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  1. Jan 2019
  2. pubs.acs.org pubs.acs.org
    Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2
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    1. Drugs_and_Ethics 05 Jan 2019
      Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2

      I've found elsewhere that mu agonism combined with delta antagonism provides analgesia while minimizing tolerance.

      kratom tolerance
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    pubs.acs.org/doi/abs/10.1021/acs.jmedchem.6b00748