for - quote - liberal woman dated conservative men - He clearly had no idea he was out with someone he once threatened to kill.

for - quote - air is a resource so vast has no value in the economy - David Suzuki

Review coordinated by Life Science Editors Foundation Reviewed by: Dr. Angela Andersen, Life Science Editors Foundation & Life Science Editors Potential Conflicts of Interest: None

PUNCHLINE This preprint reveals a novel mechanism by which nitric oxide (NO) regulates lipid uptake in endothelial cells through nitrosation of the fatty acid transporter CD36. In conditions where endothelial NO is elevated, CD36 is modified at key cysteine residues, which prevents its localization to the plasma membrane and thus inhibits lipid uptake. This nitrosation-based regulation protects endothelial cells from lipid overload while increasing circulating serum lipids. The findings establish a dynamic and reversible regulatory axis—Cav1 → NO → CD36—that links vascular signaling to metabolic control.

BACKGROUND Endothelial cells (ECs), which line the blood vessels, are uniquely positioned as gatekeepers of metabolic exchange—controlling the delivery of nutrients, including fatty acids, from the bloodstream into peripheral tissues. In the setting of metabolic syndrome, a state of chronic nutrient excess, this finely tuned lipid transport system becomes dysregulated. Excessive lipid uptake by ECs leads to lipid accumulation, mitochondrial dysfunction, and progressive endothelial impairment, which in turn contributes to the pathogenesis of cardiovascular and metabolic diseases.

While ECs appear to possess intrinsic protective mechanisms to buffer against lipid overload, the molecular basis of these protective responses is poorly understood. The authors sought to uncover how ECs might actively limit lipid uptake under stress, and what upstream signals trigger this protective state.

QUESTIONS ADDRESSED How do endothelial cells protect themselves from lipid-induced dysfunction during nutrient excess? What regulatory mechanisms allow them to limit lipid uptake under stress?

SUMMARY Reduced endothelial Cav1 leads to increased NO production and, in turn, nitrosation of CD36. This modification prevents CD36 from reaching the plasma membrane, blocking lipid uptake into ECs. As a result, circulating serum lipids increase, but endothelial function is preserved. These findings define NO-mediated nitrosation as a new mechanism of post-translational regulation of CD36, with implications for endothelial health in metabolic disease.

KEY RESULTS Cav1 is downregulated in endothelial cells in obesity Figures 1A–F, Supplementary Fig. 1A–F Goal: Identify genes affected by obesity that regulate endothelial lipid uptake. Outcome: Single-cell RNA-seq of mouse and human adipose tissues reveals consistent downregulation of Cav1 in all endothelial subtypes during obesity (Fig. 1A–F). Supplementary Fig. 1 shows quality control, cell-type identification, and confirmation of downregulated Cav1 expression in both species (Supp. Fig. 1A–F).

Loss of Cav1 increases circulating lipids and decreases EC lipid uptake Figures 2A–K, Supplementary Fig. 2A–E Goal: Determine the physiological effect of Cav1 loss on lipid homeostasis. Outcome: EC-specific Cav1 knockout mice have elevated serum triglycerides, cholesterol, and LDL (Fig. 2E–G), but reduced lipid droplet accumulation in ECs (Fig. 2J). They maintain normal weight and show improved glucose tolerance (Fig. 2H–L). Supplementary Fig. 2 confirms successful endothelial deletion of Cav1 (Supp. Fig. 2A–C) and shows that hyperlipidemia is not due to differences in dietary intake or lipid absorption (Supp. Fig. 2D–E).

Loss of Cav1 elevates NO and suppresses lipid uptake Figures 3A–J, 4A–F, Supplementary Fig. 3A–E Goal: Test whether elevated NO mediates lipid uptake defects. Outcome: Cav1 knockout increases serum nitrate/nitrite (Fig. 3J), reflecting elevated NO. Pharmacologic NO inhibition with L-NAME restores lipid uptake in HAMECs (Fig. 4A) and mouse aorta (Fig. 4B), and reduces serum lipids (Fig. 4C–D). Deletion of eNOS in ECs—but not in RBCs—rescues the phenotype (Fig. 4E–F). Supplementary Fig. 3 shows that Cav1 knockout does not impair vasodilatory responses to acetylcholine and confirms NO elevation by multiple readouts (Supp. Fig. 3A–E).

