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- Jul 2018
Our biophysical studies suggest that this upregulation might be due to a homeostatic regulatory mechanism (Figures 4A and 4B) (also see Turrigiano, 2008), which increases synaptic NMDAR to counterbalance the increase in blockage of NMDAR opening associated with chronic increase in [Mg2+]o.
Fascinating. A « calming » ion, Mg2+, triggers the generation of more receptors that are calmed by it, in an effort to restore the normal excitatory state.