12 Matching Annotations
  1. Oct 2020
    1. Cessation of nitrous oxide resulted in characteristic convulsions similar to those seen in alcohol withdrawal in all mice.

      This demonstrates that tolerance is possible. However, exposure in humans lasts only several minutes at a time. Let's assume 3 exposures per day lasting 10 minutes each (i.e. 30 minutes total). It would take 68 days to reach 34 hours of exposure. Alternatively, that's a ratio of 1 to 47 exposure to non-exposure. It's unclear whether that would be sufficient for tolerance.

      In the 50% exposure group, convulsion score was effectively zero by hour 6 (from full text). This does not mean that withdrawal symptoms were gone. However, it does imply that recovery is rapid. It seems plausible that 20 hours between doses is sufficient to reach baseline, rendering tolerance in humans extremely unlikely. I will need to compare to alcohol withdrawal to confirm.

      Edit: Alcohol withdrawal in mice can be induced with 72 hours of alcohol exposure. That implies it is similar to NO. In humans, "the shakes" appear to last 1 or two weeks. In mice, convulsions appear to be half gone in 25 hours, suggesting that they last a few days. Thus, it appears that NO withdrawal is possibly an order of magnitude shorter than alcohol withdrawal.

      In conclusion, NO used in a normal fashion is unlikely to be harmful (except for risk of inducing B12 deficiency). Even if it is harmful, the short half life means that it will be apparent very quickly. I'm aware of several reports of B12 deficiency from NO abuse, but I haven't seen any reports of withdrawal symptoms.

  2. Jun 2020
  3. May 2020
    1. So what’s the difference between returning a product on the grounds of withdrawal and returning it on the grounds of a guarantee?
    2. You don’t need to have any reason for exercising this right — you can simply change your mind
  4. Feb 2018
  5. Jan 2016
    1. Raj: Now, we are back to the feeling of the need for relief, aren’t we, Paul? Which simply means you feel a need to withdraw. We may stop talking in this fashion, but you don’t have to stop checking to see if I am here, and listening for my response. Just notice the feeling of the need for withdrawal into privateness—without judgment. But be aware of it. I will tell you that you can tolerate the active connection longer, and I want you to remember that the reason we are talking is because of your choice. It is not because I am forcing myself upon you. You do not need to withdraw from me. That is the excuse, but the excuse can only make sense if you can be distracted from the fact that you reached out for the connection. You are not, in fact, withdrawing from my embrace of you. You are withdrawing into privateness that does not allow you to experience the fact that you are embracing always! The suggestion is that you are shutting me out. But know that you are shutting yourself in—self-protective withdrawal into isolation for security that doesn’t constitute security, but which constitutes incarceration.

      "Just notice the feeling of the need for withdrawal into privateness—without judgement. But be aware of it."

      Feeling what we feel without judging it.

      "You are withdrawing into privateness that does not allow you to experience the fact that you are embracing always! The suggestion is that you are shutting me out. But know that you are shutting yourself in—self-protective withdrawal into isolation for security that doesn't constitute security, but which constitutes incarceration."