CD36 mediates endothelial lipid uptake and is regulated by NO Figures 5A–F, Supplementary Fig. 4A–D Goal: Identify whether CD36 is necessary and sufficient for NO-regulated lipid uptake. Outcome: CD36 localizes to Cav1-enriched domains (Fig. 5A) and is required for lipid uptake (Fig. 5C). NO donors suppress CD36-mediated lipid uptake in HEK293T cells (Fig. 5D), and NO induces CD36 nitrosation (Fig. 5E). Pharmacologic CD36 inhibition abolishes the effect of eNOS deletion (Fig. 5F). Supplementary Fig. 4 confirms that CD36 expression is unaltered by NO or Cav1 loss, suggesting the effect is post-translational (Supp. Fig. 4A–D).

CD36 is nitrosated at cysteines 3 and 466, disrupting palmitoylation and lipid uptake Figures 6A–D, 7A–F, Supplementary Fig. 5A–C Goal: Identify the functional nitrosation sites and their impact on trafficking. Outcome: CD36 is nitrosated at C3 and C466. Mutating these residues abolishes nitrosation and restores lipid uptake despite NO exposure (Fig. 6C–D). Nitrosation prevents palmitoylation of CD36 (Fig. 7D), explaining the loss of plasma membrane localization (Fig. 7B–F). Supplementary Fig. 5 shows quantification of CD36 localization shifts (Supp. Fig. 5A–C).

Nitrosation restricts CD36 to the ER and blocks its trafficking Figures 7A–F, Supplementary Fig. 6A–D Goal: Understand the subcellular localization of nitrosated CD36. Outcome: In Cav1-deficient or NO-treated ECs, CD36 remains in the endoplasmic reticulum (ER) (Fig. 7B, 7E). L-NAME restores membrane localization (Fig. 7C, 7F). Supplementary Fig. 6 provides further co-localization data with ER and Golgi markers and quantifies trafficking defects (Supp. Fig. 6A–D).

NO protects ECs from lipid-induced mitochondrial dysfunction and impaired vasodilation Figures 8A–C, Supplementary Fig. 7A–E Goal: Determine the physiological consequence of NO-CD36 signaling. Outcome: Lipid exposure combined with L-NAME leads to mitochondrial dysfunction (Fig. 8A) and impaired vasodilation (Fig. 8C), both rescued by NO. Supplementary Fig. 7 shows full mitochondrial stress test profiles and validation of mitochondrial protein levels (Supp. Fig. 7A–E).

STRENGTHS Defines a novel mechanism linking Cav1, NO, and CD36 to lipid homeostasis

Broadens our understanding of endothelial metabolic self-regulation

Identifies post-translational nitrosation as a reversible toggle on lipid uptake

Uses elegant genetic models, in vivo functional assays, and biochemical rigor

Links vascular NO signaling to metabolic adaptation

Highly relevant to metabolic syndrome, lipedema, and vascular disease

FUTURE WORK & EXPERIMENTAL DIRECTIONS Investigate whether modulating CD36 nitrosation could be therapeutic in hyperlipidemia

Study whether this mechanism contributes to sex differences in metabolic disease

Explore its role in other vascular beds and tissue-specific lipid handling

Test implications for lipedema, a fat-distribution disorder involving endothelial dysfunction

Define how palmitoylation and nitrosation are balanced or dynamically regulated

AUTHORSHIP NOTE This review was drafted with the assistance of ChatGPT (OpenAI) to help organize and articulate key ideas clearly and concisely. I provided detailed prompts, interpretations, and edits to ensure the review reflects an expert understanding of the biology and the paper’s contributions. The final version has been reviewed and approved by me.

FINAL TAKEAWAY This preprint reframes endothelial cells as active regulators of systemic metabolism. By showing that nitrosation of CD36 suppresses lipid uptake and preserves endothelial function under metabolic stress, the authors reveal a previously unrecognized mechanism of cellular protection. This discovery expands our understanding of how ECs maintain homeostasis in nutrient-rich environments and opens new directions for treating lipid-associated diseases like obesity, lipedema, and atherosclerosis.

for - representative democracy is no longer fit for purpose

for - representative democracy is no longer for for purpose

Curioso por leer más en detalle. Particularme por la pregunta de si se pueden superar dichos binarismos heredados y colonizantes.

