On 2014 Nov 26, Matthew Katz commented:

This UK trial establishes a key role for bladder preserving chemoradiation in muscle-invasive bladder cancer. While some patients may still benefit from radical cystectomy, chemoradiotherapy offers a viable alternative with good functional outcomes.

Recent data suggest that in the U.S. both cystectomy and chemoradiation and underused and have equal cancer control --> Smith AB, 2014. There has been increasing interest in neoadjuvant chemotherapy before cystectomy, and more research is needed. This trial demonstrates again how chemoradiation can offer cancer patients organ-preserving options.

Still unclear is the ideal area for treatment. This trial treated bladder only while many of the US trials treated small pelvic fields to include lymph nodes. Future studies should better address how to optimally treat bladder cancer patients with chemoradiation.

On 2014 Nov 26, Matthew Katz commented:

This UK trial establishes a key role for bladder preserving chemoradiation in muscle-invasive bladder cancer. While some patients may still benefit from radical cystectomy, chemoradiotherapy offers a viable alternative with good functional outcomes.

Recent data suggest that in the U.S. both cystectomy and chemoradiation and underused and have equal cancer control --> Smith AB, 2014. There has been increasing interest in neoadjuvant chemotherapy before cystectomy, and more research is needed. This trial demonstrates again how chemoradiation can offer cancer patients organ-preserving options.

Still unclear is the ideal area for treatment. This trial treated bladder only while many of the US trials treated small pelvic fields to include lymph nodes. Future studies should better address how to optimally treat bladder cancer patients with chemoradiation.