On 2015 Jan 31, Stephen Jacobs commented:

8 Years after this publication, the prevailing autoimmune explanation of celiac disease still has not been fleshed out. We have known for 10 years that gluten fragments activate T cells, but there remains no explanation of why that should cause a localized failure of gut function (often within half an hour), nor of why that should cause substantial remodeling of the epithelium. The blocked recognition hypothesis explains the nature and timing of the celiac response to gluten in some detail, and remains consistent with newer results.

On 2015 Jan 31, Stephen Jacobs commented:

8 Years after this publication, the prevailing autoimmune explanation of celiac disease still has not been fleshed out. We have known for 10 years that gluten fragments activate T cells, but there remains no explanation of why that should cause a localized failure of gut function (often within half an hour), nor of why that should cause substantial remodeling of the epithelium. The blocked recognition hypothesis explains the nature and timing of the celiac response to gluten in some detail, and remains consistent with newer results.