Valdría la pena problematizar estos binarios. ¿Pueden ser superados?

for - Guardian article - ‘Eugenics on steroids’: the toxic and contested legacy of Oxford’s Future of Humanity Institute - 2024, Apr 28. - longterminism - Future of Life Institute - had no future - from Guido Palazzo - article - From Übermensch to Uber-man - https://hyp.is/LuxHUOYCEe-m1JsgFH7ABQ/guidopalazzo.com/from-ubermensch-to-uber-man/

for - quote - occupy movement - occupy wallstreet - no strategy - Robert Reich

for - quote - there is no fundamental objectivity because the scientist is always bringing his or her own interests, perspectives, toolmaking and strategies and these in essence mold their questions that they can answer - SOURCE - interview - Youtube - channel: Brain Inspired - Episode: BI 186 Mazviita Chirmuuta: The Brain Abstracted - 2024, Mar

for - Youtube -Right way to eat sugar - No inflammation - health - diet - how to minimize insulin spike when eating sugar - Dr. Anshul Gupta M.D. 2024 Nov

summary - combine with protein or good faats to slow down sugar release - exercise 15 minutes after eating sugar - eat in the morning, not the evening - eat small portions - stevia and monkfruit are the only sugar substitutes

for - AI - progress trap - Youtube - bioweapons is not the only threat. Nano technology and many others can be turned into weapons of mass destruction - RDeepSeek R1 just caught up with OpenAIs o1 - There is no moat@ What does this mean? - David Shapiro - 2025, Jan 29

https://www.nytimes.com/2025/01/28/business/energy-environment/chevron-power-plant-ai.html

for - post - LinkedIn - misinformation - Meta joins Elon Musk and Twitter no moderation - 2025, Jan 8

for - Buddhism - Tibetan - Tukdam - ordinary people with no training also go into Tukdam - from Youtube - Between Life and Death: Understanding Tukdam - John D. Dunne

for - key insight - Buddhism - TIbetan - Clear light meditation - Tukdam at time of death - no longer capable of thinking, seeing, hearing, etc - all that's left is naked consciousness without even subject-object from Youtube - Between Life and Death: Understanding Tukdam - John D. Dunne

for - trivia - measuring tukdam after death - 24 hour period immediately following death is important but to date, no data captured - Youtube - Tukdam talk - An Overview Of CHM’s Work On “Well-Being And Tukdam” - Prof. Richard J. Davidson

for - quote - climate crisis - In 2024, temperatures soared above 1.5 Deg C. Have we breached the threshold? Yes and No - Kevin Anderson

quote - climate crisis - In 2024, temperatures soared above 1.5 Deg C. Have we breached the threshold? Yes and No - Kevin Anderson - (see below) - We hit it for one year and that doesn't tell us we've hit it or we haven't hit it - We we typically want to see a longer running average so we typically use n 11-year running average - so a single year doesn't tell us we've hit it or we haven't hit it - But it may well be that we're already in that long run average - We might be already one of those years that means we're not going to drop below 1.5

for - 2024 US election results - many Americans voted for down-ballot candidates but not national candidates - suggested no options available to voters - Otto Scharmer

for - key insight - quote - Why Harris lost US election - no perceived genuine alternative to BAU - Roger Hallam - from - Medium article - An Emerging Third Option: Reclaiming Democracy from Dark Money & Dark Tech Seven Observations On 2024 and What’s Next - Otto Scharmer - terminology - Status Quoism

key insight - quote - Why Harris lost US election - no perceived genuine alternative to BAU - Roger Hallam - (see below) - What the defeat of Harris shows about the US is this. People like everywhere else want a real alternative and - If there is no authentic left option, people vote for a fascist instead. - It happens again and again in history

from - Medium article - An Emerging Third Option: Reclaiming Democracy from Dark Money & Dark Tech Seven Observations On 2024 and What’s Next - Otto Scharmer - terminology - Status Quoism - https://hyp.is/Mxp1GqtFEe-pKzNGX6BrhQ/medium.com/presencing-institute-blog/an-emerging-third-option-reclaiming-democracy-from-dark-money-dark-tech-3886bcd0469b

for - capitalism is dead - permanent decline of American capitalism - have no more capacity - hollowed out and only good at capital accumulation - Yanis Varoufakis

for - quote - the Nation (state) is no longer able to force the State to regulate the Market - Michel Bauwens - climate crisis - transnational capitalism escapes the regulation of nation states - example - COP conferences and climate change

https://stationeryfestival.com/exhibitors

Elite Accessories<br /> 3428 Hauck Rd, Ste K<br /> Cincinnati, OH 45241<br /> (630) 945-2710

Represents the following stationery manufacturers in the US:<br /> - Kaweco (Germany) fountain pens - Kyo No Oto (Tag Stationery) inks - Oeda Letterpress (Osaka Japan) letterpress stationery - Onishi Seisakusho (fountain pens) - Diamine Inks (Liverpool, UK)

No Scrubs (Official HD Video) by [[TLC]]

TLC has ensconced the idea of not getting married or even dating if a man doesn't reach a level of financial security.

