19 Matching Annotations
  1. Oct 2020
    1. Cessation of nitrous oxide resulted in characteristic convulsions similar to those seen in alcohol withdrawal in all mice.

      This demonstrates that tolerance is possible. However, exposure in humans lasts only several minutes at a time. Let's assume 3 exposures per day lasting 10 minutes each (i.e. 30 minutes total). It would take 68 days to reach 34 hours of exposure. Alternatively, that's a ratio of 1 to 47 exposure to non-exposure. It's unclear whether that would be sufficient for tolerance.

      In the 50% exposure group, convulsion score was effectively zero by hour 6 (from full text). This does not mean that withdrawal symptoms were gone. However, it does imply that recovery is rapid. It seems plausible that 20 hours between doses is sufficient to reach baseline, rendering tolerance in humans extremely unlikely. I will need to compare to alcohol withdrawal to confirm.

      Edit: Alcohol withdrawal in mice can be induced with 72 hours of alcohol exposure. That implies it is similar to NO. In humans, "the shakes" appear to last 1 or two weeks. In mice, convulsions appear to be half gone in 25 hours, suggesting that they last a few days. Thus, it appears that NO withdrawal is possibly an order of magnitude shorter than alcohol withdrawal.

      In conclusion, NO used in a normal fashion is unlikely to be harmful (except for risk of inducing B12 deficiency). Even if it is harmful, the short half life means that it will be apparent very quickly. I'm aware of several reports of B12 deficiency from NO abuse, but I haven't seen any reports of withdrawal symptoms.

  2. Aug 2020
    1. The straightforward solution to integrate WPML with third party translation services was to do it via dedicated plugins. A separate plugin for each company offering translation services could do the trick. However, this approach had a few drawbacks. For example, WPML developers would need to update and test all these plugins whenever the WPML core plugins received an update, and vice versa; when the API used by the external service changed, you needed to incorporate the change to WPML and test it as well.
  3. Jul 2020
    1. If you have worked with emails before, the idea of placing a script into an email may set off alarm bells in your head! Rest assured, email providers who support AMP emails enforce fierce security checks that only allow vetted AMP scripts to run in their clients. This enables dynamic and interactive features to run directly in the recipients mailboxes with no security vulnerabilities! Read more about the required markup for AMP Emails here.
  4. Jun 2020
  5. May 2020
    1. Myers, K. R., Tham, W. Y., Yin, Y., Cohodes, N., Thursby, J. G., Thursby, M. C., Schiffer, P. E., Walsh, J. T., Lakhani, K. R., & Wang, D. (2020). Quantifying the Immediate Effects of the COVID-19 Pandemic on Scientists. ArXiv:2005.11358 [Physics]. http://arxiv.org/abs/2005.11358

    1. Free data-driven attribution model Use Google’s advanced machine learning to more accurately distribute credit to all ad clicks that led to a conversion

      In other words, "just trust us" to magically figure it all out.

      I'd trust you more if you explained more about how do it. Maybe if I clicked "Learn more"?

    1. The "'strict-dynamic'" source expression aims to make Content Security Policy simpler to deploy for existing applications who have a high degree of confidence in the scripts they load directly, but low confidence in their ability to provide a reasonable list of resources to load up front.
  6. Apr 2020
    1. There is MiniKeePass on the iOS App Store, but I'm not sure if I trust it not to make off with my data. Also, syncing between my PC and the app would be a pain. (1Password has local WiFi sync) There is also KeeFox for Firefox integration, but I'm not sure if I trust that either. In short, I trust KeePass itself, but I'm not sure if I can trust the third-party developers of the mobile app and browser extension.
  7. Mar 2020
  8. www.graphitedocs.com www.graphitedocs.com
    1. Own Your Encryption KeysYou would never trust a company to keep a record of your password for use anytime they want. Why would you do that with your encryption keys? With Graphite, you don't have to. You own and manage your keys so only YOU can decrypt your content.
    1. Please consider that using this method means that you do not directly block the vendor scripts yourself, therefore, the success of this method depends heavily on the individual vendors’ adherence to regulation.
  9. Dec 2019
    1. Magnesium reduces the intensity of addiction to opiates and psychostimulants (cocaine, amphetamine, nicotine, and others). It also decreases the auto-administration of cocaine and the relapse into cocaine and amphetamine intake, as well as reducing the experimental addiction to morphine, cocaine and other substances in animals. In heroin addicts, alcohol consumers and other drug abusers, the plasma and intracellular magnesium concentration is lower compared to healthy subjects.

      Precisely what I'd expect. However, I was hoping to find a placebo controlled trial. I'm nearly certain that magnesium will show benefit. I'm less confident that such studies will use adequate doses of magnesium for the effects to reach statistical significance.

  10. Jul 2019
    1. Path FormationPaved paths are not always the most desirable routes going from point A to point B. This may lead pedestrians to take short-cuts. Initially pedestrians walk over green grass. Subsequent people tend to use the stamped grass path instead of the pristine grass, and after many pedestrians an unpaved path is formed without any top-down design.