2 Matching Annotations
  1. Jul 2018
    1. On 2016 Jul 29, Noel O'Boyle commented:

      I believe that the description of the structure as cyclo-(D-NMePhe-L-Leu-L-Ile-L-NMeTyr-L-Phe-NMeGly-L-Pro) is incorrect, as the convention is to write the residues from the N terminus to the C terminus. This is a cyclic peptide, and thus missing the terminii, but there is still a directionality from the N of a residue towards its carbonyl.

      In short, to be consistent with the X-ray and structural depiction, I believe that it should be written instead as cyclo-(L-Pro-NMeGly-L-Phe-L-NMeTyr-L-Ile-L-Leu-D-NMePhe).


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  2. Feb 2018
    1. On 2016 Jul 29, Noel O'Boyle commented:

      I believe that the description of the structure as cyclo-(D-NMePhe-L-Leu-L-Ile-L-NMeTyr-L-Phe-NMeGly-L-Pro) is incorrect, as the convention is to write the residues from the N terminus to the C terminus. This is a cyclic peptide, and thus missing the terminii, but there is still a directionality from the N of a residue towards its carbonyl.

      In short, to be consistent with the X-ray and structural depiction, I believe that it should be written instead as cyclo-(L-Pro-NMeGly-L-Phe-L-NMeTyr-L-Ile-L-Leu-D-NMePhe).


      This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.