development: Ideas, Experience, and Prospects will help dig deeper into these questions. Each chapter features a summary of the main conclusions, discussion questions, and suggested readings. The Study Guide Quick Finder is at the bottom of each page.

      If you work in international development? If you are interested in learning more about the history and evolution of the thinking driving international cooperation. This is a site for you.

      The site offers the pre-print version of an IDRC publication entitled International Development: Ideas, Experience, and Prospects, edited by Bruce Currie-Alder, Ravi Kanbur, David M. Malone, and Rohinton Medhora.

      This is an interesting book brings together the voices of over ninety authors, which include international development practitioners, experts and policy makers.

      The site contains a study guide comprised by eight sections of the book, each with a number of chapters. Ideal to use for beginner or advanced courses in universities and as reference for day to day work in the field.

  29. May 2016
    1. kids are led to believe all the marketing and advertising on TV,

      Is it just the kids? What role do teachers, doctors, and parents play? And older siblings?

    1. that doesn't mean the drugs can't be immensely profitable. Treanda is an orphan drug but also Teva's second-best seller, racking up $740 million in sales last year, according to Teva's annual report.

      Isn't the whole point of an orphan drug classification that of limited commercial viability? So if they're not commercially viable how are they profitable?

    1. Then, as the Sun of Know-ing begins to rise on the horizon of your consciousness;Then, will you feel the swell of a wondrous strange Breath filling you to the extreme of all yourmortal members, causing your senses almost to burst with the ecstasy of it; then, will there comesurge after surge of a mighty, resistless Power rising within you, lifting you almost off the Earth;then, will you feel within the Glory, the Holiness, the Majesty of My Presence;And then, then you will KNOW, I AM, God.You, -- when you have felt Me thus in such moments within, when you have tasted of MyPower, hearkened to My Wisdom, and know the ecstasy of My all-embracing Love, -- no diseasecan touch, no circumstance can weaken, no enemy can conquer you. For now you KNOW I AMwithin, and you always hereafter will turn to Me in your need, putting all your trust in Me, andallowing Me to manifest My Will.You, when you turn thus to Me, will always find Me an unfailing and ever present help in timeof need; for I will so fill you with a Realization of My Presence and of My Power, that you needonly Be Still and allow Me to do whatever you want done -- heal your ills and those of others,illumine your mind so you can see with My eyes the Truth you seek, or perform perfectly thetasks which before seemed almost impossible of accomplishmen

      To come to truly Know that God is within me, to Know it as a felt Reality............ And in all and every circumstances turn within to Me... turn to God and trust that support will unfailing...

  30. Apr 2016
  31. Feb 2016
  32. Jan 2016
    1. Getting and staying healthy involves tending to the people-oriented aspects of leading an organization, so it may sound “fluffy” to hard-nosed executives raised on managing by the numbers. But make no mistake: cultivating health is hard work. And it shouldn’t be confused with other people-related management concepts, such as employee satisfaction or employee engagement.

      I am looking forward to what these authors will provide as a recipe for cultivating health, and how they define organizational health.

  33. Nov 2015
    1. They have helped people reduce chronic pain, improve psoriasis, and increase their immune response to the flu shot. One study of mindfulness/compassion meditation out of Emory University showed reductions in stress markers, and even a simple long exhale (ahhhh) increases vagal tone. And – last but not least – a three-month meditation training program boosted telomerase activity, indicating longer telemores and perhaps a longer life expectancy.
    1. Experiments on humans have found that laughter can increase blood flow and strengthen the heart, much like aerobic exercise does. Laughter also helps decrease one’s threshold for pain, although not all humor is the same in this respect. According to Weems, positive humor—humor that looks for the bright side of troubling situations—is beneficial to our health, while darker, sardonic humor is not.
    2. laughing, probably through its effects on breathingwhich makes you breathe more deeply, actually calms your cardiovascular system. So, it reallyseems to be altering your stress profile as a pathway to physical health.
    3. Hirosaki, for example, has found in a review that bursts of laughterdecrease blood pressure, they enhance your immune function. In certain contexts, for example,when combined with exercise, they will reduce levels of chronic pain. They will improvethe physical health of elderly populations. Other studies by Ko, for example, find laughterimproves depressive symptomatology, how well elderly patients are sleeping.
    1. PAUL: Thank you. How does Substance relate to health? RAJ: Health is the constituting Wholeness of Being, the Orderliness, Integrity, Indivisibility and, therefore, the Perfection of all Conscious Being. Being omnipotent in Its ability to fulfill Its Intent or Purpose, there is no delay or obstacle to that fulfillment. It is this unimpeded Omnipresencing of Substance which constitutes Supply in what is called health or Wholeness.

      "Health is the constituting Wholeness of Being, the Orderliness, Integrity, Indivisibility and, therefore, the Perfection of all Conscious Being."

      "Being omnipotent in Its ability to fulfill Its Intent or Purpose, there is no delay or obstacle to that fulfillment. It is this unimpeded Omnipresencing of Substance which constitutes Supply in what is called health or Wholeness."

    1. In answer to why awe would be a potent predictor of reduced pro-inflammatory cytokines, this latest study posits that “awe is associated with curiosity and a desire to explore, suggesting antithetical behavioral responses to those found during inflammation, where individuals typically withdraw from others in their environment,” Stellar said.
    2. In addition to autoimmune diseases, elevated cytokines have been tied to depression. One recent study found that depressed patients had higher levels of the pro-inflammatory cytokine known as TNF-alpha than their non-depressed counterparts. It is believed that by signaling the brain to produce inflammatory molecules, cytokines can block key hormones and neurotransmitters—such as serotonin and dopamine—that control moods, appetite, sleep and memory.
    3. There are new psychophysiological findings finding that cytokine levels, cytokinesreally reflect an inflammation in response in your body, which is very tough news onyour health, the only positive emotion that really lowers levels of cytokines is provingto be awe.
  34. courses.edx.org