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  1. Jan 2019
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mu-opioid receptor up-regulation and functional supersensitivity are independent of antagonist efficacy. - PubMed - NCBI
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    1. Drugs_and_Ethics 16 Jan 2019
      inverse agonist activity was not required for mu-opioid receptor up-regulation and supersensitivity.

      The question, then, is whether the opioid receptors are involved at all in this upregulation. For example, it could be mediated by TLR4 or filamin A.

      naltrexone naloxone reverse tolerance
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    ncbi.nlm.nih.gov/pubmed/17698975