- Nov 2018
HGH response to clonidine was not correlated with plasma levels of noradrenaline, serum cortisol, free fatty acids, or blood glucose.
That's surprising, but it does not necessarily mean that the mechanism is not the lowering of FFAs. Clonidine does lower FFAs, but individual responses to FFA reduction may vary in magnitude.
In this test, endogenous depressives showed a significantly reduced HGH response to clonidine as compared to normal controls, neurotic-reactive depressives, and schizophrenics. However, no differences were found between the endogenous depressives and a group of schizoaffective patients.
It's possible that this is related to the hyper-vigilance observed in depressives.