On 2013 Sep 26, Pedro Beltrao commented:

In this paper the authors showed to what extent it is possible to predict growth phenotypes for different "individuals" (i.e. strains) of S. cerevisiae from their genome sequences.They used single knock-out fitness information under different conditions from the S. cerevisiae lab strain to interpret the consequences of likely deleterious mutations within open reading frames for the different strains. This study attacks the problem of genotype-to-phenotype predictions from a new angle as opposed to the GWAS field and marks a potentially interesting new research direction.

On 2013 Sep 26, Pedro Beltrao commented:

In this paper the authors showed to what extent it is possible to predict growth phenotypes for different "individuals" (i.e. strains) of S. cerevisiae from their genome sequences.They used single knock-out fitness information under different conditions from the S. cerevisiae lab strain to interpret the consequences of likely deleterious mutations within open reading frames for the different strains. This study attacks the problem of genotype-to-phenotype predictions from a new angle as opposed to the GWAS field and marks a potentially interesting new research direction.