TRSP Desirable Characteristics The basic services of PID registration and resolution SHALL have no cost to end users.

TRSP Desirable Characteristics Ethical data are data that do not stigmatise or portray Indigenous Peoples, cultures, or knowledges in terms of deficit. Ethical data are collected and used in ways that align with Indigenous ethical frameworks and with rights affirmed in UNDRIP. Assessing ethical benefits and harms should be done from the perspective of the Indigenous Peoples, nations, or communities to whom the data relate

Thank you so much for creating the meeting and for holding space It is not intended that any one person ought to be a central point of contact We are to become autocatalytic - energies arise and fall and all that is is and all that is not is not Some people will not show up Some people will show up all the time We are all equally included We are all One

for - quote / critique - The price we pay for this salutary change is, no doubt, great - Andrew Carnegie

quote / critique - The price we pay for this salutary change is, no doubt, great - Andrew Carnegie - Carnegie goes on to write that the great freedoms offered by industrial mass production has an unavoidable price to be paid - Successful manufacturing and production cooperatives, B-Corporations, worker-owned companies, etc have disproved that it is an either-or situation. - Consider the case of the Spanish manufacturing giant, Mondragon, a federation of worker cooperatives employing 70,000 people located in Spain - where this price is NOT paid - Carnegie's essay reflects a perspective based on the time when he was alive - Were Carnegie alive today to witness the natural conclusion of his trend of progress in the Anthropocene, he would witness - extreme pollution levels of industrial mass production threatening to destabilize human civilization itself - astronomical wealth inequality - And these two are linked: - wealth inequality - a handful of elites have the same wealth as the bottom half of humanity - carbon inequality - that same handful pollutes as much as the bottom half of humanity

to - Mondragon cooperative - explore - https://hyp.is/GeIKao1rEe-9jA_97_KRBg/exploremondragon.com/en/ - Oxfam wealth and carbon inequality reports - https://jonudell.info/h/facet/?max=100&expanded=true&user=stopresetgo&exactTagSearch=true&any=oxfam

50:32 Currency is the governments I.O.U. 52:04 When the government gets its tax, it no longer has the debt so it burns the currency which was an I.O.U.

Irony in the "Alone at last", as she really hates it. She'd rather have Serena there, in all hypocrisy of her misery, she'd rather go through the ceremony -- in the end none is best, men are men, any sort of rape is uncomfortable for her. The men have not changed.

for stats - digital decay - twitter -20% of tweets are no longer publicly visible 0ne month later

for - stats - digital stats - 54% of Wikipedia pages contain at least one link in their “References” section that points to a page that no longer exists.

for stats - digital stats - 38% of webpages in 2013 no longer exist May 2024

for - stats - digital decay - 25% of webpages that existed from 2013 to 2023 no longer exist as of Oct 2023

stats - digital decay - A quarter of all webpages that existed at one point between 2013 and 2023 are no longer accessible as of October 2023

for - AI - progress trap - example - Facebook AI algorithm - target - increase user engagement - by spreading hateful conspiracy theories - AI did this autonomously - no morality - Yuval Noah Harari story

for - AI - progress trap - example - no morality - Open AI - GPT4 - could not solve captcha - so hired human at Task Rabbit to solve - Yuval Noah Harari story

for - stats - earth system boundary - biodiversity - human modified ecosystems -absolute minimum of 10% - below this, many of Nature's contribution to people would no longer be provided

Crazy happenings now maybe

Macey Filing Appliances 1906<br /> Catalogue No. 4206<br /> The Macey Co.<br /> https://archive.org/details/macey-filing-appliances-1906/mode/2up

for - quote - no cloning theorem - quantum mechanics - extended to consciousness and qualia - Frederico Faggin - hard problem of consciousness - no cloning theorem and private inner world of qualia - Frederico Faggin quote - no cloning theorem - quantum mechanics - extended to consciousness and qualia - Frederico Faggin - (see below) - What I feel what I feel is private. - What you feel is private. - You cannot transfer it to me - In order to tell you what I feel, I must translate that private feeling into classical information bit saying what I say. - The symbols must be this. - They must be sharable. - They must be copyable to share. You need to copy. Yeah. - My inner experience cannot be copied. And there is something in physics that cannot be copy. - In Quantum state, there is the "no cloning theorem", which says do not copy. - Not only that, but the maximum information that you can get if you make a measurement of the quantum state is one bit per quantum bit. - Olivas theorem says that and we have or Labor's theorem ourselves. What I can say about what I feel is much, much less

Dispõe sobre a instituição da Politica Municipal de Plantas Medicinais e Medicamentos Fitoterápicos e da outras providências.

