On 2015 Aug 06, Serge R Mordon commented:

we thank Jan Tuner for having commented our article published 5 years ago. We confirm that we conducted a prospective comparative clinical trial aimed at evaluating 980 nm diode laser in laser-assisted venous ulcer healing. Laser parameters were chosen to generate a local temperature of 45-50 °C, which was controlled with a thermal infrared camera. Our study has nothing to do with LLLT. It would be very interesting to evaluate LLLT with the protocol used in our study before stating that LLLT is more effective on venous ulcer.

On 2015 Jul 18, Jan Tunér commented:

This study used 90 J/cm2, a very high dose, and because it was achieved by using a 15 W, 980 nm laser for 3 sec per cm2 and increasing the skin temperature up to maximum 50 degrees, it is obvious that this is not LLLT as we know it, and of course it is not effective. Traditional doses for wound healing are around 4 J/cm2 and low power and long time is more effective than high power and short time, even when applying the same energy. Reference: Castano A P, Dai T, Yaroslavsky I, Cohen R, Apruzzese W A, Smotrich M H, Hamblin M R. Low-level laser therapy for zymosan-induced arthritis in rats: Importance of illumination time. Lasers Surg Med. 2007; 39 (6): 543-550.

On 2015 Jul 18, Jan Tunér commented:

This study used 90 J/cm2, a very high dose, and because it was achieved by using a 15 W, 980 nm laser for 3 sec per cm2 and increasing the skin temperature up to maximum 50 degrees, it is obvious that this is not LLLT as we know it, and of course it is not effective. Traditional doses for wound healing are around 4 J/cm2 and low power and long time is more effective than high power and short time, even when applying the same energy. Reference: Castano A P, Dai T, Yaroslavsky I, Cohen R, Apruzzese W A, Smotrich M H, Hamblin M R. Low-level laser therapy for zymosan-induced arthritis in rats: Importance of illumination time. Lasers Surg Med. 2007; 39 (6): 543-550.

On 2015 Aug 06, Serge R Mordon commented:

we thank Jan Tuner for having commented our article published 5 years ago. We confirm that we conducted a prospective comparative clinical trial aimed at evaluating 980 nm diode laser in laser-assisted venous ulcer healing. Laser parameters were chosen to generate a local temperature of 45-50 °C, which was controlled with a thermal infrared camera. Our study has nothing to do with LLLT. It would be very interesting to evaluate LLLT with the protocol used in our study before stating that LLLT is more effective on venous ulcer.