3 Matching Annotations
- Jul 2022
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www.nejm.org www.nejm.org
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Central germline testing confirmed that 388 of the 391 patients had a BRCA1/2 mutation, 1 had a BRCA variant of uncertain significance, and 2 had wild-type BRCA. Testing at Foundation Medicine showed that the 2 patients with wild-type BRCA on central germline testing had somatic BRCA mutations
BRCA testing
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The use of maintenance therapy with olaparib provided a substantial benefit with regard to progression-free survival among women with newly diagnosed advanced ovarian cancer and a BRCA1/2 mutation, with a 70% lower risk of disease progression or death with olaparib than with placebo.
drug, clinical significance, disease, variant
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- May 2015
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shakespeare.mit.edu shakespeare.mit.edu
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You shall be king.
You shall be king. at 7274..7292
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