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    <Emphasis Type="Italic">CNTNAP2</Emphasis> gene in high functioning autism: no association according to family and meta-analysis approaches
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    1. Vibhor 09 Jul 2026
      Comparably, the result of the CNTNAP2 rs2710102 associations with ASD studies (n = 4+current study) was also not significant [n = 7276; p = 0.26; OR = 1.028 (95 % CI 0.98–1.08), see Suppl. Table S6, Fig. 1b]

      Performed a meta-analysis of all data published on the rs2710102 CNTNAP2 variant up to 2015, and included Anney et al, 2012 (PMID: 20663923), Toma et al., 2013 (PMID: 23277129), Sampath et al, 2013 (PMID: 24147096), Poot et al., 2014 (PMID: 25337070 ), plus there current cohort.

      No significant increase in cases vs controls for CNTNAP2 rs2710102

      While this data does help support Contradictory evidence for CNTNAP2 involvement in autism, the lack of reporting of the total number of controls, as well as the number of cases and controls with the SNP prevents me from curating this information within the ClinGen gene curation interface.

      PreviouslyPublished ContradictoryEvidence gene:CNTNAP2 ClinGen ID/Autism EP hgnc_imputed:rsID
    2. Vibhor 09 Jul 2026
      he meta-analysis of the CNTNAP2 rs7794745 associations with ASD studies (n = 5+current study) did not result in significant association with ASD in general [n = 8576; p = 0.112; OR = 1.023 (95 % CI 0.99–1.05); see Suppl. Table S5, Fig. 1a]. Since we detected some heterogeneity for the SNP rs7794745 according to the funnel plot (see Suppl. Figure S10), we performed an additional meta-analysis synthesis using the random effect model. However, no significant association with ASD was observed and OR were very similar as for the fixed-model [OR = 1.081 (95 % CI 0.976–1.196), p = 0.133; for details Suppl. Table S9a].

      Performed a meta-analysis of all data published on the rs7794745 CNTNAP2 variant up to 2015, and included Arking et al., 2008 (PMID:18179894), Li et al 2010 (PMID: 20414140), Anney et al, 2012 (PMID: 20663923), Toma et al., 2013 (PMID: 23277129), Sampath et al, 2013 (PMID: 24147096), plus there current cohort.

      No significant increase in cases vs controls for CNTNAP2 rs7794745

      PreviouslyPublished ContradictoryEvidence gene:CNTNAP2 ClinGen ID/Autism EP hgnc_imputed:rsID
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    link.springer.com/article/10.1007/s00702-015-1458-5