- Aug 2022
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www.thelancet.com www.thelancet.com
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Huang, L., & Cao, B. (2021). Post-acute conditions of patients with COVID-19 not requiring hospital admission. The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(21)00225-5
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- Mar 2021
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academic.oup.com academic.oup.com
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NETs are also associated with thrombotic events in COVID-19, consisting of platelets, complement (C3) and tissue factor in blood
Monocyte and neutrophil aggregates with platelets have been identified in COVID-19 patients and correlate with disease severity https://doi.org/10.1055/s-0040-1718732
Von Willebrand’s factor and ADAMTS13 are also implicated in NET-associated immunothrombosis https://doi.org/10.3389/fimmu.2020.610696 , https://doi.org/10.1002/ctm2.268
Additionally, NETs have been shown to accumulate and persist in the lungs of severe COVID-19 patients https://doi.org/10.1093/infdis/jiab053 and recruits coagulation Factor XII to promote clotting https://doi.org/10.1101/2020.12.29.424644 .
This persistence is attributed to poor DNase clearance of NETs https://doi.org/10.1111/all.14746
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