Aunque el tabaquismo aumenta en forma significativa el riesgo de carcinoma broncógeno en trabajadores del asbesto y agrava la asbestosis, no existe una relación entre tabaquismo y mesotelioma.

for - comparison - cortical io / semantic folding vs standard AI - no GPU required

for - sustainable building - building reuse vs new build - which is better? - California Forever - intentional community - green debate

sustainable building - building reuse vs new build - which is better? - Study by Preservation Green Lab in 2012 concluded that in most cases, reusing existing buildings is far lower carbon footprint than building new - Research study shows that we cannot expand human activity into intact nature any longer if we are to stay within planetary boundaries - Rockstrom - https://hyp.is/0dbJ4FQSEe-QxY8q4Y3yvw/www.youtube.com/watch?v=JaboF3vAsZs

for - quote - Johan Rockstrom - 2024 - double frustration - allowing situation to deteriorate - while there is no sacrifice

for - neuroscience - education of children - recommend no digital devices before puberty - allows learning in a 3 dimensional world

for - neuroscience - efficient work - relaxation rule

neuroscience - efficient work - relaxation rule - It is necessary to build NO WORK time into effective work - 5 time units work - 1 time unit relaxation - It is necessary to step back from concentrating on a problem - for the brain to drift away from it and - relax from concentrating on the problem - so that new perspectives can develop that can be brought back to solve the problem

for - comparison - data vs ideas - no metric for ideas

for - governance - planetary subsidiary - no idea how to get there

for - key insight - farmed fish have no omega 3 because they eat corn, not algae

for - health - heart - need to identify those with high LDL but ARE metabolically healthy

health - heart - high LDL AND metabolically healthy - against medical norms, there may be NO NEED TO LOWER THEIR LDL levels - and in fact, trying to do so may lead to harm

for - political polarization - challenge to building multi-racial coalition - to - Wired story - No one actually knows how AI will affect jobs

political polarization - building multi-racial coalitions - This is challenging to do when there is so much political polarization with far-right pouring gasoline on the polarization fire and obscuring the issue - There is a complex combination of factors leading to the erosion of working class power

automation - erosion of the working class - Ai is only the latest form of the automation trend, further eroding the working class - But Ai is also beginning to erode white collar jobs

to - Wired story - No one actually knows how AI will affect jobs - https://hyp.is/KsIWPDzoEe-3rR-gufTfiQ/www.wired.com/story/ai-impact-on-work-mary-daly-interview/

"too apt for the purpose to resist" :kiss:

for - adjacency - symbolic language - no longer individual - parasitic on larger relationship - Deep Humanity - individual / collective gestalt

adjacency - between - Terrence Deacon explanation of symbolic language - symbolic language - no longer individual but parasitic on collective - Deep Humanity - individual / collective gestalt - adjacency relationship - Deacon asserts that the successful use of symbolic language implies we are no longer truly individual, that is - isolated, but rather are dependent on the collective - The Deep Humanity praxis recognizes the same intertwingledness in defining the individual/collective gestalt

for - question - no viable replacement for fossil fuels? - energy futures - deep geothermal

question - no viable replacement for fossil fuels? - That may not be true - Deep geothermal may be the viable answer in the short-to-medium term and - nuclear fusion may be the solution on the medium term - https://jonudell.info/h/facet/?max=100&expanded=true&user=stopresetgo&exactTagSearch=true&any=Deep+geothermal

for - adjacency - AI - Nora Bateson - solving wicked problems - no - Human Intelligence - HI - yes - @gyuri

for - key insight, adjacency - conformity bias - accepting evil - Russian citizen complacency - no protest

adjacency, key insight - between - geopolitics - Russia Ukraine War - complacency - oppression - adjacency relationship - Just like how ordinary German citizens accepted the death of millions of Jews, the same thing is happening in Russia. - Millions of ordinary Russian citizens are just doing what they can individually to survive day to day - If that means accepting the death of hundreds of thousands of innocents, then that is the price they will pay - Putin's oppression is so brutal that individuals risk their lives if they put up any resistance or protest

I imagine having to transmit stuff to every peer would not work well for low-bandwidth devices.

Also, complete connectivity graph is a LOT of connections.

Additionally, given one channel fails - recipient doesn't see content, while others do. (they could have broadcasted it, hey!)

Also, won't scale for streaming.

for - key insight - not knowing - advantages - quote - Rick Ruben - quote - advantages of having no references

quote - advantages of having no references - (see below)

• I had the advantage,
  • early in my career,
• of starting making music without any experience,
• which was helpful, because
  • I didn't know what rules I was breaking.
• And so it wasn't intentional breaking of rules.
  • I just did what seemed right to me,
  • but I didn't realize that I was doing things that other people wouldn't do.

