Searches will be conducted in CINAHL, CENTRAL, EMBASE, MEDLINE, Neuroscience Information Framework (NIF), PEDro, PsycINFO, PubMed, Scopus, and Web of Science databases.

The Neuroscience Information Framework (http://neuinfo.org/) lists over 2500 different databases with relevance for neuroscience.

The neuroscience community has also been instrumental in promoting the use of a standardized reporting system for research reagents, including and especially Abs, through the Neuroscience Information Framework (www.neuinfo.org), which serves as a prominent portal to the Antibody Registry (www.antibodyregistry.org), a database of over 2.4 million Abs, each of which has a unique identifier (e.g., ‘AB_1234567’), to ensure the unambiguous description of any particular Ab. This unique identifier is then built into the larger Research Resource Identification Initiative (www.scicrunch.org/resources) or RRID (Table 2) [51] such that each Antibody Registry unique identifier becomes a corresponding RRID identifier (e.g., ‘AB_1234567’ becomes ‘RRID: AB_1234567’).

Along with the data, we provide a data dictionary of terms. In the dictionary, standard descriptions for which ontologies exist are used. We searched the following sources for ontology: NeuroLEX (http://neurolex.org/wiki/Main_Page), a semantic wiki for terms used in neuroscience; the Neuroscience Information Framework (http://www.neuinfo.org/), a dynamic resource of web-based neuroscience data, materials, and tools (NeuroLEX terms are actually published in NIF); and NCI Metathesaurus http://ncimeta.nci.nih.gov/ncimbrowser/), a biomedical terminology database for translational and basic research. A detailed list of these terms is presented in Table 3, and examples include “socioeconomic status,” “SAPS” and “cognitive assessment.” For descriptions of without a standard ontology, such as “working memory” or “global rating of hallucinations,” we plan to work with NeuroLEX to arrive at standard definitions. The current version of the data dictionary can be downloaded through the data portal website, described below.

C57BL/6 male mice (27 total) from the National Institute on Aging representing three age groups (nice mice per comparative age group)—mature (5 months old), old (12 months old), and aged (24 months old)—using the Neuroscience Information Framework (NIF; http://neuinfo.org) [24]

The Neuroscience Information Framework (https://www.neuinfo.org) provides links into a very large amount of material on the web that relates to neuroscience. Its searching mechanism is sophisticated, and ontology based, making it a very effective start point.