Other normocytic anemias can be secondary to decreased life span of the cells that are produced
Normocytic anemias can be 1. Decrease in erythrocyte precursors in marrow (aplastic anaemia) 2. Decrease in erythrocyte lifespan (sickle cell anemia)
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- Mar 2026
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The macrocytic anemias reflect either abnormal nuclear maturation or a higher fraction of young, large red cells (reticulocytes).
Never knew of reticulocytes before reading this. Interesting how an excessive fraction of these will present as macrocytic aneamia.<br /> As stated in following sentence: macrocytic aneamia is termed megaloblastic when maturing erythrocytes have excessively large and young nuclei for the amount of hemoglobin in the cytoplasm (pernicious anaemia form deficiencies in B12 or folate and drugs that interfere with DNA synthesis cause this)
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Iron deficiency anemia resulting from chronic blood loss and the thalassemias are examples of microcytic anemia.
These make sense as microcytic anemias are resultant of low or abnormal hemoglobin production. e.g Thalassemias, most commonly a genetic disorder, is haemolysis due to abnormal or low heme in globin chains.
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Platelets are not cells but fragments of larger multinucleated cells in the marrow called megakaryocytes
Cellular or non cellular? Better to coin them thrombocytes.
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When blood hemoglobin levels fall (anemia), oxygen delivery to the kidneys falls, and the kidneys produce more erythropoietin, causing the marrow to produce more red cells. When hemoglobin levels rise, the kidneys produce less erythropoietin and the marrow fewer red cells.
renal EPO secretion is a negative feedback loop (I believe this is a correct statement?).
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In adults, most of the active marrow resides in the vertebrae, sternum, and ribs. In children, the marrow is more active in the long bones.
Did not know this. Had assumed most active more would always been in the long bones.
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