On 2013 Jul 03, Jessie Tenenbaum commented:

This is such a seminal paper in this area, and Connectivity Map data has proven very valuable in many follow-on studies by other authors- a great model for how data sharing can work.

I remember being struck by this sentence when I first read this paper- "There is no standard approach for estimating the statistical significance of the connections observed." I wonder if the authors would revise that 6 years later? Have they developed, or seen work by others, any methods to advance this capabilities? Certainly this flavor of analysis has been done many times. FDR seems to be the statistic of choice, though often applied somewhat differently on a case by case basis.

On 2013 Jul 03, Jessie Tenenbaum commented:

This is such a seminal paper in this area, and Connectivity Map data has proven very valuable in many follow-on studies by other authors- a great model for how data sharing can work.

I remember being struck by this sentence when I first read this paper- "There is no standard approach for estimating the statistical significance of the connections observed." I wonder if the authors would revise that 6 years later? Have they developed, or seen work by others, any methods to advance this capabilities? Certainly this flavor of analysis has been done many times. FDR seems to be the statistic of choice, though often applied somewhat differently on a case by case basis.