On 2014 Feb 16, S Sundar commented:

Pattern of benign and premalignant lesions detected by screening flexible Sigmoidoscopy

The reduction in cancer incidence and cancer-specific mortality in PLCO trial is almost certainly due to detection and treatment of ‘selected’ premalignant lesions that would have progressed to cancer. (1, 2) It would be helpful if the PLCO team can provide information (type, size, anatomical site and mode of treatment) on these precursor lesions, which in turn, if validated, would could serve as surrogate markers for chemoprevention studies.(3).

References

1. Croswell JM, Ransohoff DF, Kramer BS. Principles of cancer screening: lessons from history and study design issues. Semin Oncol 2010;37:202–15.
2. Schoen RE, Pinsky PF, Weissfeld JL, et al. Colorectal-Cancer Incidence and Mortality with Screening Flexible Sigmoidoscopy. N Engl J Med [Internet] 2012;Available from: http://dx.doi.org/10.1056/NEJMoa1114635
3. Cooper K, Squires H, Carroll C, et al. Chemoprevention of colorectal cancer: systematic review and economic evaluation. Health Technol Assess 2010;14:1–206.

On 2014 Feb 16, S Sundar commented:

Pattern of benign and premalignant lesions detected by screening flexible Sigmoidoscopy

The reduction in cancer incidence and cancer-specific mortality in PLCO trial is almost certainly due to detection and treatment of ‘selected’ premalignant lesions that would have progressed to cancer. (1, 2) It would be helpful if the PLCO team can provide information (type, size, anatomical site and mode of treatment) on these precursor lesions, which in turn, if validated, would could serve as surrogate markers for chemoprevention studies.(3).

References

1. Croswell JM, Ransohoff DF, Kramer BS. Principles of cancer screening: lessons from history and study design issues. Semin Oncol 2010;37:202–15.
2. Schoen RE, Pinsky PF, Weissfeld JL, et al. Colorectal-Cancer Incidence and Mortality with Screening Flexible Sigmoidoscopy. N Engl J Med [Internet] 2012;Available from: http://dx.doi.org/10.1056/NEJMoa1114635
3. Cooper K, Squires H, Carroll C, et al. Chemoprevention of colorectal cancer: systematic review and economic evaluation. Health Technol Assess 2010;14:1–206.