On 2014 May 15, Bill Sardi commented:

This abstract does not do justice to this landmark study. 12 weeks on an CR diet significantly differentiated 198 genes, resveratrol 225 genes,resveratrol+polyphenol (Longevinex) diet 1711 genes. Life-long CR diet in mice differentiates 831 genes. This suggests what takes a lifetime to accomplish epigenetically can be accomplished over a shorter time! Furthermore, the nutraceutical switched 677 of 831 (82%) longevity genes in the same direction (expressed or silenced) as CR, which makes this nutraceutical the closest molecular mimic of CR to date. (Note: I have a commercial interest in this nutraceutical)

On 2014 May 15, Bill Sardi commented:

This abstract does not do justice to this landmark study. 12 weeks on an CR diet significantly differentiated 198 genes, resveratrol 225 genes,resveratrol+polyphenol (Longevinex) diet 1711 genes. Life-long CR diet in mice differentiates 831 genes. This suggests what takes a lifetime to accomplish epigenetically can be accomplished over a shorter time! Furthermore, the nutraceutical switched 677 of 831 (82%) longevity genes in the same direction (expressed or silenced) as CR, which makes this nutraceutical the closest molecular mimic of CR to date. (Note: I have a commercial interest in this nutraceutical)