On 2017 Aug 20, Daniel Weiss commented:

This paper employs flawed circular reasoning.

The methods section clearly states that “in all patients with neurologic, cardiac or joint involvement, a serologic test positive for B. burgdorferi by ELISA and Western blot was required for case inclusion.”

Then in the results section, the authors state that “among the 44 patients with neurologic, heart or joint abnormalities, all had positive IgM or IgG responses to B. burgdorferi with 2 tier testing”… 2 tier testing had a sensitivity of 100%” .

This often cited manuscript claims that two tier testing has a sensitivity of 100% among those who have positive two tier tests. I urge all to read this paper before citing it.

On 2017 Aug 20, Daniel Weiss commented:

This paper employs flawed circular reasoning.

The methods section clearly states that “in all patients with neurologic, cardiac or joint involvement, a serologic test positive for B. burgdorferi by ELISA and Western blot was required for case inclusion.”

Then in the results section, the authors state that “among the 44 patients with neurologic, heart or joint abnormalities, all had positive IgM or IgG responses to B. burgdorferi with 2 tier testing”… 2 tier testing had a sensitivity of 100%” .

This often cited manuscript claims that two tier testing has a sensitivity of 100% among those who have positive two tier tests. I urge all to read this paper before citing it.