- Jul 2018
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europepmc.org europepmc.org
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On 2016 Feb 16, Gary Goldman commented:
The Moro et al study concluded that influenza vaccine was safe during pregnancy. This study motivated the March of Dimes, backed by 10 healthcare sponsors (including the CDC), to send a statement of safety associated with the influenza vaccine to all obstetricians prior to the 2009/2010 two-dose (pandemic and seasonal) influenza season, based on (1) the few collected VAERS case reports for the past 20 years through the 2008/2009 influenza season, and (2) failed to account for underreporting to the VAERS database. However, the study authors were aware of an unusually large spike in the number of fetal deaths reports for the 2009/2010 pandemic influenza season (which was not included in the publication).
A hypothesis for the large spike in the number of fetal deaths among pregnant women receiving the two-dose protocol and a capture-recapture estimate of the true incidence of fetal deaths is presented in the Goldman study published in Hum Exp Toxicol 2013 May;32(5):464-75. Goldman GS, 2013
Further, a toxicological study using a different methodology came to a similar conclusion as Goldman GS. This study can be found in the archives of Toxicological & Environmental Chemistry as follows: Brown IA, Austin DW. Toxicological & Environmental Chemistry 2012 Sept;94(8):1610-27. Maternal transfer of mercury to the developing embryo/fetus: is there a safe level? DOI:10.1080/02772248.2012.724574 http://www.tandfonline.com/doi/abs/10.1080/02772248.2012.724574 Abstract: Mercury (Hg) exposure is ubiquitous in modern society via vaccines, fish/crustacea, dental amalgam, food, water, and the atmosphere. This article examines Hg exposure in the context of primary exposure to pregnant women and secondary exposure experienced by their unborn babies. Babies in utero are particularly at risk of higher Hg exposure than adults (on a dose/weight basis through maternal Hg transfer via the placenta), and are more susceptible to adverse effects from mercury and its biologically active compounds. It is, therefore, critical that regulatory advisories around maximum safe Hg exposures account for pregnant women and secondary exposure that children in utero experience. This study focused on standardized embryonic and fetal Hg exposures via primary exposure to the pregnant mother of two common Hg sources (dietary fish and parenteral vaccines). Data demonstrated that Hg exposures, particularly during the first trimester of pregnancy, at well-established dose/weight ratios produced severe damage to humans including death. In light of research suggestive of a mercuric risk factor for childhood conditions such as tic disorders, cerebral palsy, and autism, it is essential that Hg advisories account for secondary prenatal human exposures.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
-
europepmc.org europepmc.org
-
On 2016 Feb 16, Gary Goldman commented:
The Moro et al study concluded that influenza vaccine was safe during pregnancy. This study motivated the March of Dimes, backed by 10 healthcare sponsors (including the CDC), to send a statement of safety associated with the influenza vaccine to all obstetricians prior to the 2009/2010 two-dose (pandemic and seasonal) influenza season, based on (1) the few collected VAERS case reports for the past 20 years through the 2008/2009 influenza season, and (2) failed to account for underreporting to the VAERS database. However, the study authors were aware of an unusually large spike in the number of fetal deaths reports for the 2009/2010 pandemic influenza season (which was not included in the publication).
A hypothesis for the large spike in the number of fetal deaths among pregnant women receiving the two-dose protocol and a capture-recapture estimate of the true incidence of fetal deaths is presented in the Goldman study published in Hum Exp Toxicol 2013 May;32(5):464-75. Goldman GS, 2013
Further, a toxicological study using a different methodology came to a similar conclusion as Goldman GS. This study can be found in the archives of Toxicological & Environmental Chemistry as follows: Brown IA, Austin DW. Toxicological & Environmental Chemistry 2012 Sept;94(8):1610-27. Maternal transfer of mercury to the developing embryo/fetus: is there a safe level? DOI:10.1080/02772248.2012.724574 http://www.tandfonline.com/doi/abs/10.1080/02772248.2012.724574 Abstract: Mercury (Hg) exposure is ubiquitous in modern society via vaccines, fish/crustacea, dental amalgam, food, water, and the atmosphere. This article examines Hg exposure in the context of primary exposure to pregnant women and secondary exposure experienced by their unborn babies. Babies in utero are particularly at risk of higher Hg exposure than adults (on a dose/weight basis through maternal Hg transfer via the placenta), and are more susceptible to adverse effects from mercury and its biologically active compounds. It is, therefore, critical that regulatory advisories around maximum safe Hg exposures account for pregnant women and secondary exposure that children in utero experience. This study focused on standardized embryonic and fetal Hg exposures via primary exposure to the pregnant mother of two common Hg sources (dietary fish and parenteral vaccines). Data demonstrated that Hg exposures, particularly during the first trimester of pregnancy, at well-established dose/weight ratios produced severe damage to humans including death. In light of research suggestive of a mercuric risk factor for childhood conditions such as tic disorders, cerebral palsy, and autism, it is essential that Hg advisories account for secondary prenatal human exposures.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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