On 2015 Jan 19, Paul Korir commented:

This paper claims that in about half (49%) of transcription units with multiple splice forms it appeared that usage of an alternative TSS was accompanied by alternative splicing of the initial exon. The authors therefore conclude that this might imply that alternative TSS may induce alternative splicing. However, if a transcription unit has a 50-50 chance of exhibiting this behaviour that would be the last conclusion that one could make. There are no positive epistemic implications that can be derived from a 50-50 chance; in fact, this is state with the maximal entropy and by extension the most uncertainty.

On 2015 Jan 19, Paul Korir commented:

This paper claims that in about half (49%) of transcription units with multiple splice forms it appeared that usage of an alternative TSS was accompanied by alternative splicing of the initial exon. The authors therefore conclude that this might imply that alternative TSS may induce alternative splicing. However, if a transcription unit has a 50-50 chance of exhibiting this behaviour that would be the last conclusion that one could make. There are no positive epistemic implications that can be derived from a 50-50 chance; in fact, this is state with the maximal entropy and by extension the most uncertainty.