On 2015 Oct 07, Peter Good commented:

Shaw recently presented compelling evidence that acetaminophen (Tylenol) depletes glutathione in autism, asthma, and other disorders: “The characteristic loss of Purkinje cells in the brains of people with autism is consistent with depletion of brain glutathione due to excess acetaminophen usage, which leads to premature brain Purkinje cell death.”[1] Shaw observed that Cuba vaccinates all their children, especially against measles, yet their autism incidence is only 1/300th of ours in the U.S. What’s the difference, according to Shaw? Cuba prohibits over-the-counter acetaminophen, and only rarely allows acetaminophen prescribed for vaccinations, because acetaminophen is limited by the embargo. Deth noted that acetaminophen (like mercury) readily binds selenium-containing proteins that underlie the glutathione system [2]. By depleting glutathione, acetaminophen may effectively deplete glutamine because glutamine enters cells more easily than glutamate, thus often provides glutamate to synthesize glutathione [3].

As Shaw noted, Bauer and Kriebel reported recommendations that acetaminophen (paracetamol in the UK) be given before and after circumcision: “These guidelines include the suggestion of a first dose . . . two hours prior to the procedure, and doses every 4–6 hours for 24 hours following the procedure. Thus newborn males often receive 5–7 doses . . . during the developmentally vulnerable initial days of life.” They also cited evidence that may explain the increased number of children born autistic: “In the early 1980’s about 42% of women used paracetamol during the first trimester of pregnancy. The rate climbed to over 65% in the early 1990’s, where it has essentially remained through 2004.”[4]

For further evidence of glutathione depletion in autism, see: Chronic neurochemical asymmetry and dysconnection in autism. Implications of a personal trial of oral citrulline + taurine – published at <http:/www.autismstudies.net>

references 1. Shaw W. Evidence that increased acetaminophen use in genetically vulnerable children appears to be a major cause of the epidemics of autism, attention deficit with hyperactivity, and asthma. J Restorative Medicine 2013;2:1–16. 2. Deth R (PhD). Personal communication 2010. 3. Hong RW, Rounds JD, Helton SW, Robinson MK, Wilmore DW. Glutamine preserves liver glutathione after lethal hepatic injury. Ann Surg 1992;215:114–119. 4. Bauer AZ, Kriebel D. Prenatal and perinatal analgesic exposure and autism: an ecological link. Environ Health 2013;12:41.

On 2015 Oct 07, Peter Good commented:

Shaw recently presented compelling evidence that acetaminophen (Tylenol) depletes glutathione in autism, asthma, and other disorders: “The characteristic loss of Purkinje cells in the brains of people with autism is consistent with depletion of brain glutathione due to excess acetaminophen usage, which leads to premature brain Purkinje cell death.”[1] Shaw observed that Cuba vaccinates all their children, especially against measles, yet their autism incidence is only 1/300th of ours in the U.S. What’s the difference, according to Shaw? Cuba prohibits over-the-counter acetaminophen, and only rarely allows acetaminophen prescribed for vaccinations, because acetaminophen is limited by the embargo. Deth noted that acetaminophen (like mercury) readily binds selenium-containing proteins that underlie the glutathione system [2]. By depleting glutathione, acetaminophen may effectively deplete glutamine because glutamine enters cells more easily than glutamate, thus often provides glutamate to synthesize glutathione [3].

As Shaw noted, Bauer and Kriebel reported recommendations that acetaminophen (paracetamol in the UK) be given before and after circumcision: “These guidelines include the suggestion of a first dose . . . two hours prior to the procedure, and doses every 4–6 hours for 24 hours following the procedure. Thus newborn males often receive 5–7 doses . . . during the developmentally vulnerable initial days of life.” They also cited evidence that may explain the increased number of children born autistic: “In the early 1980’s about 42% of women used paracetamol during the first trimester of pregnancy. The rate climbed to over 65% in the early 1990’s, where it has essentially remained through 2004.”[4]

For further evidence of glutathione depletion in autism, see: Chronic neurochemical asymmetry and dysconnection in autism. Implications of a personal trial of oral citrulline + taurine – published at <http:/www.autismstudies.net>

references 1. Shaw W. Evidence that increased acetaminophen use in genetically vulnerable children appears to be a major cause of the epidemics of autism, attention deficit with hyperactivity, and asthma. J Restorative Medicine 2013;2:1–16. 2. Deth R (PhD). Personal communication 2010. 3. Hong RW, Rounds JD, Helton SW, Robinson MK, Wilmore DW. Glutamine preserves liver glutathione after lethal hepatic injury. Ann Surg 1992;215:114–119. 4. Bauer AZ, Kriebel D. Prenatal and perinatal analgesic exposure and autism: an ecological link. Environ Health 2013;12:41.