- Jul 2018
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europepmc.org europepmc.org
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On 2014 Aug 16, Christopher Southan commented:
A 2013 study of BACE evolution http://www.ncbi.nlm.nih.gov/pubmed/24381583 (the " A tale of two drug targets" citation link on the right) indicates the fly beta-secretase-like enzyme refered to above (UniProt Q9VLK3) is not in fact BACE-like but rather a lysosomal cathepsin. By the criteria detailed in that paper, true BACE-like homologs are absent from Drosophila and possibly all Ecdysozoa
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
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europepmc.org europepmc.org
-
On 2014 Aug 16, Christopher Southan commented:
A 2013 study of BACE evolution http://www.ncbi.nlm.nih.gov/pubmed/24381583 (the " A tale of two drug targets" citation link on the right) indicates the fly beta-secretase-like enzyme refered to above (UniProt Q9VLK3) is not in fact BACE-like but rather a lysosomal cathepsin. By the criteria detailed in that paper, true BACE-like homologs are absent from Drosophila and possibly all Ecdysozoa
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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