Eleven patients with sporadic hemangioblastomas were enrolled and diagnosed with a neurological examination. Four of these were found to have a germline mutation of the VHL gene. None of these patients had a definite family history of VHL disease or hemangioblastoma brain tumors. They had negative ophthalmoscopic examinations for hemangioblastoma, and unremarkable abdominal ultrasounds and computed tomographic imaging. Patient H13 (male, 58Y) presented with a spinal hemangioblastoma at C2. This patient underwent total excision of the tumor resulting in complete recovery. He was found to have the codon 133 (ACT to AACT) germline mutation of the VHL gene found through MLPA and PCR testing.