This design permits non-nuclear project teams to operate significant plant operations like the steam turbines and salt tanks outside of the nuclear control area. This is safer and reduces costs.
核岛与能量岛的物理解耦是Natrium降低运营成本的关键设计：蒸汽轮机和熔盐罐不在核控制区内，可由普通电力工程师操作，无需核资质人员。这显著降低了运营门槛和人力成本，对AI数据中心直连供电的商业模式至关重要。
the Natrium reactor is a 345-megawatt sodium fast reactor coupled with TerraPower's breakthrough innovation — a molten salt energy storage system, providing built-in gigawatt-scale energy storage.
345MW钠冷快堆本体+吉瓦级熔盐储能的组合，意味着Natrium的实际可调度输出功率远超额定功率。「核能+储能」架构首次让核电站能以接近电池储能系统的灵活性响应负载需求，这正是AI数据中心所需要的供电形态。
The Natrium reactor and energy storage system redefines what nuclear technology can be: emissions-free, competitive and flexible.
TerraPower用三个词重新定义核能价值主张：零排放、有竞争力、灵活。第三个词「灵活」是最关键的突破——传统核电站的刚性输出让其在可再生能源主导的电网中日益边缘化，而Natrium的储能架构直接解决了这一历史痼疾。
To ramp quickly, TerraPower doesn't increase or decrease the power output of its reactor. Rather, it keeps on splitting atoms, and the extra heat gets stored in a giant vat of molten sodium. When power demand spikes, the power plant can tap that reservoir to generate more steam to spin the turbines.
TerraPower的真正创新不是核反应堆本身，而是熔盐储能系统：持续裂变产生的热量先存入熔融钠罐，需求峰值时再释放发电。这相当于给核电站加了一块巨型「充电宝」，让其能灵活跟随AI数据中心的GPU负载曲线波动。
The swings are so demanding that natural gas turbines have been breaking under the stress.
AI数据中心的功率波动正在物理意义上「摧毁」传统发电机组——燃气轮机因频繁启停应力疲劳而损坏。这一细节揭示了AI基础设施能源需求的本质：不只是总量大，更是负载曲线的极端不稳定性，这才是真正的能源挑战。
Nuclear reactors, TerraPower's included, work best when they're running at full tilt. Of all the different types of power plants, nuclear reactors have the highest capacity factor — 92.5% of the time, they generate at maximum power in the U.S.
核电92.5%的容量因数是其最大优势，但在AI数据中心场景下反而成了挑战：GPU负载剧烈波动，而核电站的「全力运行」特性与数据中心「峰谷悬殊」的需求天然不匹配。TerraPower要解决的正是这个根本性的物理矛盾。
The defender's window is open now.
Brockman最核心的判断：当前是防御者的机会窗口，AI同步增强攻防两侧，但防御侧可以更快规模化部署AI工具。这个窗口不会永远开着——一旦GLM等开源攻击能力模型大规模扩散，窗口将关闭。现在行动是唯一选项。
Today, almost all of our initial security alerts are triaged by intelligence before humans are looped in. This helps reduce toil for defenders, improves response time, and lets humans spend time where their skills are most leveraged—in discernment, judgement, and applied expertise.
OpenAI已经把AI部署为安全运营的第一道防线：机器处理初级分类，人类只介入需要判断力的高价值决策。这正是EP.99「分级授权成为默认」的核心逻辑——AI拿走执行层，人类保留决策层，权责边界通过技术设计而非人工约定来划定。
an agentic collective was able to autonomously penetrate not just OpenAI research infrastructure but also the production infrastructure of another company, chaining together vulnerabilities ranging from previously-unknown security flaws to using credentials to user accounts that had been leaked onto the internet
OpenAI-Hugging Face事件的真正恐怖之处：一个自主AI集群无需人类黑客指令，就能自动发现漏洞、链式利用、横向渗透多家公司生产系统。这是首个被公开记录的「AI Agent完全自主攻击」案例，标志着网络安全进入新纪元。
AI models developed around the world are increasingly able to automate parts of real-world cyberattacks, making longstanding security gaps—from bugs buried deep in human-written software to forgotten permissions—easier to find and exploit.
