On 2014 Feb 28, Valeria Fadda commented:

Valeria Fadda, Dario Maratea, Sabrina Trippoli, Roberta Gatto and Andrea Messori - HTA Unit, Regional Health System, 50100 Firenze (Italy)

Since the meta-analysis by Maratea and co-workers was carried out with relative risk (RR) as outcome measure, we recomputed these results according to the outcome measure of risk difference (RD) by using random-effect model. Figure 1 (available at http://www.osservatorioinnovazione.net/papers/thr_res2014.jpg), show the outcome measures (RD) calculated for individual trials (squares = outcome measure; horizontal bars = 95%CIs of the outcome measure) and for the pooled analysis (diamond in blue and vertical dotted line in red). I2 is a measure of heterogeneity. Statistical calculations were performed by the OMA software (Open Meta-Analyst version 4.16.12, Tufts University, U.S., url http://tuftscaes.org/open_meta/). The complete references for the 10 randomized trials can be found in the article Maratea D, Fadda V, Trippoli S, Messori A. Prevention of venous thromboembolism after major orthopedic surgery: indirect comparison of three new oral anticoagulants. J Thromb Haemost. 2011 Sep;9(9):1868-70.

Abbreviations: Ev, number of events; Trt, number of patients receiving treatment.

On 2014 Feb 28, Valeria Fadda commented:

Valeria Fadda, Dario Maratea, Sabrina Trippoli, Roberta Gatto and Andrea Messori - HTA Unit, Regional Health System, 50100 Firenze (Italy)

Since the meta-analysis by Maratea and co-workers was carried out with relative risk (RR) as outcome measure, we recomputed these results according to the outcome measure of risk difference (RD) by using random-effect model. Figure 1 (available at http://www.osservatorioinnovazione.net/papers/thr_res2014.jpg), show the outcome measures (RD) calculated for individual trials (squares = outcome measure; horizontal bars = 95%CIs of the outcome measure) and for the pooled analysis (diamond in blue and vertical dotted line in red). I2 is a measure of heterogeneity. Statistical calculations were performed by the OMA software (Open Meta-Analyst version 4.16.12, Tufts University, U.S., url http://tuftscaes.org/open_meta/). The complete references for the 10 randomized trials can be found in the article Maratea D, Fadda V, Trippoli S, Messori A. Prevention of venous thromboembolism after major orthopedic surgery: indirect comparison of three new oral anticoagulants. J Thromb Haemost. 2011 Sep;9(9):1868-70.

Abbreviations: Ev, number of events; Trt, number of patients receiving treatment.