- Jul 2018
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europepmc.org europepmc.org
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On 2015 Jul 21, Richard Jenner commented:
Figure S3C of Davidovich C, 2015 shows that the apparent repressive effect of the Xist-RepA stem loop used as a control in Figure 6D of our paper Kanhere A, 2010 is actually due to a mutation of the construct promoter, which we had overlooked. As shown by Davidovich et al, correction of this mutation abolished the apparent repressive activity. Mutations were also found in the short RNA stem loop construct, however, although reduced, the repressive activity of this stem loop remained after these were corrected (Figure S3D of Davidovich C, 2015).
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
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europepmc.org europepmc.org
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On 2015 Jul 21, Richard Jenner commented:
Figure S3C of Davidovich C, 2015 shows that the apparent repressive effect of the Xist-RepA stem loop used as a control in Figure 6D of our paper Kanhere A, 2010 is actually due to a mutation of the construct promoter, which we had overlooked. As shown by Davidovich et al, correction of this mutation abolished the apparent repressive activity. Mutations were also found in the short RNA stem loop construct, however, although reduced, the repressive activity of this stem loop remained after these were corrected (Figure S3D of Davidovich C, 2015).
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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