[Paper-level Aggregated] PMCID: PMC6549573

Evidence Type(s): Oncogenic

Summary: Mutation: G12D | Summary: The KRAS G12D mutation contributes to tumor development and progression in non-small-cell lung cancer (NSCLC) models and is associated with lung adenocarcinoma, particularly in patients with stage IV disease. It is implicated in the development of lung cancers and supports its classification as an oncogenic variant.

Gene→Variant (gene-first): KRAS(3845):G12D

Genes: KRAS(3845)

Variants: G12D

[Paper-level Aggregated] PMCID: PMC6549573

Evidence Type(s): Prognostic

Summary: Mutation: G12D | Summary: The KRAS G12D mutation is associated with prolonged survival in models with p53 deficiency, indicating a correlation with disease outcome independent of therapy.

Gene→Variant (gene-first): KRAS(3845):G12D

Genes: KRAS(3845)

Variants: G12D

[Paper-level Aggregated] PMCID: PMC6549573

Evidence Type(s): Predictive

Summary: Mutation: G12D | Summary: The KRAS G12D mutation is associated with response to bortezomib therapy in non-small-cell lung cancer (NSCLC), although it is noted that this mutation alone is not a robust predictor of response. It may correlate with treatment outcomes, but it was also associated with a lack of response in the majority of patients, indicating its potential predictive value regarding therapy response.

Gene→Variant (gene-first): KRAS(3845):G12D

Genes: KRAS(3845)

Variants: G12D

[Paragraph-level] PMCID: PMC6549573 Section: RESULTS PassageIndex: 12

Evidence Type(s): Oncogenic

Summary: Evidence Type: Oncogenic | Mutation: G12D | Summary: The KRAS G12D mutation is identified as contributing to tumor development or progression, particularly in the context of patients with KRAS G12D-mutant disease.

Gene→Variant (gene-first): 3845:G12D

Genes: 3845

Variants: G12D

[Paragraph-level] PMCID: PMC6549573 Section: RESULTS PassageIndex: 11

Evidence Type(s): Prognostic, Oncogenic

Summary: Evidence Type: Prognostic | Mutation: G12D | Summary: The KRAS G12D mutation is associated with prolonged survival in models with p53 deficiency, indicating a correlation with disease outcome independent of therapy. Evidence Type: Oncogenic | Mutation: G12D | Summary: The KRAS G12D mutation contributes to tumor development or progression, as evidenced by its presence in tumor models.

Gene→Variant (gene-first): 3845:G12D

Genes: 3845

Variants: G12D

[Paragraph-level] PMCID: PMC6549573 Section: RESULTS PassageIndex: 8

Evidence Type(s): Predictive, Oncogenic

Summary: Evidence Type: Predictive | Mutation: G12D | Summary: The KRAS G12D mutation was associated with a lack of response to bortezomib in the majority of patients, indicating its potential predictive value regarding therapy response. Evidence Type: Oncogenic | Mutation: G12D | Summary: The KRAS G12D mutation is implicated in the development and progression of lung adenocarcinoma, supporting its classification as an oncogenic variant.

Gene→Variant (gene-first): 3845:G12D

Genes: 3845

Variants: G12D

[Paragraph-level] PMCID: PMC6549573 Section: RESULTS PassageIndex: 4

Evidence Type(s): Predictive, Oncogenic

Summary: Evidence Type: Predictive | Mutation: G12D | Summary: The KRAS G12D mutation is associated with response evaluation to bortezomib therapy in lung cancer patients, indicating its potential predictive value for treatment response. Evidence Type: Oncogenic | Mutation: G12D | Summary: The KRAS G12D mutation is implicated in the development of lung cancers, supporting its classification as an oncogenic variant.

Gene→Variant (gene-first): 3845:G12D

Genes: 3845

Variants: G12D

[Paragraph-level] PMCID: PMC6549573 Section: RESULTS PassageIndex: 3

Evidence Type(s): Oncogenic, Predictive

Summary: Evidence Type: Oncogenic | Mutation: G12D | Summary: The KRAS G12D mutation is associated with lung adenocarcinoma and contributes to tumor development in patients with stage IV disease. Evidence Type: Predictive | Mutation: G12D | Summary: The presence of the KRAS G12D mutation in patients with lung cancer may correlate with response to treatment with bortezomib, indicating its predictive value for therapy outcomes.

Gene→Variant (gene-first): 3845:G12D

Genes: 3845

Variants: G12D

[Paragraph-level] PMCID: PMC6549573 Section: ABSTRACT PassageIndex: 1

Evidence Type(s): Predictive, Oncogenic

Summary: Evidence Type: Predictive | Mutation: G12D | Summary: The KRAS G12D mutation is associated with response to bortezomib therapy in non-small-cell lung cancer (NSCLC), although it is noted that this mutation alone is not a robust predictor of response. Evidence Type: Oncogenic | Mutation: G12D | Summary: The KRAS G12D mutation contributes to tumor development and progression in non-small-cell lung cancer (NSCLC) models.

