- Jul 2018
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europepmc.org europepmc.org
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On 2016 Jul 29, Noel O'Boyle commented:
I believe that the description of the structure as cyclo-(D-NMePhe-L-Leu-L-Ile-L-NMeTyr-L-Phe-NMeGly-L-Pro) is incorrect, as the convention is to write the residues from the N terminus to the C terminus. This is a cyclic peptide, and thus missing the terminii, but there is still a directionality from the N of a residue towards its carbonyl.
In short, to be consistent with the X-ray and structural depiction, I believe that it should be written instead as cyclo-(L-Pro-NMeGly-L-Phe-L-NMeTyr-L-Ile-L-Leu-D-NMePhe).
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
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europepmc.org europepmc.org
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On 2016 Jul 29, Noel O'Boyle commented:
I believe that the description of the structure as cyclo-(D-NMePhe-L-Leu-L-Ile-L-NMeTyr-L-Phe-NMeGly-L-Pro) is incorrect, as the convention is to write the residues from the N terminus to the C terminus. This is a cyclic peptide, and thus missing the terminii, but there is still a directionality from the N of a residue towards its carbonyl.
In short, to be consistent with the X-ray and structural depiction, I believe that it should be written instead as cyclo-(L-Pro-NMeGly-L-Phe-L-NMeTyr-L-Ile-L-Leu-D-NMePhe).
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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