5 Matching Annotations
  1. Aug 2019
    1. Magnesium reduces the intensity of addiction to opiates and psychostimulants (cocaine, amphetamine, nicotine, and others). It also decreases the auto-administration of cocaine and the relapse into cocaine and amphetamine intake, as well as reducing the experimental addiction to morphine, cocaine and other substances in animals. In heroin addicts, alcohol consumers and other drug abusers, the plasma and intracellular magnesium concentration is lower compared to healthy subjects.

      Precisely what I'd expect. However, I was hoping to find a placebo controlled trial. I'm nearly certain that magnesium show benefit. I'm less confident that such studies will use adequate doses of magnesium for the effects to reach statistical significance.

  2. Jul 2018
    1. This is possibly due to lower Mg2+ excretion rate in young animals

      This is fundamental. Mg excretion and aging.

    2. Our biophysical studies suggest that this upregulation might be due to a homeostatic regulatory mechanism (Figures 4A and 4B) (also see Turrigiano, 2008), which increases synaptic NMDAR to counterbalance the increase in blockage of NMDAR opening associated with chronic increase in [Mg2+]o.

      Fascinating. A « calming » ion, Mg2+, triggers the generation of more receptors that are calmed by it, in an effort to restore the normal excitatory state.

    1. Mg Citrate 0.26 ± 0.02 0.32 ± 0.03   0.33 ± 0.04*

      Interestingly, the superiority of magnesium citrate over other forms is most evident in salivary excretion, both acute and chronic. In particular, I had been led to believe that amino acid chelate was superior. Given that these results are consistent superior plasma levels, I take this to be reasonable evidence that the citrate form is superior for a given value of elemental magnesium. In this case, 300mg elemental Mg.

  3. Oct 2015
    1. Hostility also has been found to be the part of type A behavior that seems to have the most pernicious health effects, such as a heightened risk of cardiovascular disease. Forsaking a grudge may also free a person from hostility and all its unhealthy consequences. It probably isn’t just hostility and stress that link unforgiveness and poor health. According to a review of the literature on forgiveness and health that my colleague Michael Scherer and I published, unforgiveness might compromise the immune system at many levels. For instance, our review suggests that unforgiveness might throw off the production of important hormones and even disrupt the way our cells fight off infections, bacteria, and other physical insults, such as mild periodontal disease.

      Type A should take magnesium.