- Jul 2018
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europepmc.org europepmc.org
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On 2016 Mar 12, Mark Milton commented:
This article contains the following statement "Recombinant proteins with a molecular weight of greater than 60 kd may be taken up by the reticuloendothelial system and catabolized by the liver." No reference was provided to substantiate this statement and is in conflict with "conventional wisdom" regarding the clearance of proteins, including therapeutic IgG antibodies. I would encourage readers not to cite this article when describing how therapeutic proteins and antibodies are cleared from the body.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
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europepmc.org europepmc.org
-
On 2016 Mar 12, Mark Milton commented:
This article contains the following statement "Recombinant proteins with a molecular weight of greater than 60 kd may be taken up by the reticuloendothelial system and catabolized by the liver." No reference was provided to substantiate this statement and is in conflict with "conventional wisdom" regarding the clearance of proteins, including therapeutic IgG antibodies. I would encourage readers not to cite this article when describing how therapeutic proteins and antibodies are cleared from the body.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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