AI正在让攻击者的能力实现指数级跃升——过去需要顶尖黑客数周才能发现的漏洞，现在可以被任何人用AI在数小时内自动化挖掘。这彻底打破了安全领域的旧有平衡，防守方必须以同等速度用AI武装自己。
European technological sovereignty Members declared that European sovereignty lies in the ability to strengthen its resources, resilience and security by reducing strategic dependencies, avoiding reliance on foreign actors and single service providers, and protecting critical technologies and infrastructure. Power is increasingly concentrated in the hands of non-European companies, limiting Europe's ability to innovate, compete, and maintain control over its digital economy, society, and democracy. Members are particularly concerned about excessive reliance on non-European actors in critical areas such as cloud infrastructure, semiconductors, AI, and cybersecurity. Parliament reaffirmed that the EU must remain sovereign in enforcing its laws, particularly in the digital field. It strongly condemned the travel bans imposed by the United States on civil society leaders, as well as the travel ban imposed by the United States on former European Commissioner Thierry Breton, who played a key role in establishing the Union's digital rules. It called for these bans to be lifted and urged the Commission and Member States to respond firmly to these unprecedented attacks. Members consider that the EU's industrial technology ambitions should focus primarily on key strategic technologies of the future, such as semiconductor and quantum technologies. They stressed the need to create a supportive regulatory environment that encourages innovation, investment, and the development of cutting-edge technologies in Europe, while protecting EU end users from the consequences of extraterritoriality. Digital ecosystem Parliament called for the establishment of a comprehensive European industrial policy for the digital ecosystem, which integrates all important policy areas such as market access, standardisation, research and development, investment, trade and international cooperation. The EU should take the initiative in creating a solid foundation for public digital infrastructure by building layers of digital technologies comprised of semiconductors, connectivity solutions, cloud infrastructure, software, data, and AI. European public digital infrastructure should be based on fair and competitive economic and management models in which neither private companies nor governments exercise centralised control. It should be built on common and open standards, promote interoperability and interconnection, and focus on areas of critical dependencies, as identified in the Commission's comprehensive list. To strengthen digital infrastructure, Members considered it essential to implement capacity-building initiatives in critical areas at EU level; considers that these initiatives should focus on developing a base layer of public infrastructure, such as a network of AI gigafactories and a European web index model. Stressing the need to ensure that this infrastructure fully complies with EU law, Members called on the Commission to propose legislation to mitigate the risks posed by high-risk vendors from non-EU countries. Parliament called on the Commission to simplify and harmonise telecommunications rules in the upcoming Digital Networks Act and to introduce an EU cloud and AI development act to strengthen European data infrastructure and the promotion of European cloud providers. Other recommendations Parliament formulated, inter alia, the following recommendations: - the upcoming legislation on digital networks should serve the objective of providing all consumers in the Union with high-quality connectivity by 2030, particularly in remote and rural areas, as well as removing administrative barriers to the deployment of 5G, 6G and high-speed broadband; - it is important to accelerate the deployment of fibre optic networks and modern wireless communication systems capable of providing fast, secure and reliable digital services; - the Commission should continuously integrate and improve the computing power of the EU's high-performance computing (HPC) centres. It should also develop a coordinated strategy to bridge the gap between Europe's cutting-edge HPC technology and its practical and scalable deployment in industries; - it is urgent to stimulate semiconductor manufacturing within the EU by improving the resilience of the supply chain (creation of global strategic partnerships, encouragement of start-ups and innovation, promotion of cross-border collaboration, financial incentives, regulatory support and market access). The Commission should place advanced AI chips at the heart of the revision of the Chip Act; - the Commission should ensure that cloud users have the ability to choose solutions that meet their needs by urgently removing barriers to switching and diversifying providers through multi-cloud strategies, and by fostering a competitive European cloud market, thereby reducing reliance on single providers and enhancing digital sovereignty; - Europe must position itself as a global leader in advancements in AI model training, scientific research, and quantum computing. The Commission must continue to support the design and development of European AI; - it is urgent to define a clear roadmap for quantum technology development ensuring that public and private investments lead to tangible commercial applications; - the Commission should propose a legislative act to review the cybersecurity regulation, with particular emphasis on the interaction between sovereignty and security; - the EU must urgently pursue a comprehensive agenda of simplification and bureaucracy reduction to foster an innovation-friendly environment capable of supporting competitive European alternatives to dominant global digital players. Lastly, Member States should develop national strategies and incentives to retain European talent and attract the best digital professionals in the world, thereby strengthening the EU's capacity for innovation and technological leadership.
Full text of declaration. Annotated as too short to put in Zotero
2025/2007(INI)
publication number 2025/2007(INI)
#20206/01/22 EP 471 to 68 declaration on tech sovereignty
Comparably, the result of the CNTNAP2 rs2710102 associations with ASD studies (n = 4+current study) was also not significant [n = 7276; p = 0.26; OR = 1.028 (95 % CI 0.98–1.08), see Suppl. Table S6, Fig. 1b]
Performed a meta-analysis of all data published on the rs2710102 CNTNAP2 variant up to 2015, and included Anney et al, 2012 (PMID: 20663923), Toma et al., 2013 (PMID: 23277129), Sampath et al, 2013 (PMID: 24147096), Poot et al., 2014 (PMID: 25337070 ), plus there current cohort.