Gene→Variant (gene-first): 3845:G12D

Genes: 3845

Variants: G12D

[Paper-level Aggregated] PMCID: PMC6549573

Evidence Type(s): Oncogenic, Predictive, Prognostic

Justification: Oncogenic: The KRAS G12D mutation is described as a characteristic of the lung adenocarcinomas being studied, indicating its role in the oncogenesis of these tumors. Predictive: The text mentions that KRAS G12D mutation alone is not a robust predictor of response to bortezomib, suggesting its potential role in predicting treatment outcomes, albeit not reliably. Prognostic: The overall survival and progression-free survival data provided in the study suggest that the presence of the KRAS G12D mutation may have implications for the prognosis of patients with advanced NSCLC.

Gene→Variant (gene-first): KRAS(3845):G12D

Genes: KRAS(3845)

Variants: G12D

[Paragraph-level] PMCID: PMC6549573 Section: RESULTS PassageIndex: 12

Evidence Type(s): Oncogenic

Justification: Oncogenic: The presence of the KRAS G12D mutation is discussed in the context of tumor analysis, indicating its role in contributing to tumor development or progression, particularly as it is mentioned alongside other mutations in a patient with no observed responses.

Gene→Variant (gene-first): 3845:G12D

Genes: 3845

Variants: G12D

[Paragraph-level] PMCID: PMC6549573 Section: RESULTS PassageIndex: 11

Evidence Type(s): Oncogenic, Prognostic

Justification: Oncogenic: The passage discusses the KRAS G12D variant in the context of tumor regression and survival in specific mouse models, indicating its role in tumor development or progression. Prognostic: The mention of prolonged survival in the context of the KRAS G12D variant suggests a correlation with disease outcome, independent of therapy.

Gene→Variant (gene-first): 3845:G12D

Genes: 3845

Variants: G12D

[Paragraph-level] PMCID: PMC6549573 Section: RESULTS PassageIndex: 8

Evidence Type(s): Predictive, Diagnostic, Oncogenic

Justification: Predictive: The passage discusses the response to bortezomib in patients with KRAS G12D-mutant lung adenocarcinomas, indicating a correlation between the variant and treatment response. Diagnostic: The KRAS G12D mutation is identified through molecular profiling as part of the patient's diagnosis, linking the variant to the classification of the disease. Oncogenic: The KRAS G12D mutation is described in the context of tumor development and progression, as it is a known driver mutation in lung adenocarcinomas.

Gene→Variant (gene-first): 3845:G12D

Genes: 3845

Variants: G12D

[Paragraph-level] PMCID: PMC6549573 Section: RESULTS PassageIndex: 4

Evidence Type(s): Predictive, Diagnostic, Oncogenic

Justification: Predictive: The passage discusses the response of patients with KRAS G12D-mutant lung cancers to bortezomib, indicating a correlation between the variant and treatment response. Diagnostic: The mention of KRAS G12D in the context of lung cancers suggests its role in classifying or defining a specific subtype of the disease. Oncogenic: The variant KRAS G12D is implicated in lung cancers, indicating its contribution to tumor development or progression.

Gene→Variant (gene-first): 3845:G12D

Genes: 3845

Variants: G12D

[Paragraph-level] PMCID: PMC6549573 Section: RESULTS PassageIndex: 3

Evidence Type(s): Predictive, Diagnostic, Oncogenic

Justification: Predictive: The passage discusses patients with KRAS G12D-mutant lung cancers treated with bortezomib, indicating a correlation between the variant and response to therapy. Diagnostic: The mention of "KRAS G12D-mutant lung cancers" suggests that the variant is used to classify or define a specific subtype of lung cancer. Oncogenic: The variant KRAS G12D is implicated in the context of lung adenocarcinoma, indicating its role in tumor development or progression.

Gene→Variant (gene-first): 3845:G12D

Genes: 3845

Variants: G12D

[Paragraph-level] PMCID: PMC6549573 Section: ABSTRACT PassageIndex: 1

Evidence Type(s): Predictive, Oncogenic

Justification: Predictive: The passage discusses the correlation between the KRAS G12D mutation and response to the therapy bortezomib, indicating that exceptional responses can be achieved in patients with this mutation. Oncogenic: The KRAS G12D mutation is described as a somatic variant that contributes to tumor development in non-small-cell lung cancer (NSCLC) models, indicating its role in oncogenesis.

Gene→Variant (gene-first): 3845:G12D

Genes: 3845

Variants: G12D

[Paragraph-level] PMCID: PMC6549573 Section: ABSTRACT PassageIndex: 1

Evidence Type(s): Predictive, Oncogenic

Justification: Predictive: The passage discusses the correlation between the KRAS G12D mutation and response to the therapy bortezomib, indicating that exceptional responses can be achieved in patients with this mutation. Oncogenic: The KRAS G12D mutation is described as a somatic variant that contributes to tumor development in non-small-cell lung cancer (NSCLC) models, indicating its role in oncogenesis.

Gene→Variant (gene-first): 3845:G12D

Genes: 3845

Variants: G12D