On 2016 Sep 07, Nalini M Rajamannan commented:

Thank you to open trials.net, we are grateful for your stringent checking of clinical trials.gov registration number. You are correct the exact registration number is NCT0014491.

The number 1 in the middle of the registration was missing in the final publication,

The typo was brought to our attention, and we did request for the final number 1 to be added to the publication, but the time to correct the typo was not possible due to the date of the original publication in 2007, according to the editorial office.

We agree that the discovery of the published NCT number: "The ID given is NCT0014491. We believe the correct ID, which we have found in the text in an embedded link, is NCT00114491."

On behalf of the RAAVE investigators, we are grateful for your diligent work and the correction of our registration in Clinicaltrials.gov as listed in PubMed Commons.

Sincerely

Nalini M. Rajamannan, MD

On 2016 Aug 30, Ben Goldacre commented:

This trial has the wrong trial registry ID associated with it on PubMed: both in the XML on PubMed, and in the originating journal article. The ID given is NCT0014491. We believe the correct ID, which we have found in the text in an embedded link, is NCT00114491.

This comment is being posted as part of the OpenTrials.net project^[1] , an open database threading together all publicly accessible documents and data on each trial, globally. In the course of creating the database, and matching documents and data sources about trials from different locations, we have identified various anomalies in datasets such as PubMed, and in published papers. Alongside documenting the prevalence of problems, we are also attempting to correct these errors and anomalies wherever possible, by feeding back to the originators. We have corrected this data in the OpenTrials.net database; we hope that this trial’s text and metadata can also be corrected at source, in PubMed and in the accompanying paper.

Many thanks,

Jessica Fleminger, Ben Goldacre*

[1] Goldacre, B., Gray, J., 2016. OpenTrials: towards a collaborative open database of all available information on all clinical trials. Trials 17. doi:10.1186/s13063-016-1290-8 PMID: 27056367

* Dr Ben Goldacre BA MA MSc MBBS MRCPsych<br> Senior Clinical Research Fellow<br> ben.goldacre@phc.ox.ac.uk<br> www.ebmDataLab.net<br> Centre for Evidence Based Medicine<br> Department of Primary Care Health Sciences<br> University of Oxford<br> Radcliffe Observatory Quarter<br> Woodstock Road<br> Oxford OX2 6GG

On 2016 Aug 30, Ben Goldacre commented:

This trial has the wrong trial registry ID associated with it on PubMed: both in the XML on PubMed, and in the originating journal article. The ID given is NCT0014491. We believe the correct ID, which we have found in the text in an embedded link, is NCT00114491.

This comment is being posted as part of the OpenTrials.net project^[1] , an open database threading together all publicly accessible documents and data on each trial, globally. In the course of creating the database, and matching documents and data sources about trials from different locations, we have identified various anomalies in datasets such as PubMed, and in published papers. Alongside documenting the prevalence of problems, we are also attempting to correct these errors and anomalies wherever possible, by feeding back to the originators. We have corrected this data in the OpenTrials.net database; we hope that this trial’s text and metadata can also be corrected at source, in PubMed and in the accompanying paper.

Many thanks,

Jessica Fleminger, Ben Goldacre*

[1] Goldacre, B., Gray, J., 2016. OpenTrials: towards a collaborative open database of all available information on all clinical trials. Trials 17. doi:10.1186/s13063-016-1290-8 PMID: 27056367

* Dr Ben Goldacre BA MA MSc MBBS MRCPsych<br> Senior Clinical Research Fellow<br> ben.goldacre@phc.ox.ac.uk<br> www.ebmDataLab.net<br> Centre for Evidence Based Medicine<br> Department of Primary Care Health Sciences<br> University of Oxford<br> Radcliffe Observatory Quarter<br> Woodstock Road<br> Oxford OX2 6GG

On 2016 Sep 07, Nalini M Rajamannan commented:

Thank you to open trials.net, we are grateful for your stringent checking of clinical trials.gov registration number. You are correct the exact registration number is NCT0014491.

The number 1 in the middle of the registration was missing in the final publication,

The typo was brought to our attention, and we did request for the final number 1 to be added to the publication, but the time to correct the typo was not possible due to the date of the original publication in 2007, according to the editorial office.

We agree that the discovery of the published NCT number: "The ID given is NCT0014491. We believe the correct ID, which we have found in the text in an embedded link, is NCT00114491."

On behalf of the RAAVE investigators, we are grateful for your diligent work and the correction of our registration in Clinicaltrials.gov as listed in PubMed Commons.

Sincerely

Nalini M. Rajamannan, MD