How does this structure, without the quotations, deviate from other dialogue. What does it imply about these listing of hobbies, or listing of identity, and what is its effect on us, reading? How does this tie into Aciman's exploration of what identity really is? How does it connect to what WORDS mean?

Esto se usa para conocer todos los signos de caracteres que se pueden usar en una impresión. Los recuadros con una "X" por dentro, quiere decir que ese caracter corresponde a un fuente tipográfica que no está instalada aún.

Die Konzentration der drei wichtigsten Treibhausgase CO₂, Methan und NO₂ hat 2023 neue Rekordwerte erreicht. Die Daten der amerikanischen NOAA zeigen, dass sich der Anstieg im Durchschnitt der letzten Jahre nicht verlangsamt hat, auch wenn er in manchen Vorjahren noch steiler verlief. Die CO₂-Konzentation liegt 50% höher als in der vorindustriellen Zeit und entspricht der vor 4 Millionen Jahren. Die Atmosphäre enthält 160% mehr Methan als vor der Industrialisierung. Außer dem Verbrennen von Kohle, Öl und Gas ist die industrielle Landwirtschaft Hauptursache der Treibhausgas-Konzentration. https://www.theguardian.com/environment/2024/apr/06/record-highs-heat-trapping-gases-climate-crisis

Bericht: https://research.noaa.gov/2024/04/05/no-sign-of-greenhouse-gases-increases-slowing-in-2023/

Going back to the previous sentence, we see that the word tripe means either part of the stomach of an animal (mainly sheep and oxen) one eats or "rubbish" as used in slang, foreword that the men the author is describing, consistently indulging in said tripes (as shown in "licked his fingers" and "mischief") the men would have stunk physically from organs and trash and metaphorically, due to overindulgence and indecency.

definition of adultery and how it defers from poly

reasons people associate poly w/ unfaithful

because it evokes infidelity, people can have neg emotions towards poly

polyamory is associated with cheating

may link to the quote even though not supposed to be hierarchy

explicitly

In consensually non-monogamous relationships there is an open agreement that one, both, or all individuals involved in a romantic relationship may also have other sexual and/or romantic partners. R

suicide is the best solution, someone should tell her

Résumé de la vidéo [00:00:00][^1^][1] - [01:22:34][^2^][2]:

Cette vidéo est un webinaire organisé par Solidatech et Contournement, deux programmes de solidarité numérique qui aident les associations à renforcer leur impact grâce au numérique. Le webinaire présente les concepts et les outils du no code, c'est-à-dire la possibilité de créer des sites web, des applications, des outils internes et des automatisations sans avoir besoin de coder. Le webinaire explique les avantages du no code pour les associations, les différents types d'outils disponibles, les bonnes pratiques à adopter, et propose des démonstrations concrètes de création de projets no code.

Points clés: + [00:00:00][^3^][3] Présentation de Solidatech * Programme de solidarité numérique créé en 2008 * Facilite l'accès au numérique financièrement et accompagne aux usages * Propose des logiciels à tarif réduit, du matériel reconditionné, des ressources, des webinaires et des formations + [00:04:53][^4^][4] Présentation de Contournement * Programme de solidarité numérique créé en 2017 * Aide les associations à créer des sites, des applis et des automatisations sans coder * Propose des vidéos, des podcasts, des formations en ligne et des offres solidaires + [00:08:10][^5^][5] Introduction au no code * No code = créer des projets numériques visuellement sans écrire de code * Avantages : gain de temps, d'argent, d'autonomie, de créativité * Inconvénients : dépendance aux éditeurs, limites techniques, besoin de se former + [00:14:29][^6^][6] Panorama des outils no code * Différents types d'outils selon les besoins : site web, appli mobile, outil interne, automatisation, etc. * Différents niveaux d'accessibilité selon les compétences : débutant, confirmé, avancé * Exemples d'outils : Dorik, Webflow, Bubble, Glide, Zapier, Airtable, Notion, etc. + [00:20:10][^7^][7] Démonstration de Zapier * Zapier = outil no code qui permet d'interconnecter des outils entre eux pour automatiser des tâches * Exemple : automatiser le traitement des candidatures à une formation * Explication pas à pas de la création d'un zap (automatisation) + [00:29:00][^8^][8] Démonstration de Softr * Softr = outil no code qui permet de créer des sites web et des applis à partir de bases de données Airtable * Exemple : créer un site de recrutement pour les métiers du no code * Explication pas à pas de la création d'un site avec Softr + [00:36:38][^9^][9] Bonnes pratiques du no code * Commencer par définir son besoin et son objectif * Choisir l'outil le plus adapté à son projet * Se former et se documenter sur l'outil choisi * Tester et itérer son projet * Se faire accompagner par des experts si besoin + [00:39:34][^10^][10] Questions-Réponses * Réponses aux questions des participants sur le no code, les outils, la sécurité, le rgpd, etc. * Présentation d'un bon d'achat de 80 euros valable un mois sur les formations de Contournement * Conclusion et remerciements

