On 2016 Aug 15, ALAN HOWE commented:

After 15 years, this remains one of my favorite papers. The simplicity of the methodology - pulsed growth factor treatment, followed by kinase assays or measurement of 3H-thymidine incorporation - is sublime and matched only by the solidity of the experimental design and the accuracy and understated power of the interpretation of the results. I re-read this article every few months and, in the midst of a constant drive towards 'innovation' and reliance on increasingly complex experimental approaches, it shines even brighter as an example of the power of that simple assays, perfectly executed and interpreted, have in scientific discovery.

On 2016 Aug 15, ALAN HOWE commented:

After 15 years, this remains one of my favorite papers. The simplicity of the methodology - pulsed growth factor treatment, followed by kinase assays or measurement of 3H-thymidine incorporation - is sublime and matched only by the solidity of the experimental design and the accuracy and understated power of the interpretation of the results. I re-read this article every few months and, in the midst of a constant drive towards 'innovation' and reliance on increasingly complex experimental approaches, it shines even brighter as an example of the power of that simple assays, perfectly executed and interpreted, have in scientific discovery.