2 Matching Annotations
  1. May 2019
  2. elifesciences.org elifesciences.org
    CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16
    2
    1. itextmine 12 May 2019
      However, unlike insulin signaling, UNC-43 phosphorylates and activates DAF-16, thus promoting its nuclear localization. The phosphorylation of DAF-16 at S286 by UNC-43 is removed by TAX-6•CNB-1, leading to DAF-16 inactivation.

      Kinase: UNC-43 (O62305) <br /> Substrate: DAF-16 (O16850) <br /> Site: Ser-286

      udel: RLIMS-P UniProt:O62305 UniProt:O16850
    2. itextmine 12 May 2019
      DAF-16 is phosphorylated by the AKT kinases, preventing its nuclear translocation.

      Kinase: AKT kinases <br /> Substrate: DAF-16 (O16850) <br />

      udel: RLIMS-P UniProt:O16850
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    elifesciences.org/articles/00518