Résumé de la vidéo [00:00:00][^1^][1] - [01:30:42][^2^][2] :

Cette vidéo est une présentation en français sur les outils numériques pour les associations, organisée par Solidatech et animée par Erwan Khezzar, cofondateur de Contournement. Elle aborde les sujets suivants :

Points forts : + [00:00:00][^3^][3] Présentation de Solidatech * Un programme de solidarité numérique créé en 2008 * Une filiale des Ateliers du Bocage, membre du mouvement Emmaüs * Plus de 32 000 associations bénéficiaires et plus de 500 000 outils numériques distribués + [00:04:12][^4^][4] Présentation de Contournement * Une entreprise qui forme à contourner les obstacles techniques du numérique * Une approche basée sur les outils no code, qui permettent de créer des sites, des applis, des outils sans écrire de code * Un exemple de projet réalisé avec Glide : H24 Urgence, une appli qui cartographie les maisons de santé + [00:15:32][^5^][5] Panorama des outils no code * Une typologie des outils selon leur fonctionnalité : création de sites, d'applis, d'outils, d'automatisation, etc. * Une présentation de plusieurs outils avec leurs avantages et leurs limites : Webflow, Bubble, Glide, Airtable, Zapier, Notion, etc. * Une démonstration de Airtable, un outil de gestion de bases de données visuelles et collaboratives + [01:11:22][^6^][6] Questions-réponses * Des réponses aux questions des participants sur les outils no code, leur utilisation, leur coût, leur sécurité, etc. * Des conseils et des ressources pour se former et se lancer dans le no code * Une offre de réduction pour la formation initiation au no code de Contournement

Reportage über die ZAD (Zone à défendre, zu verteidigenden Zone), mit der der Bau der Autobahn A69 von Toulouse nach Castres aufgehalten werden soll. An diesem Wochenende nahm auch Greta Thunberg an den Aktionen teil. Ein Zeltlager von Aktivist:innen ist nur auf Privatgrund erlaubt. Demonstrationen wurden verboten. Baumhäuser würden entlang der geplanten Strecke errichtet. Sehr viele Bäume wurden in den vergangenen Monaten bereits gefällt. https://www.liberation.fr/environnement/opposition-a-la69-dans-le-tarn-greta-thunberg-denonce-un-systeme-toxique-fonde-sur-lexploitation-20240210_V2HTRNV5CRFC7MF73LUQ7AAFLY/

Ausführlicher Artikel zum Hintergrund der Entscheidung der Biden-Adminstration, den Bau der LNG-Terminals CP2 nicht ohne Überprüfung der Klimawirkung zu genehmigen. Zur Zeit haben die USA sieben LNG-Export-Terminals, fünf sind in Bau. CP2 wäre das bisher größte; es ist eines von 17 Terminals im Planungsstadium. Die USA sind weltweit führend beim LNG-Export und bei der Öl- und Gasproduktion insgesamt. CP2 soll, bei Baukosten von 10 Milliarden Dollar, 20 Millionen Tonnen LNG im Jahr verschiffen, 20% der US- Exporte. https://www.nytimes.com/2024/01/24/climate/biden-lng-export-terminal-cp2.html

What does that mean exactly?

All of a sudden my Rails app's attempts to send via SMTP started getting rejected until I enabled "Less secure app access". It would be nice if I knew what was necessary to make the access considered "secure".

Update: Newer information added to this article (as well as elsewhere) leads me to believe that it is specifically sending password directly as authentication mechanism which was/is no longer permitted.

This is the note that has since been added on this page, which clarifies this point:

To help keep your account secure, from May 30, 2022, ​​Google no longer supports the use of third-party apps or devices which ask you to sign in to your Google Account using only your username and password.