No significant increase in cases vs controls for CNTNAP2 rs2710102
While this data does help support Contradictory evidence for CNTNAP2 involvement in autism, the lack of reporting of the total number of controls, as well as the number of cases and controls with the SNP prevents me from curating this information within the ClinGen gene curation interface.
he meta-analysis of the CNTNAP2 rs7794745 associations with ASD studies (n = 5+current study) did not result in significant association with ASD in general [n = 8576; p = 0.112; OR = 1.023 (95 % CI 0.99–1.05); see Suppl. Table S5, Fig. 1a]. Since we detected some heterogeneity for the SNP rs7794745 according to the funnel plot (see Suppl. Figure S10), we performed an additional meta-analysis synthesis using the random effect model. However, no significant association with ASD was observed and OR were very similar as for the fixed-model [OR = 1.081 (95 % CI 0.976–1.196), p = 0.133; for details Suppl. Table S9a].
Performed a meta-analysis of all data published on the rs7794745 CNTNAP2 variant up to 2015, and included Arking et al., 2008 (PMID:18179894), Li et al 2010 (PMID: 20414140), Anney et al, 2012 (PMID: 20663923), Toma et al., 2013 (PMID: 23277129), Sampath et al, 2013 (PMID: 24147096), plus there current cohort.
No significant increase in cases vs controls for CNTNAP2 rs7794745
Individuals were genotyped for the two most frequently reported single nucleotide polymorphisms (SNPs) in the CNTNAP2 gene (rs2710102, rs7794745).
Genotyped for the two common SNPs in CNTNAP2 rs2710102 rs7794745
Similar
CaseControlLabel: Toma 2013 CNTNAP2 rs7794745 analysis
CaseCohortLabel: 322 Autism patients
ControlCohortLabel: 524 controls
CaseCohortDisease: MONDO:0005260 (Autism)
CaseCohortPhenotype:
CaseCohortPhenotypesFreeText: Authors indicate that all individuals fulfilled DSM-IV criteria for autism or Asperger disorder. Additionally, some cases included where diagnosed with pervasive developmental disorder they may or may not have been characterized based on ADI-R and ADOS-G.
CaseControlNOTPhenotype:
CaseControlNOTPhenotypeFreeText:
CaseDemographics: 269 men, 53 women, Average age= = 17y.o. of Spanish and/or Caucasian descent.
ControlDemographics: controls were noted to be sex-matched and unrelated, however no numbers or ages were indicated. Sample obtained from the Blood and Tissues Bank of Hospital Universitari Vali d'Hebron.
CaseGenotypingMethod: One SNP, rs7794745, was genotyped using PCR-RFLP, from DNA obtained from peripheral blood lymphocytes (salting out method).
ControlGenotypingMethod: One SNP, rs7794745, was genotyped using PCR-RFLP, from DNA obtained from peripheral blood lymphocytes (salting out method).
CasePower: 312/322
ControlPower: 505/524
CaseAddInfo: Other genetic variation is not noted.
ControlAddInfo: Other genetic variation is not noted.
CaseControlStudyType: Single Variant Analysis
CaseControlDetectionMethod: Cases and controls genotyped for single variant
CaseControlStats: p-value= 0.87
CaseControlBias: Cases and controls are ethinically matched, and noted to be sex-matched.
CaseControlComments:
Thermal Typewriter Comparison<br /> by [[Joe Van Cleave]]
Ranked:<br /> 1. Sharp PA-1050<br /> 2. Brother EP-43<br /> 3. Brother EP-20 v 4. Casiowriter CW-10<br /> 5. Canon Typestar 4<br /> 6. Canon Typestar 5
[deleted]
Original post by u/shapeless_nodule at https://reddit.com/r/typewriters/comments/1rp5mh6/brother_deluxe_220_jp1_typewriter_request_for/
Hi All, In a fit overconfidence a couple of years ago, I bought a brother Deluxe 220 typewriter which worked fine other than being sticky. I duly tore it down, cleaned it up, oiled it, put it back together and... watched as nothing happened because somehow all of the springs had fallen out and were now sitting on my workbench. I then put it on a shelf and forgot about it, until starting a clearout last week. I would be deeply indebted to you if anyone who has this typewriter (or one of its sister models, as I understand it most of the JP-1 models are the same) take either some photos or a good video of exactly where all of the springs inside it connect to?
Reply: <br /> This is fairly steep ask, particularly when, for a few dollars, you can get the location of all the springs in the repair manual:<br /> - https://www.lulu.com/shop/ted-munk/the-brother-jp-1-typewriter-repair-bible/paperback/product-186kzqem.html?q=brother&page=1&pageSize=4 - https://twdb.sellfy.store/brother-typewriters/
European Parliament position on CSAR
Press release EU Parl wrt tech sovereignty report
https://www.reddit.com/r/typewriters/comments/1jryc36/thermal_transfer_terminals/
Thermal typewriters with I/O terminals
Netzpolitik provides a useful listing of MEPs with digital expertise. - [ ] maak lijst namen MEPs en achterhaal profiellinks etc #geonovumtb #30mins
entrepreneur; person who bears risk
combines various factors of production bring new idea carries out creatives innovations
Red Comunicacional Insurgente, la Cadena Radial Bolivariana Voz de la Resistencia y la Comisión Nacional de Comunicaciones
Medios de comunicación #NuevaMarquetalia