2 Matching Annotations
  1. May 2021
  2. Mar 2021
    1. NETs are also associated with thrombotic events in COVID-19, consisting of platelets, complement (C3) and tissue factor in blood

      Monocyte and neutrophil aggregates with platelets have been identified in COVID-19 patients and correlate with disease severity https://doi.org/10.1055/s-0040-1718732

      Von Willebrand’s factor and ADAMTS13 are also implicated in NET-associated immunothrombosis https://doi.org/10.3389/fimmu.2020.610696 , https://doi.org/10.1002/ctm2.268

      Additionally, NETs have been shown to accumulate and persist in the lungs of severe COVID-19 patients https://doi.org/10.1093/infdis/jiab053 and recruits coagulation Factor XII to promote clotting https://doi.org/10.1101/2020.12.29.424644 .

      This persistence is attributed to poor DNase clearance of NETs https://doi.org/10.1111/all.14746