• for: James Hansen - 2023 paper, key insight - James Hansen, leverage point - emergence of new 3rd political party, leverage point - youth in politics, climate change - politics, climate crisis - politics

• Key insight: James Hansen

  • The key insight James Hansen conveys is that
    • the key to rapid system change is
      • WHAT? the rapid emergence of a new, third political party that does not take money from special interest lobbys.
      • WHY? Hit the Achilles heel of the Fossil Fuel industry
      • HOW? widespread citizen / youth campaign to elect new youth leaders across the US and around the globe
      • WHEN? Timing is critical. In the US,
        • Don't spoil the vote for the two party system in 2024 elections. Better to have a democracy than a dictatorship.
        • Realistically, likely have to wait to be a contender in the 2028 election.

• reference

  • paper - Global Warming in the Pipeline
    • https://hyp.is/go?url=https%3A%2F%2Facademic.oup.com%2Foocc%2Farticle%2F3%2F1%2Fkgad008%2F7335889&group=world
  • Michael Mann's critique of the paper
    • https://hyp.is/go?url=https%3A%2F%2Fmichaelmann.net%2Fcontent%2Fcomments-new-article-james-hansen&group=world

good lord

• for: quote - there is no center, it's a fiction, quote - James Schneider - Progressive International

• quote

• key point
  • the things that the overwhelming majority of people support are not on the political agenda
    • which is why this whole the idea that there is a center in politics is a complete fiction
  • Elite consensus opinion is almost always massively in the minority
    • and so you have to work very hard to prevent things which are massively in the majority from getting political expression
  • Polling between 2/3 and 3/4 of people support (including generally speaking the majority of people who voted in the last election support) things like
    • public ownership of
      • energy
      • water
      • rail
      • mail, etc
    • a 15 pound an hour minimum wage
    • a wealth tax
• All of these things considered way way on the left are not on the left, that's actually the center if you're talking about where is the mainstream British public opinion - and it's such strong public opinion because no one ever says it in the public sphere and when they do they are ridiculed
• author: James Schneider, Progressive International
• date: Dec, 2023

• for: stats - oil and gas industry - steep drop in production

• stats - oil and gas industry - steep drop in production

  • no new fields can be developed to meet a 1.5 Deg C scenario
  • any new developments face the certain risk of being a stranded asset
  • by 2040, 7 million less barrels of oil are produced each day to meet a 1.5 Deg C scenario

Kojin Karatani (1941- )

Wikipedia (en)

https://en.wikipedia.org/wiki/Kojin_Karatani

accessed:: 2023-11-22 16:!0

Jun Tosaka (1900-1945)

Wikipedia (en)

https://en.wikipedia.org/wiki/Jun_Tosaka

accessed:: 2023-11-22 16:00

https://taz.de/Bericht-der-Weltwetterorganisation/!5969797&s=WMO/

• for: self awareness of no-self, adjacency - evolution - no-self - Fransisco Verella, quote - Fransisco Verella, quote - evolution - solidified self, question - awakening to no-self

• quote: Fransisco Verella

  • Evolution has designed you so that you just want to hurry on with your solidified self. They is what the sense of being a separate organism is about.

• date: 1999

• comment

  • Verella claims evolution has designed us to have no self awareness of no-self, the origins of the self.
  • even this phrase seems like an oxymoron 'self awareness of no-self!'
• question
  • how would a less complex, more primitive life form even have self awareness? What does that mean biologically? At that most rudimentary level, I suppose it would mean sensory feedback signals,
• question
  • Does this imply that (emotionally or affectively) awakening to your origins of self leads to second guessing ourselves as well? From observation of the behaviour of awakened individuals, this does not seem to be the case. Rather, authentically awakens individuals appear to be associated with much higher levels of wisdom and compassion, which would seem to confer evolutionary fitness

• for: evolution - forgetting our non-self nature, adjacency - evolution - non-self - Fransisco Verella, adjacency - evolution - no-self - Fransisco Verella

• adjacency between

  • evolution
  • non-self
  • Francisco Verella
• adjacency statement
  • Verella makes the interesting claim that evolution designer is to be blind to our lack of self
  • in fact, major evolutionary transitions in individuality embed the creation of a new higher order individual at each major stage of transition.
  • More fundamentally, major evolutionary transitions to individuals at each level need to define a biological self through a new physiological boundary between what constitutes a new unitary individual "self" (our inner world) and the rest of the environment ( our new outer world)
  • It will be interesting to see how Verella's claim reconcile with that

• for: quote - Fransisco Verella, quote - evolution - no-self

• quote: Fransisco Verella

  • In some sense, a heightened degree of self-awareness is anti evolutionary
• date: 1999

Environmental Impact of WW1 by NHC Education Programs https://www.youtube.com/watch?v=lucJElPVYOk

That [Ireland] is No Country for Old Men