2 Matching Annotations
  1. Aug 2021
    1. withdrawal conditions

      Oddly, the strong adenosinergic pressure from ~20 hours wake combined from caffeine withdrawal didn't lead to increased SWS. Indeed, there was a nonsignificant trend towards a decrease in SWS. One possibility is that caffeine induced SWS surplus accumulation over the previous week, reducing SWS drive. However, this could alternatively be explained by the 60 minute nap.

      Withdrawal restored REM sleep under these conditions. The withdrawal condition looks quite similar to placebo (both REM and SWS), which is rather surprising.

  2. Sep 2018
    1. Ritanserin, 5 mg, produced a substantially larger increase in SWS (51.4%) than either ketanserin, 20 mg (17.2%) or ketanserin, 40 mg (24.4%). Ritanserin has a significantly higher affinity than ketanserin for 5-HT2C receptor binding sites in the human brain and, based on estimates of per cent occupancy by the two compounds at brain 5-HT2A and 5-HT2C receptors, we conclude that SWS in humans is primarily regulated by 5-HT2C receptors.

      This doesn't quite clarify the effect of 5HT2C antagonism in the absence of 5HT2A antagonism.